PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21177434-2	2011	Herein, four 5-LOX-derived lipids comprising 5-hydroxyeicosatetraenoic acid (HETE) attached to phospholipids (PLs), either phosphatidylethanolamine (PE) or phosphatidylcholine (18:0p/5-HETE-PE, 18:1p/5-HETE-PE, 16:0p/5-HETE-PE, and 16:0a/5-HETE-PC), were identified in primary human neutrophils.	Phospholipids	95-108	arachidonate 5-lipoxygenase	Homo sapiens	13-18	
21177434-2	2011	Herein, four 5-LOX-derived lipids comprising 5-hydroxyeicosatetraenoic acid (HETE) attached to phospholipids (PLs), either phosphatidylethanolamine (PE) or phosphatidylcholine (18:0p/5-HETE-PE, 18:1p/5-HETE-PE, 16:0p/5-HETE-PE, and 16:0a/5-HETE-PC), were identified in primary human neutrophils.	Phospholipids	110-113	arachidonate 5-lipoxygenase	Homo sapiens	13-18	
15923196-1	2005	5-Lipoxygenase (5-LO) catalysis is positively regulated by Ca2+ ions and phospholipids that both act via the N-terminal C2-like domain of 5-LO.	Phospholipids	73-86	arachidonate 5-lipoxygenase	Homo sapiens	0-14	
15572846-8	2004	Since the 5-lipoxygenase pathway is abundantly expressed in atherosclerotic lesions, and 12/15-lipoxygenase is able to oxygenate polyunsaturated fatty acid esterified in the membranous phospholipids, 5-lipoxygenase or 12/15-lipoxygenase inhibitors may prevent progression of atherosclerosis.	Phospholipids	185-198	arachidonate 5-lipoxygenase	Homo sapiens	10-24	
15572846-8	2004	Since the 5-lipoxygenase pathway is abundantly expressed in atherosclerotic lesions, and 12/15-lipoxygenase is able to oxygenate polyunsaturated fatty acid esterified in the membranous phospholipids, 5-lipoxygenase or 12/15-lipoxygenase inhibitors may prevent progression of atherosclerosis.	Phospholipids	185-198	arachidonate 5-lipoxygenase	Homo sapiens	93-107	
15366660-4	2003	Leukotrienes are synthesized through the 5-lipoxygenase pathway from the arachidonic acid which is released from the phospholipids forming the membrane of activated cells.	Phospholipids	117-130	arachidonate 5-lipoxygenase	Homo sapiens	41-55	
9620944-1	1998	Cytosolic phospholipase A2 translocates from the cytoplasm to selectively hydrolyze nuclear envelope phospholipids, releasing free arachidonate. 5-Lipoxygenase-activating protein, an arachidonate transfer protein, then binds arachidonate and presents it to 5-lipoxygenase (5-LO), which catalyzes a two-step reaction to produce leukotriene A4. In resting human and rat peripheral blood neutrophils, 5-LO is localized to the cytoplasm; in rat basophilic leukemia cells and human alveolar macrophages, however, it is found predominantly in the nucleus.	Phospholipids	102-115	arachidonate 5-lipoxygenase	Homo sapiens	146-160	
7577949-5	1995	Photoaffinity labeling of 5-lipoxygenase by L-708,714 was dependent on the presence of both Ca2+ ions and phospholipids and was independent of ATP.	Phospholipids	106-119	arachidonate 5-lipoxygenase	Homo sapiens	26-40	
7900879-1	1995	5-Lipoxygenase (5-LO) converts arachidonic acid, released from membrane phospholipids upon external stimulation, to leukotriene C4 (LTC4), which induces various kinds of cellular and molecular responses.	Phospholipids	72-85	arachidonate 5-lipoxygenase	Homo sapiens	0-14	
8395245-2	1993	The enzymatic activity of purified human 5-lipoxygenase was dependent on the ratio of arachidonic acid to phospholipids rather than on the bulk arachidonic acid concentration, suggesting that the concentration of substrate at the lipid-water interface is important for the rate of the 5-LO reaction.	Phospholipids	106-119	arachidonate 5-lipoxygenase	Homo sapiens	41-55	
8395245-6	1993	The data are consistent with the catalysis of 5-LO occurring at the surface of phospholipid vesicles with the 5-HPETE product being re-utilized by the LTA4 synthase reaction of 5-lipoxygenase under conditions of limiting arachidonic acid availability.	Phospholipids	79-91	arachidonate 5-lipoxygenase	Homo sapiens	177-191	
6088299-9	1984	In addition, modulation of phospholipids could serve to activate a protein kinase C. Finally, phospholipids can serve as a source for arachidonic acid, which is metabolized by a 5-lipoxygenase pathway in the neutrophil.	Phospholipids	27-40	arachidonate 5-lipoxygenase	Homo sapiens	178-192	
6088299-9	1984	In addition, modulation of phospholipids could serve to activate a protein kinase C. Finally, phospholipids can serve as a source for arachidonic acid, which is metabolized by a 5-lipoxygenase pathway in the neutrophil.	Phospholipids	94-107	arachidonate 5-lipoxygenase	Homo sapiens	178-192