PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12149216-4 2002 In transcriptional coactivation assays, oxidized EPA potently activated the peroxisome proliferator-activated receptor alpha (PPAR alpha), a member of the nuclear receptor family. Eicosapentaenoic Acid 49-52 peroxisome proliferator activated receptor alpha Mus musculus 126-136 17765904-10 2008 The anti-inflammatory effects of EPA were abrogated when the expression of peroxisome proliferator-activated receptor alpha (PPARalpha) was suppressed. Eicosapentaenoic Acid 33-36 peroxisome proliferator activated receptor alpha Mus musculus 75-123 17765904-10 2008 The anti-inflammatory effects of EPA were abrogated when the expression of peroxisome proliferator-activated receptor alpha (PPARalpha) was suppressed. Eicosapentaenoic Acid 33-36 peroxisome proliferator activated receptor alpha Mus musculus 125-134 19162361-8 2009 RESULTS: EPA-ameliorated hepatic steatosis in Pten-deficient mice was based on decreased expression of AMPKalpha1-mediated SREBP-1c and increased PPARalpha expression. Eicosapentaenoic Acid 9-12 peroxisome proliferator activated receptor alpha Mus musculus 146-155 12149216-6 2002 This occurred via a PPAR alpha-dependent mechanism because oxidized EPA had no such effect in LPS-treated PPAR alpha-deficient mice. Eicosapentaenoic Acid 68-71 peroxisome proliferator activated receptor alpha Mus musculus 20-30 12149216-7 2002 Therefore, the beneficial effects of omega-3 fatty acids may be explained by a PPAR alpha-mediated anti-inflammatory effect of oxidized EPA. Eicosapentaenoic Acid 136-139 peroxisome proliferator activated receptor alpha Mus musculus 79-89 10753628-6 2000 EPA is a ligand for peroxisome proliferator-activated receptors (PPARs) with the highest affinity to PPARalpha. Eicosapentaenoic Acid 0-3 peroxisome proliferator activated receptor alpha Mus musculus 101-110 26690553-12 2015 Fatty acid beta-oxidation related genes, on the other hand, such as peroxisome proliferator-activated receptor alpha (PPARalpha), carnitine palmitoyltransferase (CPT) and acyl-CoA oxidase 1 (ACOX1) were elevated in both WT and SKO groups on DHA/EPA diets. Eicosapentaenoic Acid 245-248 peroxisome proliferator activated receptor alpha Mus musculus 68-116 30871035-6 2019 With EPA, hepatic lipid metabolism was improved in HF-EPA mice, as indicated by decreased protein and messenger RNA (mRNA) levels of fatty acid synthase (FASN) and acetyl-CoA carboxylase (Acaca) gene, and increased mRNA levels for the peroxisome proliferator activated receptor-alpha (Pparalpha), and carnitine palmitoyltransferase (Cpt) 1a and 2 genes in the HF-EPA mice. Eicosapentaenoic Acid 5-8 peroxisome proliferator activated receptor alpha Mus musculus 235-283 30871035-6 2019 With EPA, hepatic lipid metabolism was improved in HF-EPA mice, as indicated by decreased protein and messenger RNA (mRNA) levels of fatty acid synthase (FASN) and acetyl-CoA carboxylase (Acaca) gene, and increased mRNA levels for the peroxisome proliferator activated receptor-alpha (Pparalpha), and carnitine palmitoyltransferase (Cpt) 1a and 2 genes in the HF-EPA mice. Eicosapentaenoic Acid 5-8 peroxisome proliferator activated receptor alpha Mus musculus 285-294 30261280-9 2018 Pathways related to thermogenesis such as peroxisome proliferator-activated receptor (PPAR) were upregulated by EPA while pathways associated with obesity and inflammation such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) were downregulated by EPA. Eicosapentaenoic Acid 112-115 peroxisome proliferator activated receptor alpha Mus musculus 42-84 30261280-9 2018 Pathways related to thermogenesis such as peroxisome proliferator-activated receptor (PPAR) were upregulated by EPA while pathways associated with obesity and inflammation such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) were downregulated by EPA. Eicosapentaenoic Acid 112-115 peroxisome proliferator activated receptor alpha Mus musculus 86-90 26690553-12 2015 Fatty acid beta-oxidation related genes, on the other hand, such as peroxisome proliferator-activated receptor alpha (PPARalpha), carnitine palmitoyltransferase (CPT) and acyl-CoA oxidase 1 (ACOX1) were elevated in both WT and SKO groups on DHA/EPA diets. Eicosapentaenoic Acid 245-248 peroxisome proliferator activated receptor alpha Mus musculus 118-127 20691165-2 2010 However, it remains unclear whether such action of EPA is actually caused by peroxisome proliferator-activated receptor alpha (PPARalpha) activation. Eicosapentaenoic Acid 51-54 peroxisome proliferator activated receptor alpha Mus musculus 77-125 20691165-2 2010 However, it remains unclear whether such action of EPA is actually caused by peroxisome proliferator-activated receptor alpha (PPARalpha) activation. Eicosapentaenoic Acid 51-54 peroxisome proliferator activated receptor alpha Mus musculus 127-136 22106967-4 2012 Both PUFA treatments showed anti-inflammatory activity; EPA appeared to act via the PPARalpha pathway, whereas AA appeared to increase energy metabolism and cytoskeletal organization and reduce cellular stress responses, possibly enabling a more robust response to inflammation. Eicosapentaenoic Acid 56-59 peroxisome proliferator activated receptor alpha Mus musculus 84-93 20691165-7 2010 Instead, EPA inhibited maturation of sterol-responsive element-binding protein (SREBP)-1 in the presence of PPARalpha through down-regulation of SREBP cleavage-activating protein and site-1 protease. Eicosapentaenoic Acid 9-12 peroxisome proliferator activated receptor alpha Mus musculus 108-117 20691165-8 2010 Additionally, EPA suppressed fatty acid uptake and promoted hydrolysis of intrahepatic triglycerides in a PPARalpha-independent manner. Eicosapentaenoic Acid 14-17 peroxisome proliferator activated receptor alpha Mus musculus 106-115 20691165-10 2010 Although fenofibrate induced NAPDH oxidase and acyl-coenzyme A oxidase and significantly increased hepatic lipid peroxides, EPA caused PPARalpha-dependent induction of superoxide dismutases, probably contributing to a decrease in the lipid peroxides. Eicosapentaenoic Acid 124-127 peroxisome proliferator activated receptor alpha Mus musculus 135-144