PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9454819-4 1998 Prophylactic administration of N-iminoethyl-L-lysine (L-NIL) completely abolished iNOS activity (plasma NOx elevation) and effectively reduced both the swelling and radiographic changes in the joint tissues of the noninjected paw measured on day 21. nicotine 1-N-oxide 104-107 nitric oxide synthase 2 Rattus norvegicus 82-86 9565258-14 1998 This sustained increase in NOx levels in this model correlated with the observable signs of systemic infection and may relate to enhanced iNOS activity. nicotine 1-N-oxide 27-30 nitric oxide synthase 2 Rattus norvegicus 138-142 15869603-1 2005 We examined the role of nitric oxide (NO) produced by an inducible isoform of NO synthase (iNOS) using N[6]-(iminoethyl)-lysine (L-NIL), a selective iNOS inhibitor, in the rat model of lipopolysaccharide (LPS)-induced disseminated intravascular coagulation (DIC) and investigated changes in organ function, plasma levels of NOX (metabolites of NO) and endothelin. nicotine 1-N-oxide 324-327 nitric oxide synthase 2 Rattus norvegicus 91-95 7509342-1 1994 By measurements of NO2-/NO3- (NOx) production and Northern blot analysis, we studied the effects of a membrane-permeable cAMP derivative, 8-bromo-cAMP, on the expression of inducible nitric oxide synthase (iNOS) gene and the synthesis of NOx in cultured rat vascular smooth muscle cells (VSMCs). nicotine 1-N-oxide 30-33 nitric oxide synthase 2 Rattus norvegicus 173-204 7509342-1 1994 By measurements of NO2-/NO3- (NOx) production and Northern blot analysis, we studied the effects of a membrane-permeable cAMP derivative, 8-bromo-cAMP, on the expression of inducible nitric oxide synthase (iNOS) gene and the synthesis of NOx in cultured rat vascular smooth muscle cells (VSMCs). nicotine 1-N-oxide 238-241 nitric oxide synthase 2 Rattus norvegicus 173-204 24512212-7 2014 Inhibition of iNOS via administration of 1400W ameliorated renal injury and decreased tissue lipid peroxidation (malondialdehyde), superoxide dismutase, glutathione peroxidase and nitrite/nitrate levels (NOx). nicotine 1-N-oxide 204-207 nitric oxide synthase 2 Rattus norvegicus 14-18 24441717-5 2014 Plasma nitrate and nitrite (NOx) were markedly high with upregulation of inducible nitric oxide synthase (iNOS) expression, but dowregulation of endothelial nitric oxide synthase (eNOS) expression (p<0.05). nicotine 1-N-oxide 28-31 nitric oxide synthase 2 Rattus norvegicus 73-104 24441717-5 2014 Plasma nitrate and nitrite (NOx) were markedly high with upregulation of inducible nitric oxide synthase (iNOS) expression, but dowregulation of endothelial nitric oxide synthase (eNOS) expression (p<0.05). nicotine 1-N-oxide 28-31 nitric oxide synthase 2 Rattus norvegicus 106-110 17711694-7 2007 NOx production by 10(-7) mol/L and 10(-6) mol/L ALD increased by 50.0% and 58.7% respectively (P < 0.01) and iNOS activity was also significantly increased (P < 0.01) in ALD + RU486 group than that in ALD group. nicotine 1-N-oxide 0-3 nitric oxide synthase 2 Rattus norvegicus 112-116 12433208-4 2002 In brain, NOx was increased by about 40% vs. normal and it was significantly inhibited by aminoguanidine, selective iNOS inhibitor. nicotine 1-N-oxide 10-13 nitric oxide synthase 2 Rattus norvegicus 116-120 14555681-9 2004 Aminoguanidine, an inhibitor of iNOS, significantly attenuated the LPS-induced NOx production and contractile dysfunction. nicotine 1-N-oxide 79-82 nitric oxide synthase 2 Rattus norvegicus 32-36 12527339-6 2003 resulted in a significant reduction of the expression of iNOS protein in rat lung tissue and in the plasma nitrite/nitrate (NOx) level. nicotine 1-N-oxide 124-127 nitric oxide synthase 2 Rattus norvegicus 57-61 12433208-5 2002 This result showed that NOx concentration was increased by iNOS. nicotine 1-N-oxide 24-27 nitric oxide synthase 2 Rattus norvegicus 59-63 12433208-17 2002 In summary, ischemic model caused an increase of NOx concentration, suggesting that this may be produced via iNOS, which is calcium independent in brain. nicotine 1-N-oxide 49-52 nitric oxide synthase 2 Rattus norvegicus 109-113 12231464-2 2002 The purpose of this study is to examine time-dependent changes of nitrite and nitrate (NOx) concentration in the circulation, and peroxynitrite formation as well as the expression of inducible nitric oxide synthase (iNOS) in the penumbra of rat brains during transient middle cerebral artery occlusion (MCAO) of Wistar rat for 2 h and reperfusion for 4-70 h. NOx concentration in the circulation was continuously monitored at the right jugular vein by microdialysis. nicotine 1-N-oxide 359-362 nitric oxide synthase 2 Rattus norvegicus 216-220 12231464-7 2002 These results suggest that a marked increase of NOx level in the circulation might reflect the expression of iNOS, while neuronal NOS may contribute to peroxynitrite formation in the cortex observed at an earlier phase of reperfusion. nicotine 1-N-oxide 48-51 nitric oxide synthase 2 Rattus norvegicus 109-113