PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19961954-7	2010	Acetylation of S6K1 and 2 is increased upon the inhibition of class I/II histone deacetylases (HDACs) by trichostatin-A, while the enhancement of S6K1 acetylation by nicotinamide suggests the additional involvement of sirtuin deacetylases in S6K deacetylation.	trichostatin A	105-119	ribosomal protein S6 kinase B1	Homo sapiens	15-25	
28489607-6	2017	Further, TSA induced 5" AMP-activated protein kinase (p-AMPK) (T172) and inhibited mammalian target of rapamycin complex 1 (mTORC1) activity as estimated by phosphorylated ribosomal protein S6 kinase beta-1 (p-p70S6K) levels, thereby suggesting that TSA-mediated AMPK activation and inhibition of mTORC1 pathway might be associated with autophagy induction.	trichostatin A	9-12	ribosomal protein S6 kinase B1	Homo sapiens	172-206	
28489607-6	2017	Further, TSA induced 5" AMP-activated protein kinase (p-AMPK) (T172) and inhibited mammalian target of rapamycin complex 1 (mTORC1) activity as estimated by phosphorylated ribosomal protein S6 kinase beta-1 (p-p70S6K) levels, thereby suggesting that TSA-mediated AMPK activation and inhibition of mTORC1 pathway might be associated with autophagy induction.	trichostatin A	9-12	ribosomal protein S6 kinase B1	Homo sapiens	210-216	
24030871-7	2014	RAPA markedly inhibited cell proliferation, induced G1 cell cycle arrest, and reduced phosphorylation of p70 S6 protein kinase (p70S6K) and 4E-BP1 in GC cells, particularly when used in combination with LY294002 or TSA.	trichostatin A	215-218	ribosomal protein S6 kinase B1	Homo sapiens	105-126	
19961954-7	2010	Acetylation of S6K1 and 2 is increased upon the inhibition of class I/II histone deacetylases (HDACs) by trichostatin-A, while the enhancement of S6K1 acetylation by nicotinamide suggests the additional involvement of sirtuin deacetylases in S6K deacetylation.	trichostatin A	105-119	ribosomal protein S6 kinase B1	Homo sapiens	15-19