PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24095726-0	2013	A functional link between heme oxygenase-1 and tristetraprolin in the anti-inflammatory effects of nicotine.	Nicotine	99-107	zinc finger protein 36	Mus musculus	47-62	
24095726-8	2013	Downregulation of STAT3 by siRNA attenuated the effect of nicotine on TTP expression and TNF-alpha production but did not affect the nicotine-mediated induction of HO-1.	Nicotine	58-66	zinc finger protein 36	Mus musculus	70-73	
24095726-9	2013	In TTP knockout mice, nicotine treatment enhanced HO-1 expression and STAT3 activation but failed to inhibit LPS-induced TNF-alpha production.	Nicotine	22-30	zinc finger protein 36	Mus musculus	3-6	
24095726-10	2013	Our results suggest that HO-1 and TTP are functionally linked in mediating the anti-inflammatory effects of nicotine; HO-1 is necessary for the induction of TTP by nicotine.	Nicotine	108-116	zinc finger protein 36	Mus musculus	34-37	
24095726-2	2013	We have previously reported that heme oxygenase-1 (HO-1) and tristetraprolin (TTP) are induced by nicotine and mediate the anti-inflammatory function of nicotine in macrophages.	Nicotine	98-106	zinc finger protein 36	Mus musculus	61-76	
24095726-2	2013	We have previously reported that heme oxygenase-1 (HO-1) and tristetraprolin (TTP) are induced by nicotine and mediate the anti-inflammatory function of nicotine in macrophages.	Nicotine	98-106	zinc finger protein 36	Mus musculus	78-81	
24095726-2	2013	We have previously reported that heme oxygenase-1 (HO-1) and tristetraprolin (TTP) are induced by nicotine and mediate the anti-inflammatory function of nicotine in macrophages.	Nicotine	153-161	zinc finger protein 36	Mus musculus	61-76	
24095726-2	2013	We have previously reported that heme oxygenase-1 (HO-1) and tristetraprolin (TTP) are induced by nicotine and mediate the anti-inflammatory function of nicotine in macrophages.	Nicotine	153-161	zinc finger protein 36	Mus musculus	78-81	
24095726-4	2013	In this study, we sought to determine whether HO-1 associates with TTP to mediate the anti-inflammatory effects of nicotine.	Nicotine	115-123	zinc finger protein 36	Mus musculus	67-70	
24095726-7	2013	In an LPS-induced endotoxemia model, HO-1 deficiency blocked the effects of nicotine on the STAT3 phosphorylation, TTP induction, and LPS-induced TNF-alpha production in the liver.	Nicotine	76-84	zinc finger protein 36	Mus musculus	115-118	
22093924-3	2012	In muscles and C2C12 myotubes, cholinergic excitation by exposure to nicotine or the organophosphorous pesticide, Paraoxon, induced Tristetraprolin overproduction while reducing pro-inflammatory transcripts such as IL-6, CXCL1 (KC) and CCL2 (MCP-1).	Nicotine	69-77	zinc finger protein 36	Mus musculus	132-147	
22093924-5	2012	Tristetraprolin was essential for this anti-inflammatory effect of nicotine in basal conditions.	Nicotine	67-75	zinc finger protein 36	Mus musculus	0-15