PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20816821-4 2010 A more direct action of FPI on membrane homeostasis was evidenced by a reduction in calcium-independent phospholipase A2 (iPLA2) important for metabolism of membrane phospholipids such as DHA, and an increase in the fatty acid transport protein (FATP) involved in translocation of long-chain fatty acids across the membrane. Phospholipids 166-179 patatin like phospholipase domain containing 2 Homo sapiens 84-120 32788291-6 2021 The mechanism involves the activation of a calcium-independent phospholipase A2 (iPLA2zeta) that releases the incorporated DHA from phospholipids and enhances the synthesis of docosanoids neuroprotectin D1 (NPD1) and a new resolvin stereoisomer RvD6i. Phospholipids 132-145 patatin like phospholipase domain containing 2 Homo sapiens 43-79 32788291-6 2021 The mechanism involves the activation of a calcium-independent phospholipase A2 (iPLA2zeta) that releases the incorporated DHA from phospholipids and enhances the synthesis of docosanoids neuroprotectin D1 (NPD1) and a new resolvin stereoisomer RvD6i. Phospholipids 132-145 patatin like phospholipase domain containing 2 Homo sapiens 81-90 31154555-1 2019 PURPOSE: The ubiquitous calcium-independent phospholipase A2 enzyme (iPLA2) is inhibited by calmodulin binding and known to be responsible for phospholipid remodeling housekeeping functions including granule exocytosis-associated membrane fusion in normal human neutrophils. Phospholipids 143-155 patatin like phospholipase domain containing 2 Homo sapiens 24-60 29457907-4 2018 We observed that loss of ATGL led to triacylglycerol accumulation in lipid droplets and higher levels of cellular phospholipid and bioactive lipid species (lyso- and ether-phospholipids). Phospholipids 114-126 patatin like phospholipase domain containing 2 Homo sapiens 25-29 29342349-5 2018 Molecular dynamics simulations revealed the optimal phospholipid binding mode leading to a detailed understanding of the preference of cytosolic phospholipase A2 for cleavage of proinflammatory arachidonic acid, calcium-independent phospholipase A2, which is involved in membrane remodeling for cleavage of linoleic acid and for antibacterial secreted phospholipase A2 favoring linoleic acid, saturated fatty acids, and phosphatidylglycerol. Phospholipids 52-64 patatin like phospholipase domain containing 2 Homo sapiens 212-248 28368219-3 2017 OBJECTIVE: To examine the impact of ATGL on AA-release from cellular phospholipids (PL) and on prostacyclin secretion in human aortic endothelial cells (HAEC). Phospholipids 69-82 patatin like phospholipase domain containing 2 Homo sapiens 36-40 21908733-9 2011 Our data show that the concurrent inhibition of iPLA(2) and prostanoid production causes an accumulation of free intracellular arachidonic acid by disrupting the phospholipid deacylation-reacylation cycle. Phospholipids 162-174 patatin like phospholipase domain containing 2 Homo sapiens 48-55 20816821-4 2010 A more direct action of FPI on membrane homeostasis was evidenced by a reduction in calcium-independent phospholipase A2 (iPLA2) important for metabolism of membrane phospholipids such as DHA, and an increase in the fatty acid transport protein (FATP) involved in translocation of long-chain fatty acids across the membrane. Phospholipids 166-179 patatin like phospholipase domain containing 2 Homo sapiens 122-127 19059366-3 2009 We hypothesize that these proteases activate calcium-independent phospholipase A2 (iPLA2), in HMVEC-L, leading to the production of membrane phospholipids-derived inflammatory mediators. Phospholipids 141-154 patatin like phospholipase domain containing 2 Homo sapiens 45-81 19059366-3 2009 We hypothesize that these proteases activate calcium-independent phospholipase A2 (iPLA2), in HMVEC-L, leading to the production of membrane phospholipids-derived inflammatory mediators. Phospholipids 141-154 patatin like phospholipase domain containing 2 Homo sapiens 83-88 19059366-9 2009 Collectively, these data support our hypothesis that iPLA2 activity is responsible for membrane phospholipid hydrolysis in response to tryptase or thrombin stimulation in HMVEC-L. Phospholipids 96-108 patatin like phospholipase domain containing 2 Homo sapiens 53-58 12372769-6 2002 Thus stimulation of PAR-1 or PAR-2 on HUR leads to iPLA(2)-catalyzed phospholipid hydrolysis, resulting in the production of metabolites that may mediate inflammation or provide cytoprotection to the bladder. Phospholipids 69-81 patatin like phospholipase domain containing 2 Homo sapiens 51-58 16943248-1 2007 Thrombin stimulation of human coronary artery endothelial cells (HCAEC) results in activation of a membrane-associated, calcium-independent phospholipase A(2) (iPLA(2)) that selectively hydrolyzes membrane plasmalogen phospholipids. Phospholipids 218-231 patatin like phospholipase domain containing 2 Homo sapiens 120-158 16943248-1 2007 Thrombin stimulation of human coronary artery endothelial cells (HCAEC) results in activation of a membrane-associated, calcium-independent phospholipase A(2) (iPLA(2)) that selectively hydrolyzes membrane plasmalogen phospholipids. Phospholipids 218-231 patatin like phospholipase domain containing 2 Homo sapiens 160-167 16943248-8 2007 Pretreatment with bromoenol lactone to inhibit iPLA(2) blocked membrane phospholipid hydrolysis and production of membrane phospholipid-derived metabolites. Phospholipids 72-84 patatin like phospholipase domain containing 2 Homo sapiens 47-54 16943248-8 2007 Pretreatment with bromoenol lactone to inhibit iPLA(2) blocked membrane phospholipid hydrolysis and production of membrane phospholipid-derived metabolites. Phospholipids 123-135 patatin like phospholipase domain containing 2 Homo sapiens 47-54 17266551-6 2007 iPLA(2) plays a critical role in the synthesis of membrane phospholipid-derived inflammatory mediators such as arachidonic acid, platelet activating factor (PAF), and prostaglandins, all demonstrated to be central in both the initiation and propagation of the inflammatory response. Phospholipids 59-71 patatin like phospholipase domain containing 2 Homo sapiens 0-7 16882668-1 2006 Calcium-independent phospholipase A(2) (iPLA(2)) plays a pivotal role in phospholipid remodeling and many other biological processes, including inflammation and cancer development. Phospholipids 73-85 patatin like phospholipase domain containing 2 Homo sapiens 0-38 16882668-1 2006 Calcium-independent phospholipase A(2) (iPLA(2)) plays a pivotal role in phospholipid remodeling and many other biological processes, including inflammation and cancer development. Phospholipids 73-85 patatin like phospholipase domain containing 2 Homo sapiens 40-47 15252038-6 2004 Compared with control cells, the iPLA2 -overexpressing U937 cells showed elevated responses to hydrogen peroxide with regard to both arachidonic acid mobilization and incorporation of the fatty acid into phospholipids, thus providing additional evidence for the key role that iPLA2 plays in these events. Phospholipids 204-217 patatin like phospholipase domain containing 2 Homo sapiens 33-38 15252038-10 2004 These results indicate that, although iPLA2-mediated phospholipid hydrolysis occurs during apoptosis, iPLA2 may actually be dispensable for the apoptotic process to occur. Phospholipids 53-65 patatin like phospholipase domain containing 2 Homo sapiens 38-43 17188740-1 2007 INTRODUCTION: Thrombin or tryptase cleavage of protease-activated receptors (PAR) on human coronary artery endothelial cells (HCAEC) results in activation of a membrane-associated, calcium-independent phospholipase A2 (iPLA2) that selectively hydrolyzes plasmalogen phospholipids. Phospholipids 266-279 patatin like phospholipase domain containing 2 Homo sapiens 181-217 17188740-1 2007 INTRODUCTION: Thrombin or tryptase cleavage of protease-activated receptors (PAR) on human coronary artery endothelial cells (HCAEC) results in activation of a membrane-associated, calcium-independent phospholipase A2 (iPLA2) that selectively hydrolyzes plasmalogen phospholipids. Phospholipids 266-279 patatin like phospholipase domain containing 2 Homo sapiens 219-224 17130640-10 2006 Glucose-stimulated release of arachidonic acid from phospholipids by calcium-independent phospholipase A2 and/or from TG/FFA cycling may also be involved. Phospholipids 52-65 patatin like phospholipase domain containing 2 Homo sapiens 69-105 15937147-3 2005 We have previously shown that tryptase increases human bladder microvascular endothelial cell (HBMEC) calcium-independent phospholipase A(2) (iPLA(2)) activity, resulting in the production of multiple biologically active phospholipid metabolites, including platelet-activating factor (PAF), that can mediate inflammation. Phospholipids 221-233 patatin like phospholipase domain containing 2 Homo sapiens 142-149 15252038-1 2004 Group VIA calcium-independent phospholipase A2 (iPLA2) has been shown to play a major role in regulating basal phospholipid deacylation reactions in certain cell types. Phospholipids 111-123 patatin like phospholipase domain containing 2 Homo sapiens 10-46 15252038-1 2004 Group VIA calcium-independent phospholipase A2 (iPLA2) has been shown to play a major role in regulating basal phospholipid deacylation reactions in certain cell types. Phospholipids 111-123 patatin like phospholipase domain containing 2 Homo sapiens 48-53 15305016-3 2004 The catalytic action of iPLA2 is known to be responsible for phospholipid remodeling as a housekeeping function. Phospholipids 61-73 patatin like phospholipase domain containing 2 Homo sapiens 24-29 10092620-10 1999 GPC formation was blocked by bromoenol lactone, implicating the calcium-independent phospholipase A2 as a key participant in the response to excess phospholipid. Phospholipids 148-160 patatin like phospholipase domain containing 2 Homo sapiens 64-100 7667324-0 1995 Inhibition of calcium-independent phospholipase A2 prevents arachidonic acid incorporation and phospholipid remodeling in P388D1 macrophages. Phospholipids 95-107 patatin like phospholipase domain containing 2 Homo sapiens 14-50