PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24021352-6 2013 Its 3-O-Me product, i.e. 8-hydroxy-5-isopropyl-3-methoxy-7-methylbenzo[cd]indol-2(1H)-one, named 3-O-methylthespesilactam, of which the structure was identified by NMR investigations and single-crystal X-ray diffraction analysis, was discovered as a new type of small-molecule anticancer pan-JAK inhibitor against A2058 human melanoma cells, and selective and potent inhibitor of JAK1 and TYK2. 1h)-one 82-89 Janus kinase 1 Homo sapiens 380-384