PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33142463-6 2020 And the level of caspase 3 protein was significantly upregulated with treating chlorogenic acid, beta-D-Glucan, astragalus polysacharin, astragalus flavone, curcumin, CpG-DNA-2, chicken IgG, LPS, and poly(I:C). Chlorogenic Acid 79-95 caspase 3 Homo sapiens 17-26 23160680-7 2012 Furthermore, the activity of caspase-3 was evaluated and results indicated that chlorogenic acid promoted caspase-3 activity in U937 cells. Chlorogenic Acid 80-96 caspase 3 Homo sapiens 29-38 28875417-5 2018 Polymerase chain reaction (PCR) showed that treatment of cells with chlorogenic acid reduced the expression of BCL2 but increased that of both BAX and CASP3. Chlorogenic Acid 68-84 caspase 3 Homo sapiens 151-156 23160680-7 2012 Furthermore, the activity of caspase-3 was evaluated and results indicated that chlorogenic acid promoted caspase-3 activity in U937 cells. Chlorogenic Acid 80-96 caspase 3 Homo sapiens 106-115 23160680-8 2012 Results from western blot analysis showed that chlorogenic acid promoted expression of caspase-3, -7, -8 and -9 in U937 cells. Chlorogenic Acid 47-63 caspase 3 Homo sapiens 87-111 23160680-9 2012 Taken together, these results suggest that chlorogenic acid may induce apoptosis by reducing the levels of DeltaPsim and by increasing the activation of caspase-3 pathways in human leukemia U937 cells in vitro. Chlorogenic Acid 43-59 caspase 3 Homo sapiens 153-162