PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2539468-1 1989 Because atrial natriuretic factor (Atriopeptin II, ANF) exerts potent effects on Na+ transport in a number of tissues, we examined its influence on 22Na+-uptake in isolated rabbit aorta segments and the possible relation to ANF-induced vasorelaxation. Sodium-22 148-153 natriuretic peptides A Oryctolagus cuniculus 51-54 2539468-2 1989 ANF increased 22Na+-uptake by 44% with an EC50 of 12 nM whereas sodium nitroprusside was without effect. Sodium-22 14-19 natriuretic peptides A Oryctolagus cuniculus 0-3 2539468-7 1989 These results suggest that ANF activation of EIPA-sensitive 22Na+-uptake occurs before cGMP formation perhaps at the level of the ANF receptor itself. Sodium-22 60-65 natriuretic peptides A Oryctolagus cuniculus 27-30