PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14747463-7 2004 Consistent with a late endocytic protein trafficking defect, the hydrophobic amine U18666A retained NPC1 in abnormally tubulated, cholesterol-poor, Tangier disease late endosomes, rather than cholesterol-laden lysosomes, as in wild type fibroblasts. Amines 77-82 NPC intracellular cholesterol transporter 1 Homo sapiens 100-104 18591242-0 2008 Niemann-Pick C1 functions in regulating lysosomal amine content. Amines 50-55 NPC intracellular cholesterol transporter 1 Homo sapiens 0-15 18591242-3 2008 We show here that the introduction of amine-containing molecules in lysosomes can significantly stimulate NPC1-mediated late endosome/lysosome fusion, and subsequently the secretion of lysosomal cargo. Amines 38-43 NPC intracellular cholesterol transporter 1 Homo sapiens 106-110 10666334-7 2000 Incubation of granulosa-lutein cells with low-density lipoprotein (LDL) in the presence of the hydrophobic amine, U18666A, caused accumulation of free cholesterol in granules, identified by filipin staining, that contained LAMP-2 and NPC1. Amines 107-112 NPC intracellular cholesterol transporter 1 Homo sapiens 234-238