PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26287183-4	2015	DHTS induced sustained c-Jun N-terminal kinase (JNK) phosphorylation and Fas ligand (FasL) expression.	dhts	0-4	mitogen-activated protein kinase 8	Homo sapiens	23-46	
26283590-7	2015	Moreover, dihydrotanshinone I significantly impaired activation of extracellular signal-regulated kinase 1/2 (ERK1/2), p38 and stress-activated protein kinase/c-Jun NH2-terminal kinase (JNK/SAPK).	dhts	10-29	mitogen-activated protein kinase 8	Homo sapiens	186-194	
26287183-4	2015	DHTS induced sustained c-Jun N-terminal kinase (JNK) phosphorylation and Fas ligand (FasL) expression.	dhts	0-4	mitogen-activated protein kinase 8	Homo sapiens	48-51	
26287183-5	2015	The anti-Fas blocking antibody reversed the DHTS-induced cell death, and the JNK-specific inhibitor, SP600125, inhibited DHTS-induced caspase-3, -8, -9, and PARP cleavage.	dhts	121-125	mitogen-activated protein kinase 8	Homo sapiens	77-80	
26287183-7	2015	Taken together, these results suggest that DHTS can induce HL-60 cell apoptosis in vitro and inhibit HL-60 cell growth in vivo; the underlying mechanisms might be mediated through activation of the JNK and FasL signal pathways.	dhts	43-47	mitogen-activated protein kinase 8	Homo sapiens	198-201	
21274285-4	2011	DHTS was able to induce ER stress as evidenced by the upregulation of glucose regulation protein 78 (GRP78/Bip) and CAAT/enhancer binding protein homologous protein/growth arrest- and DNA damage-inducible gene 153 (CHOP/GADD153), as well as increases in phosphorylated eukaryotic initiation factor 2alpha (eIF2alpha), c-jun N-terminal kinase (JNK), and X-box-binding protein 1 (XBP1) mRNA splicing forms.	dhts	0-4	mitogen-activated protein kinase 8	Homo sapiens	318-341	
21274285-4	2011	DHTS was able to induce ER stress as evidenced by the upregulation of glucose regulation protein 78 (GRP78/Bip) and CAAT/enhancer binding protein homologous protein/growth arrest- and DNA damage-inducible gene 153 (CHOP/GADD153), as well as increases in phosphorylated eukaryotic initiation factor 2alpha (eIF2alpha), c-jun N-terminal kinase (JNK), and X-box-binding protein 1 (XBP1) mRNA splicing forms.	dhts	0-4	mitogen-activated protein kinase 8	Homo sapiens	343-346