PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12162440-10 2002 Both H2O2 and TNF-alpha significantly increased IL-8 release, which was further enhanced by pre-treatment of A549 cells with TSA compared to the individual treatments. trichostatin A 125-128 C-X-C motif chemokine ligand 8 Homo sapiens 48-52 18669446-3 2008 Treatment of MCF-7 cells with the HDAC inhibitor trichostatin A (TSA) led to a strong up-regulation of IL-8 protein and RNA levels in MCF-7 cells. trichostatin A 49-63 C-X-C motif chemokine ligand 8 Homo sapiens 103-107 18669446-3 2008 Treatment of MCF-7 cells with the HDAC inhibitor trichostatin A (TSA) led to a strong up-regulation of IL-8 protein and RNA levels in MCF-7 cells. trichostatin A 65-68 C-X-C motif chemokine ligand 8 Homo sapiens 103-107 18669446-9 2008 TSA increased binding of acetylated histone 3 to the IL-8 gene promoter. trichostatin A 0-3 C-X-C motif chemokine ligand 8 Homo sapiens 53-57 17711487-3 2007 The effect of the histone deacetylase inhibitor trichostatin A (TSA) on LPS- and TNF-alpha-induced IL-8 release and its repression by glucocorticoids was also examined. trichostatin A 48-62 C-X-C motif chemokine ligand 8 Homo sapiens 99-103 17711487-3 2007 The effect of the histone deacetylase inhibitor trichostatin A (TSA) on LPS- and TNF-alpha-induced IL-8 release and its repression by glucocorticoids was also examined. trichostatin A 64-67 C-X-C motif chemokine ligand 8 Homo sapiens 99-103 17711487-5 2007 Pretreatment of cells with TSA enhanced basal and LPS- and TNFalpha-stimulated IL-8 release in all three cell lines. trichostatin A 27-30 C-X-C motif chemokine ligand 8 Homo sapiens 79-83 17711487-6 2007 TSA also attenuated the inhibitory effect of glucocorticoids on stimulated IL-8 release. trichostatin A 0-3 C-X-C motif chemokine ligand 8 Homo sapiens 75-79 16306601-10 2005 Treatment with the HDAC inhibitor trichostatin A blocks attenuation of IL-8 transcription. trichostatin A 34-48 C-X-C motif chemokine ligand 8 Homo sapiens 71-75 15337792-6 2004 Theophylline induced a sixfold increase in HDAC activity in COPD AM lysates and significantly enhanced dexamethasone suppression of induced IL-8 release, an effect that was blocked by the HDAC inhibitor trichostatin A. trichostatin A 203-217 C-X-C motif chemokine ligand 8 Homo sapiens 140-144 12573991-5 2003 PM(10) and H(2)O(2) increased IL-8 protein release from A549 cells after 24-h treatment, and this was enhanced by histone deacetylase inhibition by trichostatin A (cotreatment). trichostatin A 148-162 C-X-C motif chemokine ligand 8 Homo sapiens 30-34 11564889-8 2001 Finally, we show that inhibition of HDAC activity with TSA causes an increase in both basal and TNF-induced expression of the NF-kappaB-regulated interleukin-8 (IL-8) gene. trichostatin A 55-58 C-X-C motif chemokine ligand 8 Homo sapiens 146-159 12010777-13 2002 TSA rapidly induced H4 acetylation in IL-8 promoter chromatin, whereas caprylic acid did not. trichostatin A 0-3 C-X-C motif chemokine ligand 8 Homo sapiens 38-42 12010777-14 2002 These results suggest that the inhibition of IL-8 gene transcription induced by caprylic acid and TSA does not necessarily require the marked suppression of transcription factors, and the mechanism of inhibition of IL-8 gene transcription may be different between caprylic acid and TSA. trichostatin A 98-101 C-X-C motif chemokine ligand 8 Homo sapiens 45-49 12010777-14 2002 These results suggest that the inhibition of IL-8 gene transcription induced by caprylic acid and TSA does not necessarily require the marked suppression of transcription factors, and the mechanism of inhibition of IL-8 gene transcription may be different between caprylic acid and TSA. trichostatin A 282-285 C-X-C motif chemokine ligand 8 Homo sapiens 45-49 11564889-8 2001 Finally, we show that inhibition of HDAC activity with TSA causes an increase in both basal and TNF-induced expression of the NF-kappaB-regulated interleukin-8 (IL-8) gene. trichostatin A 55-58 C-X-C motif chemokine ligand 8 Homo sapiens 161-165 11564889-9 2001 Similar to the wild-type integrated NF-kappaB-dependent reporter, ChIP assays showed that TSA treatment resulted in hyperacetylation of the IL-8 promoter. trichostatin A 90-93 C-X-C motif chemokine ligand 8 Homo sapiens 140-144 34785925-8 2021 Furthermore, blocking Stat3 signaling pathway by treatment with TSA and/or small molecule compound Stattic of an p-Stat3 inhibitor effectively abrogated LPS-induced tumorosphere forming with decrease of IL-6, IL-8 and stemness biomarkers CD44, SOX-2 expression. trichostatin A 64-67 C-X-C motif chemokine ligand 8 Homo sapiens 209-213 21594484-0 1996 Biosynthesis of IL-8 and endothelin-1,2 by immortal simian virus 40 tsA-transformed human endothelial cells. trichostatin A 68-71 C-X-C motif chemokine ligand 8 Homo sapiens 16-20 9067093-6 1997 SCFAs and trichostatin A, structurally unrelated compounds which both induce histone hyperacetylation, both led to a dose-dependent inhibition of IL-8 gene expression. trichostatin A 10-24 C-X-C motif chemokine ligand 8 Homo sapiens 146-150 34785925-10 2021 TSA could prevent, at least in part, the LPS-induced malignant transformation by targeting p-Stat3/c-Myc signaling pathway and reducing inflammatory IL-6, IL-8. trichostatin A 0-3 C-X-C motif chemokine ligand 8 Homo sapiens 155-159 33671042-8 2021 Butyrate (0.1 mM), propionate (0.3 mM), and TSA inhibited the IL-8 production and activation of NF-kappaB. trichostatin A 44-47 C-X-C motif chemokine ligand 8 Homo sapiens 62-66 27162363-4 2016 Using an in vitro model of colonic epithelial cells challenged with Escherichia coli K12, we showed that inhibition of histone deacetylases (HDAC) by trichostatin A dramatically enhanced induction of HBD2 expression, without affecting expression of IL-8. trichostatin A 150-164 C-X-C motif chemokine ligand 8 Homo sapiens 249-253 24627774-9 2013 Pretreatment with TSA showed a dose-dependent stimulatory effect on IL-8 release from A549 cells as compared to LPS alone. trichostatin A 18-21 C-X-C motif chemokine ligand 8 Homo sapiens 68-72 29875665-12 2018 TSA showed similar effects on IL-8 production and VCAM-1 expression as butyrate and propionate. trichostatin A 0-3 C-X-C motif chemokine ligand 8 Homo sapiens 30-34 21299717-6 2011 Indeed, chromatin immunoprecipitation (ChIP) analysis showed that events related to transcriptional activation of the IL-8 gene region in response to TNF-alpha, including recruitment of RNA polymerase II (Pol II), were compromised in the presence of TSA. trichostatin A 250-253 C-X-C motif chemokine ligand 8 Homo sapiens 118-122