PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20854262-2 2010 The chlorogenic acid derivative S4048 is a pharmacological inhibitor of the glucose 6-phosphate transporter, which is part of glucose-6-phosphatase, and allows for mechanistic studies concerning metabolic defects in GSD-1. Chlorogenic Acid 4-20 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 216-221 25959621-0 2015 Instant coffee extract with high chlorogenic acids content inhibits hepatic G-6-Pase in vitro, but does not reduce the glycaemia. Chlorogenic Acid 33-50 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 76-84 25959621-4 2015 Instant coffee extract with high chlorogenic acids content (37.8%) inhibited (p < 0.05) the G-6-Pase activity of the hepatocyte microsomal fraction in a dose-dependent way (up to 53), but IV administration of this extract did not change the glycaemia (p > 0.05). Chlorogenic Acid 33-50 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 95-103 25959621-6 2015 It was concluded that instant coffee extract with high content of chlorogenic acids inhibited hepatic G-6-Pase in vitro, but failed to reduce the glycaemia probably because the coffee chlorogenic acids did not reach enough levels within the hepatocytes to inhibit the G-6-Pase and reduce the liver glucose output. Chlorogenic Acid 66-83 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 102-110 20302380-0 2010 Contribution of chlorogenic acids to the inhibition of human hepatic glucose-6-phosphatase activity in vitro by Svetol, a standardized decaffeinated green coffee extract. Chlorogenic Acid 16-33 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 69-90 18267120-3 2008 Chlorogenic acid and (-)-epigallocatechin-3-gallate, two diet-derived inhibitors of G6PT and of MT1-MMP, respectively, reduced S1P-mediated Ca(2+) mobilization. Chlorogenic Acid 0-16 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 84-88 11359348-6 2001 In fact, certain new drugs being developed for diabetes therapy - chlorogenic acid derivatives and "compound A" - are potent inhibitors of glucose-6-phosphatase, and both AICA riboside and 2,5-anhydro-D-mannitol have potential as clinical inhibitors of fructosediphosphatase. Chlorogenic Acid 66-82 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 139-160