PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28145544-7 2017 (ii) Both IA and IB convert to a common component II (apparent transition pKa ~7.8 for IA and ~6.5 for IB, respectively) featuring a tridentate ligand consisting of the N-terminal amine, the Asp1-Ala2 amide and the Ala2-Pro3 carbonyl; this stereochemistry is stabilized by two five-membered chelate rings. Amines 180-185 beta-secretase 2 Homo sapiens 191-195 30239184-3 2018 Our advanced EPR spectroscopic results revealed that a chemical regulator (1) for CuII-Abeta1-16 disrupted the coordination environment of CuII in Abeta, resulting in the detachment of the primary amine at the N-terminal and a carbonyl group between Asp1 and Ala2 from the CuII center and the subsequent formation of a ternary complex, chemical regulator-CuII-Abeta1-16. Amines 197-202 beta-secretase 2 Homo sapiens 250-254