PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2587602-3	1989	To determine whether the nicotine-induced body weight reductions are associated with endocrinological changes, the levels of gastrin and CCK in plasma were measured by specific radioimmunoassays and were found significantly elevated during chronic ingestion of nicotine.	Nicotine	25-33	cholecystokinin	Rattus norvegicus	137-140	
2587602-3	1989	To determine whether the nicotine-induced body weight reductions are associated with endocrinological changes, the levels of gastrin and CCK in plasma were measured by specific radioimmunoassays and were found significantly elevated during chronic ingestion of nicotine.	Nicotine	261-269	cholecystokinin	Rattus norvegicus	137-140	
15158017-0	2004	Cholecystokinin and prostaglandins inhibit responses of vagal afferent activity to systemic administration of nicotine in anesthetized rats.	Nicotine	110-118	cholecystokinin	Rattus norvegicus	0-15	
2481202-0	1989	Inhibition of CCK or carbachol-stimulated amylase release by nicotine.	Nicotine	61-69	cholecystokinin	Rattus norvegicus	14-17	
2481202-4	1989	Cells from the nicotine treated animals(16 weeks in drinking water) were incubated with either a fixed dose of CCK-8(10(-10) M) or carbachol(10(-5) M).	Nicotine	15-23	cholecystokinin	Rattus norvegicus	111-114	
2481202-8	1989	Acinar cells isolated from rats treated with nicotine at nicotine concentrations of 1.23 mM also showed significant inhibition of amylase release in response to CCK-8 and carbachol compared to their identical controls.	Nicotine	45-53	cholecystokinin	Rattus norvegicus	161-164	
2481202-8	1989	Acinar cells isolated from rats treated with nicotine at nicotine concentrations of 1.23 mM also showed significant inhibition of amylase release in response to CCK-8 and carbachol compared to their identical controls.	Nicotine	57-65	cholecystokinin	Rattus norvegicus	161-164	
18822160-8	2008	CCK-stimulated cell function induced by nicotine was significantly higher in AR42J cells as compared to the response by H2O2.	Nicotine	40-48	cholecystokinin	Rattus norvegicus	0-3	
16051920-9	2005	At a nicotine dose of 100 microM, the CCK-stimulated release of amylase was maximal at 6 min, and, although a nicotinic receptor antagonist inhibited this response, it was not inhibited by the ERK1/2 pathway inhibitor.	Nicotine	5-13	cholecystokinin	Rattus norvegicus	38-41	
15158017-2	2004	Since gastric vagal afferents convey satiation signals to the hypothalamus in response to cholecystokinin, we investigated the possibility that nicotine increases afferent activity of the gastric vagal nerves by stimulating release of cholecystokinin.	Nicotine	144-152	cholecystokinin	Rattus norvegicus	235-250	
15158017-9	2004	These results suggest that nicotine can exert its anorexic effect via an increase in gastric vagal afferent activity which is caused by enhanced release of both cholecystokinin and prostaglandins.	Nicotine	27-35	cholecystokinin	Rattus norvegicus	161-176	
11851194-8	2001	In response to CCK-8, amylase release was decreased by nicotine and by mecamylamine (100 microM) when compared with control.	Nicotine	55-63	cholecystokinin	Rattus norvegicus	15-18	
11851194-10	2001	Peak amylase released with the maximal dose of CCK-8 (1 x 10(-10) M) was less in cells treated with nicotine when compared with those measured cells treated with saline or with the two doses of mecamylamine.	Nicotine	100-108	cholecystokinin	Rattus norvegicus	47-50	
11851194-13	2001	Both of these drugs, nicotine and mecamylamine, may act via CCK receptors via two different intracellular mechanisms.	Nicotine	21-29	cholecystokinin	Rattus norvegicus	60-63	
1690423-4	1990	Endocrinological studies showed that the plasma levels of CCK were significantly increased with nicotine but the amylase secretory response of pancreatic acinar cells was inhibited in response to CCK-8 and carbachol.	Nicotine	96-104	cholecystokinin	Rattus norvegicus	58-61	
1690423-9	1990	In addition, plasma CCK levels and pancreatic enzyme secretion were reversed upon nicotine withdrawal.	Nicotine	82-90	cholecystokinin	Rattus norvegicus	20-23