PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25056711-1	2015	By catalyzing hydrolysis of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), cyclic nucleotide phosphodiesterases are critical regulators of their intracellular concentrations and their biological effects.	Cyclic GMP	70-100	phosphodiesterase 11A	Homo sapiens	127-145	
33127481-1	2021	Phosphodiesterases catalyze the hydrolysis of cyclic nucleotides and maintain physiologic levels of intracellular concentrations of cyclic adenosine and guanosine mono-phosphate (cAMP and cGMP, respectively).	Cyclic GMP	188-192	phosphodiesterase 11A	Homo sapiens	0-18	
28956334-2	2017	PDE11A is a dual-specific PDE, breaking down both cAMP and cGMP.	Cyclic GMP	59-63	phosphodiesterase 11A	Homo sapiens	0-3	
25056711-1	2015	By catalyzing hydrolysis of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), cyclic nucleotide phosphodiesterases are critical regulators of their intracellular concentrations and their biological effects.	Cyclic GMP	102-106	phosphodiesterase 11A	Homo sapiens	127-145	
25232906-2	2014	Phosphodiesterases (PDEs) are key regulatory enzymes of intracellular cAMP/cGMP levels.	Cyclic GMP	75-79	phosphodiesterase 11A	Homo sapiens	0-18	
25232906-2	2014	Phosphodiesterases (PDEs) are key regulatory enzymes of intracellular cAMP/cGMP levels.	Cyclic GMP	75-79	phosphodiesterase 11A	Homo sapiens	20-24	
17696499-1	2007	The phosphodiesterase-11A (PDE11) family consists of four splice variants (PDE11A1-PDE11A4) that contain a conserved carboxyl-terminal (C-terminal) catalytic domain that hydrolyzes cAMP and cGMP; the amino-termini (N-termini) vary in length and amino acid sequence.	Cyclic GMP	190-194	phosphodiesterase 11A	Homo sapiens	4-25	
19689430-5	2009	PDE10A and PDE11A are the two most recently described PDEs and it has been suggested that their GAF domains bind to cAMP and cGMP respectively.	Cyclic GMP	125-129	phosphodiesterase 11A	Homo sapiens	11-17	
19557111-1	2009	Cyclic nucleotide phosphodiesterases (PDEs) hydrolyze the intracellular second messengers cAMP and cGMP to their corresponding monophosphates.	Cyclic GMP	99-103	phosphodiesterase 11A	Homo sapiens	38-42	
19689430-8	2009	The GAFb domain of PDE10A binds cAMP with a Kd of 48 nM and the GAFa domain of PDE11A binds cGMP with a Kd of 110 nM.	Cyclic GMP	92-96	phosphodiesterase 11A	Homo sapiens	79-85	
17696499-1	2007	The phosphodiesterase-11A (PDE11) family consists of four splice variants (PDE11A1-PDE11A4) that contain a conserved carboxyl-terminal (C-terminal) catalytic domain that hydrolyzes cAMP and cGMP; the amino-termini (N-termini) vary in length and amino acid sequence.	Cyclic GMP	190-194	phosphodiesterase 11A	Homo sapiens	27-32	
10725373-9	2000	Therefore, PDE11A represents a dual-substrate PDE that may regulate both cGMP and cAMP under physiological conditions.	Cyclic GMP	73-77	phosphodiesterase 11A	Homo sapiens	11-17	
11121118-2	2001	PDE11A is a dual-substrate, cAMP and cGMP, cyclic nucleotide phosphodiesterase (PDE).	Cyclic GMP	37-41	phosphodiesterase 11A	Homo sapiens	0-6	
11050148-1	2000	Phosphodiesterase 11A (PDE11A) is a recently identified family of cAMP and cGMP hydrolyzing enzymes.	Cyclic GMP	75-79	phosphodiesterase 11A	Homo sapiens	0-21	
11050148-1	2000	Phosphodiesterase 11A (PDE11A) is a recently identified family of cAMP and cGMP hydrolyzing enzymes.	Cyclic GMP	75-79	phosphodiesterase 11A	Homo sapiens	23-29	
11050148-15	2000	Both PDEs showed a V(max) ratio for cAMP/cGMP of approximately 1.0.	Cyclic GMP	41-45	phosphodiesterase 11A	Homo sapiens	5-9	
15995148-10	2005	Our results suggest that PDE11A might be involved in multiple physiological processes in various organs via its ability to modulate intracellular cAMP and cGMP levels.	Cyclic GMP	155-159	phosphodiesterase 11A	Homo sapiens	25-31	
10725373-10	2000	PDE11A is sensitive to the nonselective PDE inhibitor 3-isobutyl-1-methylxanthine (IBMX) as well as zaprinast and dipyridamole, inhibitors that are generally considered relatively specific for the cGMP-selective PDEs, with IC(50) values of 49.8 microM, 12.0 microM, and 0.37 microM, respectively.	Cyclic GMP	197-201	phosphodiesterase 11A	Homo sapiens	0-6