PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2587602-3 1989 To determine whether the nicotine-induced body weight reductions are associated with endocrinological changes, the levels of gastrin and CCK in plasma were measured by specific radioimmunoassays and were found significantly elevated during chronic ingestion of nicotine. Nicotine 25-33 cholecystokinin Rattus norvegicus 137-140 18822160-8 2008 CCK-stimulated cell function induced by nicotine was significantly higher in AR42J cells as compared to the response by H2O2. Nicotine 40-48 cholecystokinin Rattus norvegicus 0-3 16051920-9 2005 At a nicotine dose of 100 microM, the CCK-stimulated release of amylase was maximal at 6 min, and, although a nicotinic receptor antagonist inhibited this response, it was not inhibited by the ERK1/2 pathway inhibitor. Nicotine 5-13 cholecystokinin Rattus norvegicus 38-41 1690423-4 1990 Endocrinological studies showed that the plasma levels of CCK were significantly increased with nicotine but the amylase secretory response of pancreatic acinar cells was inhibited in response to CCK-8 and carbachol. Nicotine 96-104 cholecystokinin Rattus norvegicus 58-61 1690423-9 1990 In addition, plasma CCK levels and pancreatic enzyme secretion were reversed upon nicotine withdrawal. Nicotine 82-90 cholecystokinin Rattus norvegicus 20-23 15158017-0 2004 Cholecystokinin and prostaglandins inhibit responses of vagal afferent activity to systemic administration of nicotine in anesthetized rats. Nicotine 110-118 cholecystokinin Rattus norvegicus 0-15 15158017-2 2004 Since gastric vagal afferents convey satiation signals to the hypothalamus in response to cholecystokinin, we investigated the possibility that nicotine increases afferent activity of the gastric vagal nerves by stimulating release of cholecystokinin. Nicotine 144-152 cholecystokinin Rattus norvegicus 235-250 15158017-9 2004 These results suggest that nicotine can exert its anorexic effect via an increase in gastric vagal afferent activity which is caused by enhanced release of both cholecystokinin and prostaglandins. Nicotine 27-35 cholecystokinin Rattus norvegicus 161-176 11851194-8 2001 In response to CCK-8, amylase release was decreased by nicotine and by mecamylamine (100 microM) when compared with control. Nicotine 55-63 cholecystokinin Rattus norvegicus 15-18 11851194-10 2001 Peak amylase released with the maximal dose of CCK-8 (1 x 10(-10) M) was less in cells treated with nicotine when compared with those measured cells treated with saline or with the two doses of mecamylamine. Nicotine 100-108 cholecystokinin Rattus norvegicus 47-50 11851194-13 2001 Both of these drugs, nicotine and mecamylamine, may act via CCK receptors via two different intracellular mechanisms. Nicotine 21-29 cholecystokinin Rattus norvegicus 60-63 2587602-3 1989 To determine whether the nicotine-induced body weight reductions are associated with endocrinological changes, the levels of gastrin and CCK in plasma were measured by specific radioimmunoassays and were found significantly elevated during chronic ingestion of nicotine. Nicotine 261-269 cholecystokinin Rattus norvegicus 137-140 2481202-0 1989 Inhibition of CCK or carbachol-stimulated amylase release by nicotine. Nicotine 61-69 cholecystokinin Rattus norvegicus 14-17 2481202-4 1989 Cells from the nicotine treated animals(16 weeks in drinking water) were incubated with either a fixed dose of CCK-8(10(-10) M) or carbachol(10(-5) M). Nicotine 15-23 cholecystokinin Rattus norvegicus 111-114 2481202-8 1989 Acinar cells isolated from rats treated with nicotine at nicotine concentrations of 1.23 mM also showed significant inhibition of amylase release in response to CCK-8 and carbachol compared to their identical controls. Nicotine 45-53 cholecystokinin Rattus norvegicus 161-164 2481202-8 1989 Acinar cells isolated from rats treated with nicotine at nicotine concentrations of 1.23 mM also showed significant inhibition of amylase release in response to CCK-8 and carbachol compared to their identical controls. Nicotine 57-65 cholecystokinin Rattus norvegicus 161-164