PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30166563-3 2018 Here, we find that pan-HDACi TSA exerts paradoxical effects on brown fat gene expression, as it inhibits the expression of Ucp1, Ppargamma and Prdm16 in brown adipocytes, while promoting the expression of other brown fat-specific genes such as Pgc1alpha, Pgc1beta, Acox1 and Cidea. trichostatin A 29-32 peroxisome proliferator activated receptor gamma Homo sapiens 129-138 31610471-2 2019 The results showed that trichostatin A and vorinostat changed the relative amounts of H3K9 acetylation and dimethylation in the upstream sequence of PPARG, increased peroxisome proliferator-activated receptor gamma (PPARG) transcription before differentiation and then promoted adipocyte differentiation, and regulated the expression of adipocyte-specific genes. trichostatin A 24-38 peroxisome proliferator activated receptor gamma Homo sapiens 149-154 31610471-2 2019 The results showed that trichostatin A and vorinostat changed the relative amounts of H3K9 acetylation and dimethylation in the upstream sequence of PPARG, increased peroxisome proliferator-activated receptor gamma (PPARG) transcription before differentiation and then promoted adipocyte differentiation, and regulated the expression of adipocyte-specific genes. trichostatin A 24-38 peroxisome proliferator activated receptor gamma Homo sapiens 166-214 31610471-2 2019 The results showed that trichostatin A and vorinostat changed the relative amounts of H3K9 acetylation and dimethylation in the upstream sequence of PPARG, increased peroxisome proliferator-activated receptor gamma (PPARG) transcription before differentiation and then promoted adipocyte differentiation, and regulated the expression of adipocyte-specific genes. trichostatin A 24-38 peroxisome proliferator activated receptor gamma Homo sapiens 216-221 31610471-4 2019 The areas of acetylation and demethylation changed by trichostatin A and vorinostat are the basis for further research on the mechanism of PPARG promoter to regulate adipocytes differentiation and provide research theroies for using adipose-derived stem cells as donor to produce transgenic animals to improve meat quality improvement. trichostatin A 54-68 peroxisome proliferator activated receptor gamma Homo sapiens 139-144 23951179-12 2013 Interestingly, TSA treatment greatly reduced PPARgamma levels in differentiated adipocytes. trichostatin A 15-18 peroxisome proliferator activated receptor gamma Homo sapiens 45-54 27121018-10 2016 Treatment of the HEp-2 cells with genistein and TSA led to a significant reduction in the phosphorylation of Akt and activation of its downstream target, and resulted in peroxisome proliferator-activated receptor-gamma cleavage, increased expression of B cell lymphoma-2 (Bcl-2)-associated X protein and reduced the expression of Bcl-2. trichostatin A 48-51 peroxisome proliferator activated receptor gamma Homo sapiens 170-218 27069916-6 2016 (2) Piperlongumine, 15d-PGJ2 (15-delta prostaglandin J2), vorinostat, and trichostatin A were predicted to be the most promising potential drugs for DN, acting as NF-kappaB inhibitors, histone deacetylase inhibitors (HDACIs), PI3K pathway inhibitors, or PPARgamma agonists, respectively. trichostatin A 74-88 peroxisome proliferator activated receptor gamma Homo sapiens 254-263 25320182-10 2014 Trichostatin A, a specific inhibitor of histone deacetylases (HDACs), enhanced the formation of adipocytes in porcine SVF by nearly 100% and the expression of PPARG and CEBPA mRNAs by 150% and 50%, respectively. trichostatin A 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 159-164 19624894-12 2009 TSA up-regulated the expression of PPARgamma mRNA. trichostatin A 0-3 peroxisome proliferator activated receptor gamma Homo sapiens 35-44 23085045-6 2012 TSA pretreatment, useful experimental protocol to analyse pan-HDAC-chemical inhibition, and switch to osteogenic medium induced early-osteoblast maturation gene Runx2, while transiently decreased PPARgamma and scarcely affected late-differentiation markers. trichostatin A 0-3 peroxisome proliferator activated receptor gamma Homo sapiens 196-205 21057085-8 2010 Moreover, trichostatin A and retinoic acid enhanced the generation of iTregs synergistically with PPARalpha and PPARgamma agonists. trichostatin A 10-24 peroxisome proliferator activated receptor gamma Homo sapiens 112-121 18571164-1 2009 OBJECTIVE: To examine whether trichostatin A (TSA), a histone deacetylase inhibitor (HDACI), can induce up-regulation of peroxisome proliferator-activating receptor gamma (PPAR gamma) and to see whether LG100268, a retinoid X receptor (RXR) ligand, can inhibit proliferation of endometriotic cells alone or in synergy with ciglitazone, a PPAR gamma agonist. trichostatin A 30-44 peroxisome proliferator activated receptor gamma Homo sapiens 121-170 18571164-1 2009 OBJECTIVE: To examine whether trichostatin A (TSA), a histone deacetylase inhibitor (HDACI), can induce up-regulation of peroxisome proliferator-activating receptor gamma (PPAR gamma) and to see whether LG100268, a retinoid X receptor (RXR) ligand, can inhibit proliferation of endometriotic cells alone or in synergy with ciglitazone, a PPAR gamma agonist. trichostatin A 30-44 peroxisome proliferator activated receptor gamma Homo sapiens 172-182 18571164-1 2009 OBJECTIVE: To examine whether trichostatin A (TSA), a histone deacetylase inhibitor (HDACI), can induce up-regulation of peroxisome proliferator-activating receptor gamma (PPAR gamma) and to see whether LG100268, a retinoid X receptor (RXR) ligand, can inhibit proliferation of endometriotic cells alone or in synergy with ciglitazone, a PPAR gamma agonist. trichostatin A 30-44 peroxisome proliferator activated receptor gamma Homo sapiens 338-348 18571164-1 2009 OBJECTIVE: To examine whether trichostatin A (TSA), a histone deacetylase inhibitor (HDACI), can induce up-regulation of peroxisome proliferator-activating receptor gamma (PPAR gamma) and to see whether LG100268, a retinoid X receptor (RXR) ligand, can inhibit proliferation of endometriotic cells alone or in synergy with ciglitazone, a PPAR gamma agonist. trichostatin A 46-49 peroxisome proliferator activated receptor gamma Homo sapiens 121-170 18571164-1 2009 OBJECTIVE: To examine whether trichostatin A (TSA), a histone deacetylase inhibitor (HDACI), can induce up-regulation of peroxisome proliferator-activating receptor gamma (PPAR gamma) and to see whether LG100268, a retinoid X receptor (RXR) ligand, can inhibit proliferation of endometriotic cells alone or in synergy with ciglitazone, a PPAR gamma agonist. trichostatin A 46-49 peroxisome proliferator activated receptor gamma Homo sapiens 172-182 18571164-1 2009 OBJECTIVE: To examine whether trichostatin A (TSA), a histone deacetylase inhibitor (HDACI), can induce up-regulation of peroxisome proliferator-activating receptor gamma (PPAR gamma) and to see whether LG100268, a retinoid X receptor (RXR) ligand, can inhibit proliferation of endometriotic cells alone or in synergy with ciglitazone, a PPAR gamma agonist. trichostatin A 46-49 peroxisome proliferator activated receptor gamma Homo sapiens 338-348 18571164-2 2009 DESIGN: One endometrial stromal cell line and two endometriotic cell lines used as a model system: Western blot analysis to determine whether TSA can up-regulate PPAR gamma expression, and MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) proliferation assay to see whether ciglitazone and LG100268 have any antiproliferative effects individually or jointly. trichostatin A 142-145 peroxisome proliferator activated receptor gamma Homo sapiens 162-172 18571164-7 2009 RESULT(S): The TSA treatment resulted in up-regulation of PPAR gamma expression in all cell lines in a dose-dependent fashion. trichostatin A 15-18 peroxisome proliferator activated receptor gamma Homo sapiens 58-68 14985358-6 2004 VPA or TSA treatment reduced mRNA and protein levels of PPARgamma and SREBP1a. trichostatin A 7-10 peroxisome proliferator activated receptor gamma Homo sapiens 56-65