PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10362602-4	1999	Both superoxide (generated by xanthine oxidase plus hypoxanthine) and hydrogen peroxide were potent inducers of PAI-1, and hydroxyl radical scavengers completely abolished the TNF-alpha induction of PAI-1.	Hypoxanthine	52-64	tumor necrosis factor	Homo sapiens	176-185	
21605007-4	2011	RESULTS: At baseline, the purines AMP and hypoxanthine correlated with multiple inflammatory markers including neutrophil counts and the cytokines interleukin (IL)-6, IL-8, tumor necrosis factor alpha (TNF-alpha), and IL-1beta (r ranged from 0.41 to 0.66, all P < 0.05).	Hypoxanthine	42-54	tumor necrosis factor	Homo sapiens	202-211	
18369465-7	2008	Degradation of Plasmodium-derived hypoxanthine/xanthine results in the formation of uric acid, which triggers the secretion of TNF.	Hypoxanthine	34-46	tumor necrosis factor	Homo sapiens	127-130	
33370225-10	2022	RESULTS: In the presence of xanthine oxidase, hypoxanthine, alone and in combination with RBC supernatants, caused increases of TNF-alpha- and IL-8-positive cells after 5 hours of treatment.	Hypoxanthine	46-58	tumor necrosis factor	Homo sapiens	128-137