PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34017341-6 2021 Animal experiments showed that melatonin can not only alleviate chronic lipopolysaccharide (LPS)-induced mouse lung destruction and chronic lung inflammation but also reduce necroptosis (RIP1/RIP3/MLKL), a programmed cell death process in bronchial epithelial cells. Melatonin 31-40 mixed lineage kinase domain-like Mus musculus 197-201 30365930-0 2018 Melatonin attenuates chronic pain related myocardial ischemic susceptibility through inhibiting RIP3-MLKL/CaMKII dependent necroptosis. Melatonin 0-9 mixed lineage kinase domain-like Mus musculus 101-105 30365930-15 2018 We also define melatonin acted as triple cardioprotective effects: ameliorating TNF-alpha level, suppressing RIP3-MLKL/CaMKII signaling induced necroptosis and exerting analgesia effect. Melatonin 15-24 mixed lineage kinase domain-like Mus musculus 114-118