PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34460299-1 2021 Cefalexin is a widely used 1st generation cephalosporin, and resistance in Escherichia coli is caused by Extended-Spectrum (e.g., CTX-M) and AmpC beta-lactamase production and therefore frequently coincides with 3rd generation cephalosporin resistance. Cephalexin 0-9 beta-lactamase Escherichia coli 141-145 356181-2 1978 In a prospective study of patients treated with cephalexin or co-trimoxazole, almost all isolated E. coli strains of intermediate susceptibility to ampicillin or cephalosporin (MIC 2-16 microgram/ml) were shown to produce beta-lactamase detectable with a chromogenic cephalosporin substrate, or by the clover-leaf test or the acidimetric method. Cephalexin 48-58 beta-lactamase Escherichia coli 222-236 356181-4 1978 In order to evaluate the clinical significance of this beta-lactamase production, 48 patients with urinary tract infection (UTI) were treated with cephalexin, an antibiotic hydrolysed by the enzyme. Cephalexin 147-157 beta-lactamase Escherichia coli 55-69 6335045-9 1984 Antibiotic resistance to Ampicillin, Cephaloridine, Cephalexine and Cefazolin observed in receiving strains after conjugation is not only due to beta-lactamase transfer. Cephalexin 52-63 beta-lactamase Escherichia coli 145-159