PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26135009-7	2015	Chemical inhibition of UGT enzymes in HLM demonstrated that nicotine (UGT2B10 inhibitor) but not hecogenin (UGT1A4 inhibitor) completely inhibited the conversion of desloratadine (1 microM) to 3-hydroxydesloratadine in HLM fortified with both NADPH and UDP-glucuronic acid.	Nicotine	60-68	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	23-26	
21497036-1	2011	Nicotine is considered to be a specific substrate for UGT2B10, an isoform of human uridine diphosphate glucuronosyltransferase (UGT).	Nicotine	0-8	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	83-126	
21497036-1	2011	Nicotine is considered to be a specific substrate for UGT2B10, an isoform of human uridine diphosphate glucuronosyltransferase (UGT).	Nicotine	0-8	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	54-57	
14570768-12	2003	Interestingly, when expressed per UGT1A protein, measured by a UGT1A specific antibody, cell lysate from V79-expressed UGT1A9 catalyzed nicotine glucuronidation at a rate 17-fold greater than did UGT1A9 Supersomes.	Nicotine	136-144	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	63-68	
19803778-6	2009	These findings suggest that genetic variation in UGT isoenzymes that act in additive and interactive ways is an important determinant of individual variability in nicotine and cotinine metabolism via glucuronidation pathways.	Nicotine	163-171	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	49-52	
17576790-8	2007	These novel findings solve two seemingly separate questions: which UGT is primarily responsible for nicotine glucuronidation in human liver, and what conjugation reactions are catalyzed by UGT2B10.	Nicotine	100-108	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	67-70	
14570768-12	2003	Interestingly, when expressed per UGT1A protein, measured by a UGT1A specific antibody, cell lysate from V79-expressed UGT1A9 catalyzed nicotine glucuronidation at a rate 17-fold greater than did UGT1A9 Supersomes.	Nicotine	136-144	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	34-39	
12167564-9	2002	It would appear that the same, as yet unexamined, UGT catalyzes the N-glucuronidation of both cotinine and nicotine.	Nicotine	107-115	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	50-53	
12433823-10	2002	In conclusion, the involvement of UGT1A1 and UGT1A9 as well as UGT1A4 in nicotine and cotinine N-glucuronidations in human liver microsomes was suggested, although the contributions of each UGT isoform could not be determined conclusively.	Nicotine	73-81	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	34-37