PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29572389-5 2018 In the present study, we examined the involvement of Wnt/beta-catenin pathway in nicotine-mediated mesangial cell growth in high glucose milieu. Nicotine 81-89 catenin beta 1 Homo sapiens 57-69 31792475-12 2019 The relative expression levels of Wnt pathway proteins including beta-catenin, c-Myc, p-GSK3beta and Ror2 were significantly higher in nicotine group than those in the blank control group and alpha7nAChR inhibition group (P<0.05). Nicotine 135-143 catenin beta 1 Homo sapiens 65-77 29572389-0 2018 Nicotine enhances mesangial cell proliferation and fibronectin production in high glucose milieu via activation of Wnt/beta-catenin pathway. Nicotine 0-8 catenin beta 1 Homo sapiens 119-131 29572389-9 2018 Similarly, nicotine increased the expression of Wnts, beta-catenin, and fibronectin in normal glucose medium, but further increased mesangial cell expression of these proteins in high glucose milieu. Nicotine 11-19 catenin beta 1 Homo sapiens 54-66 29572389-10 2018 Pharmacological inhibition or genetic knockdown of beta-catenin activity or expression with specific inhibitor FH535 or siRNA significantly impaired the nicotine/glucose-stimulated cell proliferation and fibronectin production. Nicotine 153-161 catenin beta 1 Homo sapiens 51-63 29572389-11 2018 We conclude that nicotine may enhance renal mesangial cell proliferation and fibronectin production under high glucose milieus partly through activating Wnt/beta-catenin pathway. Nicotine 17-25 catenin beta 1 Homo sapiens 157-169 28521453-0 2017 Nicotine may promote tongue squamous cell carcinoma progression by activating the Wnt/beta-catenin and Wnt/PCP signaling pathways. Nicotine 0-8 catenin beta 1 Homo sapiens 86-98 28521453-4 2017 Nicotine stimulation can promote proliferation, migration, and invasion of TSCC cells in vitro, downregulate E-cadherin, and activate the Wnt/beta-catenin and Wnt/PCP pathways, which could be antagonized by the alpha7 nicotine acetylcholine receptor (alpha7 nAChR) inhibitor alpha-BTX. Nicotine 0-8 catenin beta 1 Homo sapiens 142-154 28521453-6 2017 Our results suggest nicotine may promote tongue squamous carcinoma cells progression by activating the Wnt/beta-catenin and Wnt/PCP signaling pathways and may play a significant role in the progression and metastasis of smoking-related TSCC. Nicotine 20-28 catenin beta 1 Homo sapiens 107-119 26472220-0 2016 Nicotine reduces the levels of surfactant proteins A and D via Wnt/beta-catenin and PKC signaling in human airway epithelial cells. Nicotine 0-8 catenin beta 1 Homo sapiens 67-79 27118643-3 2016 METHODS: Real-time PCR and Western blot were used to detect the expression changes of EMT-related markers, E-cadherin and Vimentin, in A549 lung cancer cells treated with nicotine; The transposition of beta-catenin protein expression was determined by immunofluorescence; Scratch test and Transwell invasion assay were used to detect the effects of nicotine on lung cancer cell migration and invasion. Nicotine 171-179 catenin beta 1 Homo sapiens 202-214 27118643-3 2016 METHODS: Real-time PCR and Western blot were used to detect the expression changes of EMT-related markers, E-cadherin and Vimentin, in A549 lung cancer cells treated with nicotine; The transposition of beta-catenin protein expression was determined by immunofluorescence; Scratch test and Transwell invasion assay were used to detect the effects of nicotine on lung cancer cell migration and invasion. Nicotine 349-357 catenin beta 1 Homo sapiens 202-214 26472220-2 2016 We recently showed that in vitro nicotine exposure induces Wnt3a/beta-catenin activation, which is a pathway that has also been implicated in altering levels of SP-A and SP-D. Nicotine 33-41 catenin beta 1 Homo sapiens 65-77 26472220-5 2016 We showed that nicotine activated the Wnt3a/beta-catenin and PKC signaling pathway, and this activation was accompanied by a decrease in SP-A and SP-D expression. Nicotine 15-23 catenin beta 1 Homo sapiens 44-56 26001208-0 2016 Nicotine contributes to the neural stem cells fate against toxicity of microglial-derived factors induced by Abeta via the Wnt/beta-catenin pathway. Nicotine 0-8 catenin beta 1 Homo sapiens 127-139 26001208-7 2016 However, addition of 10 mumol/L nicotine before microglias treated with Abeta was beneficial to protect the NSCs against neurotoxicity of microglial-derived factors induced by Abeta, which partially rescued proliferation, differentiation and inhibited apoptosis of NSCs via activation of Wnt/beta-catenin pathway. Nicotine 32-40 catenin beta 1 Homo sapiens 292-304 23204070-2 2013 Studies have shown that cigarette smoke and nicotine are factors that induce Wnt/beta-catenin activation, which is a pathway that has also been implicated in EMT. Nicotine 44-52 catenin beta 1 Homo sapiens 81-93 25393899-10 2015 Furthermore, pretreatment with isoproterenol or resistin-specific siRNA blocked nicotine plus LPS-induced activation of phosphoinositide-3-kinase, glycogen synthase kinase-3 beta, beta-catenin, p38, ERK, JNK and nuclear factor-kappaB. Nicotine 80-88 catenin beta 1 Homo sapiens 180-192 24376645-10 2013 Activation of alpha7 nAChR by nicotine treatment activated wnt/beta-catenin signaling pathway, leading to osteogenic deficiency of hPDLSCs. Nicotine 30-38 catenin beta 1 Homo sapiens 63-75 23204070-0 2013 Nicotine-induced epithelial-mesenchymal transition via Wnt/beta-catenin signaling in human airway epithelial cells. Nicotine 0-8 catenin beta 1 Homo sapiens 59-71 23204070-3 2013 The main aim of this study was to test whether human bronchial epithelial cells are able to undergo EMT in vitro following nicotine stimulation via the Wnt3a/beta-catenin signaling pathway. Nicotine 123-131 catenin beta 1 Homo sapiens 158-170 23204070-4 2013 We show that nicotine activates the Wnt3a signal pathway, which leads to the translocation of beta-catenin into the nucleus and activation of beta-catenin/Tcf-dependent transcription in the human bronchial epithelial cell (HBEC) line. Nicotine 13-21 catenin beta 1 Homo sapiens 94-106 23204070-4 2013 We show that nicotine activates the Wnt3a signal pathway, which leads to the translocation of beta-catenin into the nucleus and activation of beta-catenin/Tcf-dependent transcription in the human bronchial epithelial cell (HBEC) line. Nicotine 13-21 catenin beta 1 Homo sapiens 142-154 23204070-9 2013 These results suggest that HBECs are able to undergo EMT in vitro upon nicotine stimulation via the Wnt3a/beta-catenin signaling pathway. Nicotine 71-79 catenin beta 1 Homo sapiens 106-118