PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31209145-9 2019 Pretreatment with nicotine reversed LPS-induced high levels of placental inflammatory cytokines, low levels of placental VEGF and placental pathological damage, then rescued the number and weights of live fetuses. Nicotine 18-26 vascular endothelial growth factor A Rattus norvegicus 121-125 31578682-12 2019 According to our findings, it can be suggested that nicotine has negative effects on microvascular circulation by increasing VEGF and MMP2 levels. Nicotine 52-60 vascular endothelial growth factor A Rattus norvegicus 125-129 31582019-0 2019 Nicotine-induced oxidative stress alters sciatic nerve barriers in rat through modulation of ZO-1 & VEGF expression. Nicotine 0-8 vascular endothelial growth factor A Rattus norvegicus 104-108 31582019-12 2019 A dose-dependent nicotine-induced oxidative stress on the sciatic nerve occurred via disruption of nerve barriers, altered VEGF and ZO-1 levels. Nicotine 17-25 vascular endothelial growth factor A Rattus norvegicus 123-127 31578682-0 2019 Nicotine increased VEGF and MMP2 levels in the rat eye and kidney. Nicotine 0-8 vascular endothelial growth factor A Rattus norvegicus 19-23 31578682-4 2019 The aim of this study was to investigate the effect of nicotine on VEGF and MMP2 levels in kidney and eyes, where microcirculation is very important for their function. Nicotine 55-63 vascular endothelial growth factor A Rattus norvegicus 67-71 31578682-7 2019 The VEGF and MMP2 levels were increased in kidney tissue of both genders as a result of given nicotine. Nicotine 94-102 vascular endothelial growth factor A Rattus norvegicus 4-8 31578682-9 2019 However, VEGF levels increased in the eye tissue with nicotine in males, whereas it did not change in females. Nicotine 54-62 vascular endothelial growth factor A Rattus norvegicus 9-13 31578682-10 2019 The use of nicotine made VEGF and MMP2 levels increase in kidney tissue in both genders of rats. Nicotine 11-19 vascular endothelial growth factor A Rattus norvegicus 25-29 22245234-0 2012 Maternal nicotine effects on vascular endothelial growth factor expression and morphometry in rat lungs. Nicotine 9-17 vascular endothelial growth factor A Rattus norvegicus 29-63 30518184-1 2018 The nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK; nicotine derived nitrosamine ketone) is one of the strongest carcinogens in tobacco which is involved in induction of lung cancer by changing the stimulation of vascular endothelial growth factor (VEGF) and annexin A2 expression. Nicotine 69-77 vascular endothelial growth factor A Rattus norvegicus 266-270 29345720-0 2018 Effects of nicotine administration in rats on MMP2 and VEGF levels in periodontal membrane. Nicotine 11-19 vascular endothelial growth factor A Rattus norvegicus 55-59 29345720-2 2018 This article aimed at identifying the expression of matrix metalloproteinases 2 (MMPs2) and vascular endothelial growth factor (VEGF) proteins on extracellular matrix, fibrous distribution and angiogenetic development in periodontitis caused by nicotine effects on periodontal membrane. Nicotine 245-253 vascular endothelial growth factor A Rattus norvegicus 92-126 29345720-2 2018 This article aimed at identifying the expression of matrix metalloproteinases 2 (MMPs2) and vascular endothelial growth factor (VEGF) proteins on extracellular matrix, fibrous distribution and angiogenetic development in periodontitis caused by nicotine effects on periodontal membrane. Nicotine 245-253 vascular endothelial growth factor A Rattus norvegicus 128-132 28277073-0 2017 Enhancement of vascular endothelial growth factor"s angiogenic capacity by the therapeutic modulation of notch signalling improves tram flap survival in rats submitted to nicotine. Nicotine 171-179 vascular endothelial growth factor A Rattus norvegicus 15-49 28277073-2 2017 Considering that Notch signalling through its ligand Delta-like 4 (Dll4) functions as anti-angiogenic factor by inhibiting the pro-angiogenic effects of vascular endothelial growth factor (VEGF), it is hypothesised that inhibition of the Notch would promote angiogenesis and increase TRAM flap survival in rats submitted to nicotine. Nicotine 324-332 vascular endothelial growth factor A Rattus norvegicus 189-193 28277073-15 2017 CONCLUSION: Notch inhibition significantly improved TRAM flap survival in animals exposed to nicotine by promoting VEGF-induced angiogenesis. Nicotine 93-101 vascular endothelial growth factor A Rattus norvegicus 115-119 27363062-11 2016 CONCLUSION: The increased level of VEGF expression in the nicotine-treated group may have affected endothelial cell apoptosis. Nicotine 58-66 vascular endothelial growth factor A Rattus norvegicus 35-39 22245234-2 2012 We evaluated the effects of maternal nicotine exposure on lung VEGF expression and morphometry during the postnatal period in rats. Nicotine 37-45 vascular endothelial growth factor A Rattus norvegicus 63-67 22245234-7 2012 Nicotine exposure caused a significant decrease in vascular endothelial growth factor receptor (VEGFR)-2 mRNA expression, compared with the level of the control rats on Postnatal Day 1. Nicotine 0-8 vascular endothelial growth factor A Rattus norvegicus 51-85 22245234-9 2012 CONCLUSIONS: Maternal nicotine exposure during pregnancy decreases VEGF and VEGFR-2 mRNA expression and alters lung structure in the lungs of postnatal rats. Nicotine 22-30 vascular endothelial growth factor A Rattus norvegicus 67-71 22245234-10 2012 Because angiogenesis is vital for alveolarization during normal lung development, these results suggest that decreased VEGF expression might be involved in the structural alterations of the developing lung after exposure to antenatal nicotine. Nicotine 234-242 vascular endothelial growth factor A Rattus norvegicus 119-123 18789935-3 2008 Immunohistochemical analysis revealed that alcohol and nicotine consumption increased MAC deposition and VEGF expression in laser spots. Nicotine 55-63 vascular endothelial growth factor A Rattus norvegicus 105-109 17286987-0 2007 Nicotine-induced vascular endothelial growth factor release via the EGFR-ERK pathway in rat vascular smooth muscle cells. Nicotine 0-8 vascular endothelial growth factor A Rattus norvegicus 17-51 17286987-3 2007 In the present study, we investigated the effects of nicotine, which is one of the important constituents of cigarette smoke, on vascular endothelial growth factor (VEGF) release, in rat VSMC. Nicotine 53-61 vascular endothelial growth factor A Rattus norvegicus 129-163 17286987-3 2007 In the present study, we investigated the effects of nicotine, which is one of the important constituents of cigarette smoke, on vascular endothelial growth factor (VEGF) release, in rat VSMC. Nicotine 53-61 vascular endothelial growth factor A Rattus norvegicus 165-169 17286987-4 2007 The stimulation of cells with nicotine resulted in a time- and concentration-dependent release of VEGF. Nicotine 30-38 vascular endothelial growth factor A Rattus norvegicus 98-102 17286987-5 2007 Hexamethonium, an antagonist of nicotinic acetylcholine receptor (nAChR), inhibited nicotine-induced VEGF release. Nicotine 84-92 vascular endothelial growth factor A Rattus norvegicus 101-105 17286987-6 2007 We next investigated the mechanisms by which nicotine induces VEGF release in the cells. Nicotine 45-53 vascular endothelial growth factor A Rattus norvegicus 62-66 17286987-7 2007 The nicotine-induced VEGF release was inhibited by treatment with U0126, a selective inhibitor of MEK, which attenuated the nicotine-induced ERK phosphorylation. Nicotine 4-12 vascular endothelial growth factor A Rattus norvegicus 21-25 17286987-7 2007 The nicotine-induced VEGF release was inhibited by treatment with U0126, a selective inhibitor of MEK, which attenuated the nicotine-induced ERK phosphorylation. Nicotine 124-132 vascular endothelial growth factor A Rattus norvegicus 21-25 17286987-9 2007 Furthermore, AG1478, a selective inhibitor of epidermal growth factor receptor (EGFR) kinase, inhibited nicotine-induced ERK phosphorylation and VEGF release. Nicotine 104-112 vascular endothelial growth factor A Rattus norvegicus 145-149 17286987-10 2007 These data suggest that nicotine releases VEGF through nAChR in VSMC. Nicotine 24-32 vascular endothelial growth factor A Rattus norvegicus 42-46 17286987-11 2007 Moreover, VEGF release induced by nicotine is mediated by an EGFR-ERK pathway in VSMC. Nicotine 34-42 vascular endothelial growth factor A Rattus norvegicus 10-14 16499655-0 2006 Perinatal expression of HSP70 and VEGF in neonatal rat lung vessels exposed to nicotine during gestation. Nicotine 79-87 vascular endothelial growth factor A Rattus norvegicus 34-38 16499655-1 2006 We assessed the influence of maternal nicotine exposure during gestation on perinatal expression of HSP70 and VEGF in rat lung parenchyma and lung vessels. Nicotine 38-46 vascular endothelial growth factor A Rattus norvegicus 110-114 16499655-8 2006 In conclusion, gestational nicotine exposure increased the expression of VEGF and HSP70 in rat lung parenchyma, especially in the airway epithelium and vascular smooth muscle cells. Nicotine 27-35 vascular endothelial growth factor A Rattus norvegicus 73-77 22403787-5 2012 Moreover, a common HIF target, VEGF mRNA, was also upregulated after chronic nicotine. Nicotine 77-85 vascular endothelial growth factor A Rattus norvegicus 31-35 21330654-0 2011 Nicotine increases the VEGF/PEDF ratio in retinal pigment epithelium: a possible mechanism for CNV in passive smokers with AMD. Nicotine 0-8 vascular endothelial growth factor A Rattus norvegicus 23-27 21378373-0 2011 Fetal and neonatal exposure to nicotine disrupts postnatal lung development in rats: role of VEGF and its receptors. Nicotine 31-39 vascular endothelial growth factor A Rattus norvegicus 93-97 21378373-8 2011 The current study suggests that perinatal exposure to nicotine alters lung development, an effect which may be mediated via decreased vascular endothelial growth factor (VEGF) signaling. Nicotine 54-62 vascular endothelial growth factor A Rattus norvegicus 134-168 21378373-8 2011 The current study suggests that perinatal exposure to nicotine alters lung development, an effect which may be mediated via decreased vascular endothelial growth factor (VEGF) signaling. Nicotine 54-62 vascular endothelial growth factor A Rattus norvegicus 170-174