PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17636046-2	2007	UGT1A3 glucuronidates the planar phenols 1-naphthol (1-NP) and 4-methylumbelliferone (4-MU), whereas UGT1A4 converts the tertiary amines lamotrigine (LTG) and trifluoperazine (TFP) to quaternary ammonium glucuronides.	Amines	130-136	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	0-6	
17636046-11	2007	Thus, residues 36 and 40 of UGT1A3 and UGT1A4 are pivotal for the respective selectivities of these enzymes toward planar phenols and tertiary amines, although other regions of the proteins influence binding affinity and/or turnover.	Amines	143-149	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	28-34	
9616184-0	1998	Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3.	Amines	19-25	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	77-108	
9616184-4	1998	We show that human UGT1A3, transiently expressed in human embryonic kidney 293 cells, also catalyzes the N-glucuronidation of primary, secondary, and tertiary amine substrates, such as 4-aminobiphenyl, diphenylamine, and cyproheptadine.	Amines	159-164	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	19-25	
10901693-3	2000	Two UDP-glucuronosyltransferases (UGTs) present in human liver, UGT1A4 and UGT1A3, were previously shown to catalyze tertiary amine N-glucuronidation when expressed in HK293 cells.	Amines	126-131	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	75-81	
10901693-9	2000	The results suggest that UGT1A4 and UGT1A3 catalyze high-K(M) N-glucuronidation of tertiary amine drugs, whereas the low-K(M) reaction requires either an alternative enzyme or a special conformation of UGT1A4 or UGT1A3 that can be attained in liver microsomes, but not in HK293 cell membranes.	Amines	92-97	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	36-42	
10901693-9	2000	The results suggest that UGT1A4 and UGT1A3 catalyze high-K(M) N-glucuronidation of tertiary amine drugs, whereas the low-K(M) reaction requires either an alternative enzyme or a special conformation of UGT1A4 or UGT1A3 that can be attained in liver microsomes, but not in HK293 cell membranes.	Amines	92-97	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	212-218	
9616184-5	1998	In contrast to expressed human UGT1A4, which catalyzes the glucuronidation of amines with high efficiency, glucuronidation of amines catalyzed by UGT1A3 exhibited low efficiency, suggesting that UGT1A3 makes only a limited contribution to the metabolic elimination of these compounds.	Amines	126-132	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	146-152	
9616184-5	1998	In contrast to expressed human UGT1A4, which catalyzes the glucuronidation of amines with high efficiency, glucuronidation of amines catalyzed by UGT1A3 exhibited low efficiency, suggesting that UGT1A3 makes only a limited contribution to the metabolic elimination of these compounds.	Amines	126-132	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	195-201	
9616184-7	1998	In addition to amines, expressed human UGT1A3 catalyzed the glucuronidation of opioids (e.g. morphine and buprenorphine), coumarins, flavonoids (e.g. naringenin and quercetin), anthraquinones, and small phenolic compounds (e.g. 4-nitrophenol).	Amines	15-21	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	39-45