PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8603747-6 1996 Second, the activation by diacylglycerol is not stereospecific, in marked contrast to the specificity for 1,2-diacyl-sn-glycerol in the activation of protein kinase C. Because circulating levels of insulin are below the Kd of the insulin receptor for insulin, the ability of diacylglycerol to modulate the affinity of the receptor for ligand suggests that increases in cellular levels of diacylglycerol directly sensitize the receptor to insulin. 1,2-diacyl-sn-glycerol 106-128 insulin receptor Homo sapiens 230-246