PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34378958-3 2021 Based on a previous genomic and transcriptomic analysis, an open reading frame (ORF) annotated to encode aldehyde dehydrogenase (Ald) in the nicotine-degrading cluster was predicted to be responsible for this step. Nicotine 141-149 AWN88_RS16050 Agrobacterium tumefaciens 105-127 34378958-3 2021 Based on a previous genomic and transcriptomic analysis, an open reading frame (ORF) annotated to encode aldehyde dehydrogenase (Ald) in the nicotine-degrading cluster was predicted to be responsible for this step. Nicotine 141-149 AWN88_RS16050 Agrobacterium tumefaciens 129-132 34378958-8 2021 Disruption of the ald gene caused a lower growth rate and biomass of strain S33 on nicotine but not on 6-hydroxy-3-succinoylpyridine. Nicotine 83-91 AWN88_RS16050 Agrobacterium tumefaciens 18-21 34378958-11 2021 These findings provide new insights into the biochemical mechanism of the nicotine-degrading hybrid pathway and the possible application of Ald in industrial biocatalysis. Nicotine 74-82 AWN88_RS16050 Agrobacterium tumefaciens 140-143