PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19663260-11 2009 It has also been observed in mice with orexin deficit produced by molecular genetics that they have a significantly low development of dependency on amphetamine, a relative compound of methylphenidate. Amphetamine 149-160 hypocretin Mus musculus 39-45 35101602-0 2022 Orexin deficiency affects sensorimotor gating and its amphetamine-induced impairment. Amphetamine 54-65 hypocretin Mus musculus 0-6 35101602-3 2022 Utilizing orexin-deficient mice, the present study tested the hypothesis that orexin is involved in two further mouse behavioral endophenotypes of neuropsychiatric disorders, i.e., sensorimotor gating and amphetamine sensitivity. Amphetamine 205-216 hypocretin Mus musculus 78-84 35101602-5 2022 Amphetamine treatment impaired prepulse inhibition in wildtype and heterozygous orexin-deficient mice, but had no effects in homozygous orexin-deficient mice. Amphetamine 0-11 hypocretin Mus musculus 80-86 35101602-7 2022 These data indicate that the orexin system modulates prepulse inhibition and is involved in mediating amphetamine"s effect on prepulse inhibition. Amphetamine 102-113 hypocretin Mus musculus 29-35 30465812-9 2019 Finally, in vivo microdialysis experiments showed that amphetamine potentiated orexin A-induced dopamine and glutamate release in the ventral tegmental area (VTA). Amphetamine 55-66 hypocretin Mus musculus 79-87