PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25799226-3	2015	Here we show that nicotine, a major constituent of cigarette smoke, selectively activates AMP-activated protein kinase alpha2 (AMPKalpha2) in adipocytes, which in turn phosphorylates MAP kinase phosphatase-1 (MKP1) at serine 334, initiating its proteasome-dependent degradation.	Nicotine	18-26	dual specificity phosphatase 1	Homo sapiens	183-207	
25799226-4	2015	The nicotine-dependent reduction of MKP1 induces the aberrant activation of both p38 mitogen-activated protein kinase and c-Jun N-terminal kinase, leading to increased phosphorylation of insulin receptor substrate 1 (IRS1) at serine 307.	Nicotine	4-12	dual specificity phosphatase 1	Homo sapiens	36-40	
25799226-3	2015	Here we show that nicotine, a major constituent of cigarette smoke, selectively activates AMP-activated protein kinase alpha2 (AMPKalpha2) in adipocytes, which in turn phosphorylates MAP kinase phosphatase-1 (MKP1) at serine 334, initiating its proteasome-dependent degradation.	Nicotine	18-26	dual specificity phosphatase 1	Homo sapiens	209-213	
23192567-5	2013	NaHS blocked nicotine and LPS-induced activation of p38, ERK, MKP-1, PI3K, PKC, and PKC isoenzymes, and NF-kappaB.	Nicotine	13-21	dual specificity phosphatase 1	Homo sapiens	62-67	
23192567-6	2013	The effects of H(2)S on nicotine- and LPS-induced osteoblastic and osteoclastic differentiation were remarkably reversed by MKP-1 enzyme inhibitor (vanadate) and expression inhibitor (triptolide).	Nicotine	24-32	dual specificity phosphatase 1	Homo sapiens	124-129