PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
14990704-2	2004	Roscovitine (Rosco) is a purine derivative that inhibits cyclin-dependent kinase 1 (cdk1), cdk2, cdk5, cdk7, and cdk9, which are key regulators of the cell cycle and transcription.	purine	25-31	cyclin dependent kinase 1	Homo sapiens	57-82	
14990704-2	2004	Roscovitine (Rosco) is a purine derivative that inhibits cyclin-dependent kinase 1 (cdk1), cdk2, cdk5, cdk7, and cdk9, which are key regulators of the cell cycle and transcription.	purine	25-31	cyclin dependent kinase 1	Homo sapiens	84-88	
25541464-0	2015	Yeast as a model system to screen purine derivatives against human CDK1 and CDK2 kinases.	purine	34-40	cyclin dependent kinase 1	Homo sapiens	67-71	
11417113-8	2001	It is now reported that CDK1 inhibitory activities of purine analogs correlate with the physiochemical parameters of purine analogs.	purine	54-60	cyclin dependent kinase 1	Homo sapiens	24-28	
11417113-8	2001	It is now reported that CDK1 inhibitory activities of purine analogs correlate with the physiochemical parameters of purine analogs.	purine	117-123	cyclin dependent kinase 1	Homo sapiens	24-28	
10683156-7	2000	Addition of deoxyribonucleosides shows that rapid S-phase condensation is suppressed by a novel checkpoint mechanism: purine (but not pyrimidine) deoxyribonucleosides, like reverse transformation, suppress cyclin B/p34(cdc2) activation by caffeine, but not cyclin B accumulation.	purine	118-124	cyclin dependent kinase 1	Homo sapiens	219-223	
9553063-13	1998	SBCRK and histidine-tagged CRK3 activities were inhibited by the purine analogue olomoucine with an IC50 of 28 and 42 microM, respectively, 5-6-fold higher than human p34(cdc2)/cyclinB.	purine	65-71	cyclin dependent kinase 1	Homo sapiens	171-175	
26207228-2	2015	It is a broad-range purine inhibitor, which inhibits CDK1, CDK2, CDK5 and CDK7, but is a poor inhibitor for CDK4 and CDK6.	purine	20-26	cyclin dependent kinase 1	Homo sapiens	53-57	
12392733-1	2002	Based on our previous experiences with synthesis of purines, novel 2,6,9-trisubstituted purine derivatives were prepared and assayed for the ability to inhibit CDK1/cyclin B kinase.	purine	52-58	cyclin dependent kinase 1	Homo sapiens	160-164	
25541464-4	2015	In the present study, taking advantage of the fact that deletion of the yeast CDC28 gene is functionally complemented by human CDK1 or CDK2, we set up an in vivo screen system to evaluate the inhibitory potency of purine derivatives against these two human Cdks.	purine	214-220	cyclin dependent kinase 1	Homo sapiens	127-131	
15308730-4	2004	In contrast, roscovitine and other purine PCIs inhibit with high potency only CDK1, CDK2, CDK5, and CDK7, and they specifically inhibit the expression of viral but not cellular genes.	purine	35-41	cyclin dependent kinase 1	Homo sapiens	78-82	
24304238-1	2014	Evaluation of the effects of purine C-8 substitution within a series of CDK1/2-selective O(6)-cyclohexylmethylguanine derivatives revealed that potency decreases initially with increasing size of the alkyl substituent.	purine	29-35	cyclin dependent kinase 1	Homo sapiens	72-76