PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25358700-10	2015	Finally, MEL and 5-MTX promoted activation of the ERK1/2 pathway through the phosphorylation of ERK, while LUZ addition suppressed this effect.	Melatonin	9-12	mitogen-activated protein kinase 3	Mus musculus	50-56	
29029459-0	2017	Melatonin promotes the proliferation of GC-1 spg cells by inducing metallothionein-2 expression through ERK1/2 signaling pathway activation.	Melatonin	0-9	mitogen-activated protein kinase 3	Mus musculus	104-110	
29029459-9	2017	Mechanistic analysis indicated that the extracellular-signal-regulated kinase 1/2 (ERK1/2) pathway participated in melatonin-promoted proliferation of GC-1 spg cells.	Melatonin	115-124	mitogen-activated protein kinase 3	Mus musculus	40-81	
29029459-9	2017	Mechanistic analysis indicated that the extracellular-signal-regulated kinase 1/2 (ERK1/2) pathway participated in melatonin-promoted proliferation of GC-1 spg cells.	Melatonin	115-124	mitogen-activated protein kinase 3	Mus musculus	83-89	
29029459-10	2017	Therefore, melatonin induces the proliferation of GC-spg 1 cells by stimulating Mt2 expression, and this process is mediated by the ERK1/2 signaling pathway.	Melatonin	11-20	mitogen-activated protein kinase 3	Mus musculus	132-138	
26101163-14	2015	In cultured hepatocytes, melatonin treatment prevented the hydrogen peroxide-induced cell death and decrease in phosphorylation of ERK1/2.	Melatonin	25-34	mitogen-activated protein kinase 3	Mus musculus	131-137	
35526594-13	2022	SIGNIFICANCE: Under DZN exposure, melatonin can significantly improve the quality of oocytes, and melatonin promotes oocyte maturation by protecting gap junction and restoring ERK1/2 pathway, which is a new breakthrough for improving female fertility.	Melatonin	98-107	mitogen-activated protein kinase 3	Mus musculus	176-182	
32210763-8	2020	Our data showed that melatonin pretreatment attenuated TOCP-induced autophagy by suppressing oxidative stress and restoring ERK1/2 phosphorylation consistently.	Melatonin	21-30	mitogen-activated protein kinase 3	Mus musculus	124-130	
27736013-5	2017	Persistent ERK1/2 activation was found in both, melatonin and androgen-deprived cells.	Melatonin	48-57	mitogen-activated protein kinase 3	Mus musculus	11-17	
25565776-15	2015	Coff or Caff, plus Mel inhibited GSK3beta, Akt, PI3K p55, and Tau phosphorylation but enhanced PI3K p85 and Erk1/2 phosphorylation in N2a/APP cells.	Melatonin	19-22	mitogen-activated protein kinase 3	Mus musculus	108-114	
19090911-8	2009	In this study we demonstrate the efficacy of treatment with the melatonin in SCI in mice in reducing (a) motor recovery, (b) activation of MAPKs p38, JNK and ERK1/2, (c) tumor necrosis factor-alpha expression, and (d) expression of HMGB1.	Melatonin	64-73	mitogen-activated protein kinase 3	Mus musculus	158-164	
22959068-10	2012	We found elevated phosphorylation of extracellular-regulated kinase (ERK)1/2 and c-Jun N-terminal kinase (JNK) during chronic gastric ulceration, which were significantly reversed by melatonin.	Melatonin	183-192	mitogen-activated protein kinase 3	Mus musculus	37-76	
24589478-12	2014	Furthermore, pretreatment with melatonin prevented DEX-induced reductions in GR and an extracellular-signal-regulated kinase (ERK1/2) in the hippocampal area.	Melatonin	31-40	mitogen-activated protein kinase 3	Mus musculus	126-132	
24589478-13	2014	Melatonin may protect hippocampal neurons from damage and reverse neurogenesis after chronic DEX by activating brain-derived neurotrophic (BDNF) and ERK1/2 cascades.	Melatonin	0-9	mitogen-activated protein kinase 3	Mus musculus	149-155	
24589478-14	2014	These results revealed that melatonin pretreatment prevented the reduction of cell proliferation, immature neuron precursor cells, and GR and ERK1/2 expression.	Melatonin	28-37	mitogen-activated protein kinase 3	Mus musculus	142-148	
23396088-10	2013	However, melatonin increased the activation of Akt and reduced the activations of ERK-1/2, p21, p38/MAPK and SAPK/JNK1/2 significantly.	Melatonin	9-18	mitogen-activated protein kinase 3	Mus musculus	82-89	
23396088-12	2013	Moreover, memantine reversed the effects of melatonin on the activation of ERK-1/2 pathway.	Melatonin	44-53	mitogen-activated protein kinase 3	Mus musculus	75-82	
11684691-5	2002	Melatonin induced protein kinase C activity by 1.65-fold over basal levels, increased the phosphorylation of extracellular signal-regulated kinase 1 and 2 proteins, and activated c-fos and junB mRNA expression in GT1-7 cells.	Melatonin	0-9	mitogen-activated protein kinase 3	Mus musculus	109-154	
11684691-6	2002	Using the protein kinase A inhibitor H-89, the protein kinase C inhibitor bisindolylmaleimide, and the mitogen-activated protein kinase kinase inhibitor PD98059, we found that the melatonin-mediated cyclical regulation of GnRH mRNA expression may involve the protein kinase C and the extracellular signal-regulated kinase 1 and 2 pathways, but not the protein kinase A pathway.	Melatonin	180-189	mitogen-activated protein kinase 3	Mus musculus	284-329