PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24481039-0 2014 Nicotine exerts neuroprotective effects against beta-amyloid-induced neurotoxicity in SH-SY5Y cells through the Erk1/2-p38-JNK-dependent signaling pathway. Nicotine 0-8 mitogen-activated protein kinase 3 Homo sapiens 112-118 24793809-11 2014 The silencing of alpha5-nAChR significantly inhibited the nicotine-induced cell proliferation compared with the control group and attenuated the nicotine-induced upregulation of HIF-1alpha and VEGF, and these effects required the cooperation of the ERK1/2 and PI3K/Akt signaling pathways. Nicotine 145-153 mitogen-activated protein kinase 3 Homo sapiens 249-255 27907022-13 2016 Nicotine enhanced podocyte phosphorylation of ERK1/2, JNK, and p38, and their specific inhibitors attenuated nicotine-induced apoptosis. Nicotine 0-8 mitogen-activated protein kinase 3 Homo sapiens 46-52 27907022-13 2016 Nicotine enhanced podocyte phosphorylation of ERK1/2, JNK, and p38, and their specific inhibitors attenuated nicotine-induced apoptosis. Nicotine 109-117 mitogen-activated protein kinase 3 Homo sapiens 46-52 26530054-0 2016 Nicotine enhances invasion and metastasis of human colorectal cancer cells through the nicotinic acetylcholine receptor downstream p38 MAPK signaling pathway. Nicotine 0-8 mitogen-activated protein kinase 3 Homo sapiens 135-139 24481039-3 2014 The aim of the present study was to assess the neuroprotective effects of nicotine against toxicity induced by beta-amyloid (Abeta) in relation to cell apoptosis, and to elucidate the role of the activation of the Erk1/2-p38-JNK pathway and the modulation of anti-apoptotic proteins in the nicotine-induced neuroprotective effects. Nicotine 290-298 mitogen-activated protein kinase 3 Homo sapiens 214-220 24481039-9 2014 The phosphorylation of Erk1/2, p38 and JNK increased following treatment with nicotine in the SH-SY5Y cells, whereas caspase-3 activation was inhibited by treatment with nicotine prior to exposure to Abeta25-35. Nicotine 78-86 mitogen-activated protein kinase 3 Homo sapiens 23-29 24481039-9 2014 The phosphorylation of Erk1/2, p38 and JNK increased following treatment with nicotine in the SH-SY5Y cells, whereas caspase-3 activation was inhibited by treatment with nicotine prior to exposure to Abeta25-35. Nicotine 170-178 mitogen-activated protein kinase 3 Homo sapiens 23-29 24481039-10 2014 Of note, these effects of nicotine against Abeta25-35-induced damage were abolished by inhibitors of Erk1/2, p38 and JNK phosphorylation. Nicotine 26-34 mitogen-activated protein kinase 3 Homo sapiens 101-107 22952803-7 2012 Nicotine also promoted the phosphorylation of ERK1/2 but not JNK and p38 proteins, thereby induced the activation of ERK/MAPK signaling pathway. Nicotine 0-8 mitogen-activated protein kinase 3 Homo sapiens 46-52 21070506-1 2012 From studies in cultured cells and animal models, nicotine and alcohol are known to regulate extracellular signal-regulated kinase 1 and 2 (ERK1/2). Nicotine 50-58 mitogen-activated protein kinase 3 Homo sapiens 140-146 21070506-8 2012 Multiple regression analysis revealed a significant relation among the number of cigarettes smoked daily (R(2)=0.266, P=0.003), the Fagerstrom Test for Nicotine Dependence score (R(2)=0.149, P=0.032) and the mRNA expression of ERK1. Nicotine 152-160 mitogen-activated protein kinase 3 Homo sapiens 227-231 22520577-9 2012 Nicotine induced a statistically significant increase in the expression of PI3K and in P-Akt/Akt ratio as well as in the expression of PKC, ERK1/2, survivin, and P-Bcl2 (Ser70) in both cell lines. Nicotine 0-8 mitogen-activated protein kinase 3 Homo sapiens 140-146 23149874-9 2012 These demonstrate that nicotine has ability to induce CRP expression in macrophages through nAChR-ERK1/2/p38 MAPK-NF-kappaB signal pathway, which contributes to better understanding of the pro-inflammatory and pro-atherosclerotic effects of nicotine in cigarette smokers. Nicotine 23-31 mitogen-activated protein kinase 3 Homo sapiens 98-104 22952803-7 2012 Nicotine also promoted the phosphorylation of ERK1/2 but not JNK and p38 proteins, thereby induced the activation of ERK/MAPK signaling pathway. Nicotine 0-8 mitogen-activated protein kinase 3 Homo sapiens 121-125 21781517-4 2011 PKC inhibitor staurosporine (STS) and ERK1/2 inhibitor PD98059 were used to detect PKC or ERK1/2 function on the expression of PAI-1 in HUVECs induced by nicotine. Nicotine 154-162 mitogen-activated protein kinase 3 Homo sapiens 90-96 19358273-8 2009 Nicotine activated the phosphorylation of ERK1/2, but not p38 or c-Jun NH2-terminal MAP kinases. Nicotine 0-8 mitogen-activated protein kinase 3 Homo sapiens 42-48 21781517-10 2011 CONCLUSION: PKC-ERK1/2 signal pathway may play a partial role in the up-regulation of PAI-1 induced by nicotine in HUVECs. Nicotine 103-111 mitogen-activated protein kinase 3 Homo sapiens 16-22 22085699-10 2011 Subsequently, Src, Akt and ERK1/2 were phosphorylated at different time points following nicotine treatment. Nicotine 89-97 mitogen-activated protein kinase 3 Homo sapiens 27-33 20106947-0 2010 Long-term nicotine exposure-induced chemoresistance is mediated by activation of Stat3 and downregulation of ERK1/2 via nAChR and beta-adrenoceptors in human bladder cancer cells. Nicotine 10-18 mitogen-activated protein kinase 3 Homo sapiens 109-115 20106947-9 2010 Furthermore, nicotine mobilized Stat3 signaling, resulting in the loss of extracellular signal-regulated protein kinase 1/2 (ERK 1/2) activation and reduced chemosensitivity via nicotinic acetylcholine receptors and beta-adrenoceptors. Nicotine 13-21 mitogen-activated protein kinase 3 Homo sapiens 125-132 19903766-5 2009 Here, we found that nicotine induces Mcl-1 phosphorylation through activation of extracellular signal-regulated kinase 1/2 in association with increased chemoresistance of human lung cancer cells. Nicotine 20-28 mitogen-activated protein kinase 3 Homo sapiens 81-122 19358273-9 2009 Inhibition of ERK1/2 activation reduced the nicotine-induced OPN synthesis. Nicotine 44-52 mitogen-activated protein kinase 3 Homo sapiens 14-20 17459420-7 2007 Exposure of SCLC or PNECs to NNK or nicotine increased expression of the alpha7nAChR and caused influx of Ca(2+), activation of PKC, Raf-1, ERK1/2, and c-myc, resulting in the stimulation of cell proliferation. Nicotine 36-44 mitogen-activated protein kinase 3 Homo sapiens 140-146 18448488-0 2008 Rapid activation of Stat3 and ERK1/2 by nicotine modulates cell proliferation in human bladder cancer cells. Nicotine 40-48 mitogen-activated protein kinase 3 Homo sapiens 30-36 18448488-6 2008 We found that nicotine simultaneously activates Stat3 and extracellular signal regulated kinase 1/2 (ERK1/2) in T24 cells. Nicotine 14-22 mitogen-activated protein kinase 3 Homo sapiens 101-107 18448488-9 2008 We conclude that through nAChR and beta-adrenoceptors, nicotine activates ERK1/2 and Stat3 signaling pathways, leading to Cyclin D1 expression and cell proliferation. Nicotine 55-63 mitogen-activated protein kinase 3 Homo sapiens 74-80 17459420-12 2007 NNK and nicotine-induced hyperactivity of the alpha7nAChR/RAF/ERK1/2 pathway thus appears to play a crucial role in the development of SCLC in smokers and could be targeted for cancer prevention. Nicotine 8-16 mitogen-activated protein kinase 3 Homo sapiens 62-68 16257255-6 2006 Therefore, we concluded that: (i) nicotine obviously up-regulates VCAM-1 and E-selectin expression at 15 min in HUVECs, (ii) nicotine activates HUVECs triggered by the ERK1/2 and p38 phosphorylation with an involvement of intracellular calcium mobilization chiefly mediated by alpha7 nicotinic receptor, (iii) intracellular Ca2+ activates a sequential pathway from alpha7 nicotinic receptor to the phosphorylation of ERK1/2, p38. Nicotine 34-42 mitogen-activated protein kinase 3 Homo sapiens 168-174 17003101-4 2007 In this connection, the ERK1/2 inhibitor U0126 abrogated the upregulation of AP-1 and COX-2 as well as cell proliferation induced by nicotine. Nicotine 133-141 mitogen-activated protein kinase 3 Homo sapiens 24-30 17003101-6 2007 Inhibition of PKC by staurosporine attenuated nicotine-induced ERK1/2 phosphorylation and COX-2 expression. Nicotine 46-54 mitogen-activated protein kinase 3 Homo sapiens 63-69 17003101-7 2007 Furthermore, atenolol and ICI 118,551, a beta1- and beta2-adrenoceptor antagonist, respectively, reversed the stimulatory action of nicotine on the expression of PKC, ERK1/2 phosphorylation, and COX-2 together with cell proliferation. Nicotine 132-140 mitogen-activated protein kinase 3 Homo sapiens 167-173 17003101-8 2007 Collectively, these results suggest that nicotine stimulates gastric cancer cell growth through the activation of beta-adrenoceptors and the downstream PKC-betaI/ERK1/2/COX-2 pathway. Nicotine 41-49 mitogen-activated protein kinase 3 Homo sapiens 162-168 16644474-6 2006 Moreover, calcium chelator BAPTA, ERK1/2 inhibitor PD98059, p38 inhibitor SB203580 significantly reduced the production of nicotine-activated surface/soluble VCAM-1 and E-selectin and both of the remained levels were no longer regulated by estrogen. Nicotine 123-131 mitogen-activated protein kinase 3 Homo sapiens 34-40 16644474-7 2006 Our study here provides the information of decrease effect of mER-mediated estrogen through Ca2+ and ERK1/2, p38 MAPK signaling pathway on nicotine-stimulated expression of surface/soluble VCAM-1 and E-selectin in HUVECs. Nicotine 139-147 mitogen-activated protein kinase 3 Homo sapiens 101-107 16644474-7 2006 Our study here provides the information of decrease effect of mER-mediated estrogen through Ca2+ and ERK1/2, p38 MAPK signaling pathway on nicotine-stimulated expression of surface/soluble VCAM-1 and E-selectin in HUVECs. Nicotine 139-147 mitogen-activated protein kinase 3 Homo sapiens 113-117 16716121-5 2006 Membrane array analysis subsequently suggested that both extracellular signal-regulated kinase (ERK) 1/2 and c-Jun-NH(2)-terminal kinase (JNK) signalings but not p38 MAPK signaling were activated in response to nicotine. Nicotine 211-219 mitogen-activated protein kinase 3 Homo sapiens 57-104 16716121-6 2006 Pretreatment of HBECs with specific inhibitors against ERK 1/2 and JNK but not p38 could significantly inhibit nicotine-induced interleukin- 8 production. Nicotine 111-119 mitogen-activated protein kinase 3 Homo sapiens 55-62 16716121-7 2006 These results suggest that MAPK pathway may mediate the effect of nicotine through ERK 1/2 and JNK but not p38 in HBECs treated with nicotine. Nicotine 66-74 mitogen-activated protein kinase 3 Homo sapiens 83-90 16716121-7 2006 These results suggest that MAPK pathway may mediate the effect of nicotine through ERK 1/2 and JNK but not p38 in HBECs treated with nicotine. Nicotine 133-141 mitogen-activated protein kinase 3 Homo sapiens 83-90 16257255-6 2006 Therefore, we concluded that: (i) nicotine obviously up-regulates VCAM-1 and E-selectin expression at 15 min in HUVECs, (ii) nicotine activates HUVECs triggered by the ERK1/2 and p38 phosphorylation with an involvement of intracellular calcium mobilization chiefly mediated by alpha7 nicotinic receptor, (iii) intracellular Ca2+ activates a sequential pathway from alpha7 nicotinic receptor to the phosphorylation of ERK1/2, p38. Nicotine 34-42 mitogen-activated protein kinase 3 Homo sapiens 417-423 16257255-6 2006 Therefore, we concluded that: (i) nicotine obviously up-regulates VCAM-1 and E-selectin expression at 15 min in HUVECs, (ii) nicotine activates HUVECs triggered by the ERK1/2 and p38 phosphorylation with an involvement of intracellular calcium mobilization chiefly mediated by alpha7 nicotinic receptor, (iii) intracellular Ca2+ activates a sequential pathway from alpha7 nicotinic receptor to the phosphorylation of ERK1/2, p38. Nicotine 125-133 mitogen-activated protein kinase 3 Homo sapiens 168-174 16257255-6 2006 Therefore, we concluded that: (i) nicotine obviously up-regulates VCAM-1 and E-selectin expression at 15 min in HUVECs, (ii) nicotine activates HUVECs triggered by the ERK1/2 and p38 phosphorylation with an involvement of intracellular calcium mobilization chiefly mediated by alpha7 nicotinic receptor, (iii) intracellular Ca2+ activates a sequential pathway from alpha7 nicotinic receptor to the phosphorylation of ERK1/2, p38. Nicotine 125-133 mitogen-activated protein kinase 3 Homo sapiens 417-423 12421819-6 2003 Nicotine induces activation of PKC alpha and the MAPKs ERK1 and ERK2, which are physiological Bcl2 kinases. Nicotine 0-8 mitogen-activated protein kinase 3 Homo sapiens 55-59 17168719-6 2006 Moreover, it has been recently reported that nicotine in lung adenocarcinoma A549 cells, potently induces Bad phosphorylation at serine (S)112, S136 and S155 in a mechanism involving activation of MAPKs, ERK1/2, PI3K/AKT and PKA through the linking to alpha7-receptors [9]. Nicotine 45-53 mitogen-activated protein kinase 3 Homo sapiens 204-210 15813854-7 2005 In addition, nicotine treatment stimulated rapid phosphorylation of Erk1/2 and p-38 in endothelial cells. Nicotine 13-21 mitogen-activated protein kinase 3 Homo sapiens 68-74 15037618-4 2004 Here we report that nicotine potently induces Bad phosphorylation at Ser112, Ser136, and Ser155 in a mechanism involving activation of MAPKs ERK1/2, PI3K/AKT, and PKA in human lung cancer cells. Nicotine 20-28 mitogen-activated protein kinase 3 Homo sapiens 141-147 15037618-7 2004 The fact that beta-adrenergic receptor inhibitor (propranolol) blocks nicotine-induced activation of ERK1/2, AKT, PKA, Bad phosphorylation, and cell survival suggests that nicotine-induced Bad phosphorylation may occur through the upstream beta-adrenergic receptors. Nicotine 70-78 mitogen-activated protein kinase 3 Homo sapiens 101-107 15037618-7 2004 The fact that beta-adrenergic receptor inhibitor (propranolol) blocks nicotine-induced activation of ERK1/2, AKT, PKA, Bad phosphorylation, and cell survival suggests that nicotine-induced Bad phosphorylation may occur through the upstream beta-adrenergic receptors. Nicotine 172-180 mitogen-activated protein kinase 3 Homo sapiens 101-107 34890707-10 2022 In this study, we found that nicotine induces IL-8 expression via ROS/NF-kappaB and ROS/MAPK (Erk1/2, p38)/AP-1 axis in gastric cancer cells, thus stimulating endothelial cell proliferation and angiogenesis in the tumor microenvironment. Nicotine 29-37 mitogen-activated protein kinase 3 Homo sapiens 94-100 11905997-2 2002 In SH-SY5Y cells and hippocampal neurones, nicotine (100 microM) increased the activity of ERK1/2. Nicotine 43-51 mitogen-activated protein kinase 3 Homo sapiens 91-97 11905997-6 2002 In contrast, two structurally different inhibitors of PKA (KT 5720 and H-89) completely prevented the nicotine-dependent increase in ERK1/2 activity. Nicotine 102-110 mitogen-activated protein kinase 3 Homo sapiens 133-139 11905997-7 2002 Inhibition of the nicotine-evoked increase in ERK1/2 activity by H-89 was also observed in hippocampal cultures. Nicotine 18-26 mitogen-activated protein kinase 3 Homo sapiens 46-52 29486207-0 2018 nAChRs-ERK1/2-Egr-1 signaling participates in the developmental toxicity of nicotine by epigenetically down-regulating placental 11beta-HSD2. Nicotine 76-84 mitogen-activated protein kinase 3 Homo sapiens 7-13 35563563-6 2022 We discovered that reactive oxygen species (ROS) and MAPKs (p38 MAPK, Erk1/2) are involved in nicotine-induced MMP-9 expression. Nicotine 94-102 mitogen-activated protein kinase 3 Homo sapiens 70-76 33662786-0 2021 Nicotine-derived NNK induces the stemness enrichment of CRC cells through regulating the balance of DUSP4-ERK1/2 feedback loop. Nicotine 0-8 mitogen-activated protein kinase 3 Homo sapiens 106-112 33355840-8 2021 In addition, we showed that E-cigarettes vapor with and without nicotine induce MUC5AC expression via activation of MAPK (ERK 1/2 and p38) and NF-kappaB signaling pathways in human airway epithelial cells. Nicotine 64-72 mitogen-activated protein kinase 3 Homo sapiens 122-129 32361056-5 2020 Moreover, flow cytometry and immunoblotting experiments revealed that ITH12680 reversed nicotine-induced cisplatin resistance in NSCLC cells, as it prevented nicotine-induced reduction of Bax expression and inhibited nicotine-mediated activation of cell survival and proliferation kinases, Akt and ERK1/2. Nicotine 88-96 mitogen-activated protein kinase 3 Homo sapiens 298-304 32361056-5 2020 Moreover, flow cytometry and immunoblotting experiments revealed that ITH12680 reversed nicotine-induced cisplatin resistance in NSCLC cells, as it prevented nicotine-induced reduction of Bax expression and inhibited nicotine-mediated activation of cell survival and proliferation kinases, Akt and ERK1/2. Nicotine 158-166 mitogen-activated protein kinase 3 Homo sapiens 298-304 32361056-5 2020 Moreover, flow cytometry and immunoblotting experiments revealed that ITH12680 reversed nicotine-induced cisplatin resistance in NSCLC cells, as it prevented nicotine-induced reduction of Bax expression and inhibited nicotine-mediated activation of cell survival and proliferation kinases, Akt and ERK1/2. Nicotine 158-166 mitogen-activated protein kinase 3 Homo sapiens 298-304 29715455-10 2018 During Th17 differentiation conditions, nicotine reduced the levels of IL-17A and RORc, induced the phosphorylation of ERK1/2. Nicotine 40-48 mitogen-activated protein kinase 3 Homo sapiens 119-125 34006831-11 2021 Additionally, nicotine provoked SOCS3, degraded AdipoR1, and attenuated APN-activated ERK1/2 in the presence of high glucose and high lipid (HG/HL) in human umbilical vein endothelial cells (HUVECs). Nicotine 14-22 mitogen-activated protein kinase 3 Homo sapiens 86-92 29486207-7 2018 In human BeWo cells, nicotine decreased 11beta-HSD2 expression, increased nAChRalpha9 expression, and activated ERK1/2/Elk-1/Egr-1 signaling in the concentration (0.1-10 muM)-dependent manner. Nicotine 21-29 mitogen-activated protein kinase 3 Homo sapiens 112-118 29486207-8 2018 Antagonism of nAChRs, inhibition of ERK1/2 and Egr-1 knockdown by siRNA were able to block/abrogate the effects of nicotine on histone modification and expression of 11beta-HSD2. Nicotine 115-123 mitogen-activated protein kinase 3 Homo sapiens 36-42 29017931-4 2017 Our results showed that acute nicotine administered prior to extinction sessions downregulated the phosphorylated forms of ERK1/2 in the ventral hippocampus, but not dorsal hippocampus, and JNK1 in both dorsal and ventral hippocampus on the 3rd extinction day. Nicotine 30-38 mitogen-activated protein kinase 3 Homo sapiens 123-129 29017931-7 2017 Finally, acute nicotine injections immediately after extinction sessions upregulated the phosphorylated forms of ERK1/2 in the ventral hippocampus, but did not affect JNK1. Nicotine 15-23 mitogen-activated protein kinase 3 Homo sapiens 113-119 28890319-0 2017 Arctic Abeta40 blocks the nicotine-induced neuroprotective effect of CHRNA7 by inhibiting the ERK1/2 pathway in human neuroblastoma cells. Nicotine 26-34 mitogen-activated protein kinase 3 Homo sapiens 94-100 28890319-8 2017 Furthermore, Arctic Abeta40 blocked the neuroprotective effect of nicotine by inhibiting the ERK1/2 pathway downstream of CHRNA7. Nicotine 66-74 mitogen-activated protein kinase 3 Homo sapiens 93-99 28890319-9 2017 Moreover, we show that ERK1/2 activation mediates the neuroprotective effect of nicotine against oxidative stress. Nicotine 80-88 mitogen-activated protein kinase 3 Homo sapiens 23-29