PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21396949-6 2011 Furthermore, co-treatment of cells with hypoxanthine plus 3-HK or MPA, which caused a reduction of about 60% in the intracellular GTP levels, led to apoptosis and activation of mitochondrial pathways through inverse regulation of Bcl-2/Bax expression and activation of caspase-3. Hypoxanthine 40-52 BCL2 apoptosis regulator Homo sapiens 230-235 14712481-5 2004 These effects, associated with an up-regulation of p53, p21 and bax, a shuttling of p53 protein into the nucleus and a down-regulation of bcl-2, survivin and p27 protein, were reversed by the simultaneous addition of guanine or guanosine and were more evident using nondialysed serum containing hypoxanthine. Hypoxanthine 295-307 BCL2 apoptosis regulator Homo sapiens 138-143