PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
14575895-0	2003	Effect of nicotine on the expression of leptin and forebrain leptin receptors in the rat.	Nicotine	10-18	leptin	Rattus norvegicus	40-46	
14575895-0	2003	Effect of nicotine on the expression of leptin and forebrain leptin receptors in the rat.	Nicotine	10-18	leptin	Rattus norvegicus	61-67	
14575895-3	2003	Since there exists a coregulation between these neuropeptides and the protein leptin, the present study was undertaken to determine whether nicotine has a regulatory effect on leptin signaling.	Nicotine	140-148	leptin	Rattus norvegicus	176-182	
14575895-4	2003	Under the same experimental regimen used previously, we found that nicotine down-regulates plasma leptin concentration by 48.8% (P<0.001) and leptin RNA level by 11.4% and 12.4%, respectively, in the perirenal and epididymal white adipose tissue (PWAT, EWAT) compared to the saline controls.	Nicotine	67-75	leptin	Rattus norvegicus	98-104	
14575895-4	2003	Under the same experimental regimen used previously, we found that nicotine down-regulates plasma leptin concentration by 48.8% (P<0.001) and leptin RNA level by 11.4% and 12.4%, respectively, in the perirenal and epididymal white adipose tissue (PWAT, EWAT) compared to the saline controls.	Nicotine	67-75	leptin	Rattus norvegicus	145-151	
14575895-7	2003	Subsequent radioligand binding assays indicated that nicotine also significantly increased leptin binding in ventromedial hypothalamic area (VMA), medial basal hypothalamic area (MBA), arcuate nucleus/median eminence, paraventricular nuclei and piriform cortex.	Nicotine	53-61	leptin	Rattus norvegicus	91-97	
14575895-8	2003	Taken together, our results revealed that nicotine is involved in the regulation of leptin signaling, suggesting that leptin and its receptor play a role in the anorectic effects of nicotine on food intake and body weight in rats.	Nicotine	42-50	leptin	Rattus norvegicus	84-90	
14575895-8	2003	Taken together, our results revealed that nicotine is involved in the regulation of leptin signaling, suggesting that leptin and its receptor play a role in the anorectic effects of nicotine on food intake and body weight in rats.	Nicotine	42-50	leptin	Rattus norvegicus	118-124	
14575895-8	2003	Taken together, our results revealed that nicotine is involved in the regulation of leptin signaling, suggesting that leptin and its receptor play a role in the anorectic effects of nicotine on food intake and body weight in rats.	Nicotine	182-190	leptin	Rattus norvegicus	84-90	
14575895-8	2003	Taken together, our results revealed that nicotine is involved in the regulation of leptin signaling, suggesting that leptin and its receptor play a role in the anorectic effects of nicotine on food intake and body weight in rats.	Nicotine	182-190	leptin	Rattus norvegicus	118-124	
11350768-0	2001	Nicotine infusion alters leptin and uncoupling protein 1 mRNA expression in adipose tissues of rats.	Nicotine	0-8	leptin	Rattus norvegicus	25-31	
11350768-1	2001	We attempted to clarify whether leptin and uncoupling protein 1 (UCP1) are involved in the action of nicotine on the energy balance.	Nicotine	101-109	leptin	Rattus norvegicus	32-38	
11350768-3	2001	At the end of the 4-day period, the plasma concentrations of leptin of the nicotine-treated and pair-fed rats were lower than those of the freely fed rats, although the levels of leptin mRNA expression in various white adipose tissues did not differ among the three groups.	Nicotine	75-83	leptin	Rattus norvegicus	61-67	
11350768-3	2001	At the end of the 4-day period, the plasma concentrations of leptin of the nicotine-treated and pair-fed rats were lower than those of the freely fed rats, although the levels of leptin mRNA expression in various white adipose tissues did not differ among the three groups.	Nicotine	75-83	leptin	Rattus norvegicus	179-185	
11350768-4	2001	At the end of the 14-day nicotine infusion period, plasma concentrations of leptin were higher, and leptin mRNA expression in the omentum and epididymal and retroperitoneal adipose tissues was stronger in the nicotine-treated rats than in the pair-fed and freely fed rats.	Nicotine	25-33	leptin	Rattus norvegicus	76-82	
11350768-4	2001	At the end of the 14-day nicotine infusion period, plasma concentrations of leptin were higher, and leptin mRNA expression in the omentum and epididymal and retroperitoneal adipose tissues was stronger in the nicotine-treated rats than in the pair-fed and freely fed rats.	Nicotine	25-33	leptin	Rattus norvegicus	100-106	
11350768-4	2001	At the end of the 14-day nicotine infusion period, plasma concentrations of leptin were higher, and leptin mRNA expression in the omentum and epididymal and retroperitoneal adipose tissues was stronger in the nicotine-treated rats than in the pair-fed and freely fed rats.	Nicotine	209-217	leptin	Rattus norvegicus	100-106	
11350768-6	2001	These results suggest that continuous nicotine infusion differentially affects the synthesis and secretion of leptin according to the duration of infusion and stimulates UCP1 mRNA expression, probably in a manner independent of leptin.	Nicotine	38-46	leptin	Rattus norvegicus	110-116	
11350768-6	2001	These results suggest that continuous nicotine infusion differentially affects the synthesis and secretion of leptin according to the duration of infusion and stimulates UCP1 mRNA expression, probably in a manner independent of leptin.	Nicotine	38-46	leptin	Rattus norvegicus	228-234	
33002592-8	2020	Higher doses of nicotine were associated with higher glucose, HbA1c, leptin, IL-6, MDA and lipids levels, while, insulin, adiponectin, G6PDH, hexokinase and HDL levels were lower.	Nicotine	16-24	leptin	Rattus norvegicus	69-75	
19067528-4	2008	We used a smokeless tobacco model to study leptin responses to nicotine or placebo treatment.	Nicotine	63-71	leptin	Rattus norvegicus	43-49