PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28749565-0 2017 Melatonin suppresses platelet activation and function against cardiac ischemia/reperfusion injury via PPARgamma/FUNDC1/mitophagy pathways. Melatonin 0-9 FUN14 domain containing 1 Homo sapiens 112-118 28749565-7 2017 However, melatonin powerfully suppressed platelet activation via restoration of the PPARgamma content in platelets, which subsequently blocked FUNDC1-required mitophagy, mitochondrial energy production, platelet hyperactivity, and cardiac I/R injury. Melatonin 9-18 FUN14 domain containing 1 Homo sapiens 143-149 28749565-9 2017 Our results lay the foundation for the molecular mechanism of platelet activation in response to I/R injury and highlight that the manipulation of the PPARgamma/FUNDC1/mitophagy pathway by melatonin could be a novel strategy for cardioprotection in the setting of cardiac I/R injury. Melatonin 189-198 FUN14 domain containing 1 Homo sapiens 161-167