PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27656031-0	2016	Stress-Induced Reinstatement of Nicotine Preference Requires Dynorphin/Kappa Opioid Activity in the Basolateral Amygdala.	Nicotine	32-40	prodynorphin	Mus musculus	61-70	
27656031-11	2016	Considered together, our findings suggest that activation of the DYN/KOR system and Galphai signaling within the BLA is both necessary and sufficient to produce reinstatement of nicotine preference.	Nicotine	178-186	prodynorphin	Mus musculus	65-68	
27656031-15	2016	Here, we report region-specific engagement of the DYN/KOR system and subsequent activation of inhibitory (Gi-linked) intracellular signaling pathways within the basolateral amygdala during stress-induced reinstatement of nicotine preference.	Nicotine	221-229	prodynorphin	Mus musculus	50-53	
18807250-0	2009	Acute nicotine changes dynorphin and prodynorphin mRNA in the striatum.	Nicotine	6-14	prodynorphin	Mus musculus	23-32	
18937881-0	2009	Prodynorphin gene disruption increases the sensitivity to nicotine self-administration in mice.	Nicotine	58-66	prodynorphin	Mus musculus	0-12	
18937881-2	2009	The aim of the study was to determine the contribution of the endogenous peptides derived from prodynorphin in acute and chronic nicotine responses, mainly those related to its addictive properties.	Nicotine	129-137	prodynorphin	Mus musculus	95-107	
18937881-8	2009	However, a shift to the left in the percentage of acquisition of intravenous nicotine-self administration was observed in prodynorphin KO mice.	Nicotine	77-85	prodynorphin	Mus musculus	122-134	
18937881-11	2009	These findings reveal a specific role of endogenous peptides derived from prodynorphin in nicotine self-administration, probably through the modulation of its aversive effects.	Nicotine	90-98	prodynorphin	Mus musculus	74-86	
18807250-0	2009	Acute nicotine changes dynorphin and prodynorphin mRNA in the striatum.	Nicotine	6-14	prodynorphin	Mus musculus	37-49	
18807250-3	2009	OBJECTIVE: We determined whether administration of a single dose of nicotine alters the biosynthesis of Dyn in the striatum of mice.	Nicotine	68-76	prodynorphin	Mus musculus	104-107	
18807250-4	2009	RESULTS: Nicotine free base, 1 mg/kg, sc, induced a biphasic, protracted increase of striatal Dyn, an initial rise by 1 h, which declined to control levels by 2 h, and a subsequent increase, between 6 and 12 h, lasting over 24 h. At 1 h, the nicotine effect was dose dependent, with doses>or=0.5 mg/kg inducing a response.	Nicotine	9-17	prodynorphin	Mus musculus	94-97	
18807250-7	2009	The glutamate NMDA receptor antagonist MK-801 reversed the nicotine-induced increase of Dyn, while the AMPA antagonist NBQX had a marginal effect.	Nicotine	59-67	prodynorphin	Mus musculus	88-91	
18807250-8	2009	CONCLUSIONS: We interpret our findings to indicate that acute nicotine enhances the synthesis and release of striatal Dyn.	Nicotine	62-70	prodynorphin	Mus musculus	118-121	
18807250-9	2009	We propose that nicotine influences Dyn primarily through dopamine release and that glutamate plays a modulatory role.	Nicotine	16-24	prodynorphin	Mus musculus	36-39	
15542756-0	2004	Alpha 7-type nicotinic acetylcholine receptor and prodynorphin mRNA expression after administration of (-)-nicotine and U-50,488H in beta-amyloid peptide (25-35)-treated mice.	Nicotine	103-115	prodynorphin	Mus musculus	50-62	
18361441-0	2008	Dynorphin and prodynorphin mRNA changes in the striatum during nicotine withdrawal.	Nicotine	63-71	prodynorphin	Mus musculus	14-26	
18361441-3	2008	In this regard, the opioid dynorphin (Dyn) is of interest as it produces aversive states and has been speculated to play a role in the nicotine behavioral syndrome.	Nicotine	135-143	prodynorphin	Mus musculus	38-41	
18361441-4	2008	These studies explore whether Dyn metabolism is altered during withdrawal following chronic administration of nicotine.	Nicotine	110-118	prodynorphin	Mus musculus	30-33	
15542756-3	2004	In the present study, we tested whether (-)-nicotine and U-50,488H prevent delayed-memory impairment induced by beta-amyloid peptide (25-35), and changes of expression of alpha7-type nicotinic acetylcholine receptor mRNA and prodynorphin mRNA.	Nicotine	40-52	prodynorphin	Mus musculus	225-237