PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9242187-1 1997 Epoxyeicosatrienoic acids (EETs) are potent endothelium-derived vasodilators formed from cytochrome P-450 metabolism of arachidonic acid. eets 27-31 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 89-105 10924087-1 2000 Epoxyeicosatrienoic acids (EETs) are cytochrome P-450 metabolites of arachidonic acid involved in the regulation of vascular tone. eets 27-31 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 37-53 9430380-1 1997 Arachidonic acid is converted to epoxyeicosatrienoic acids (EETs) by cytochrome P450 monooxygenases. eets 60-64 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 69-84 11195057-1 2001 Recent studies indicate that arachidonic acid is primarily metabolized by cytochrome P450 enzymes of the 4A and 2C families in the kidney to 20-hydroxyeicosatetraenoic acid (HETE), epoxyeicosatrienoic acids (EETs) and dihydroxyeicosatrienoic acids. eets 208-212 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 74-89 30400671-2 2018 Arachidonic acid (AA) is metabolized by cytochrome P450 (CYP450) enzymes to epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE), vasoactive and natriuretic metabolites that contribute to blood pressure (BP) regulation. eets 103-107 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 40-55 8388882-1 1993 Epoxyeicosatrienoic acids (EETs), cytochrome P-450 metabolites of arachidonic acid, have attracted attention because of their effects on stimulus-response coupling in endocrine, renal, and vascular cells. eets 27-31 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 34-50 33095237-7 2020 CYP enzymes produce two types of eicosanoid products: EDHF vasodilator epoxyeicosatrienoic acids (EETs) and the vasoconstrictor 20-HETE. eets 98-102 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-3 7625847-3 1995 Liver CYP arachidonate products include epoxyeicosatrienoic acids (EETs) and monohydroxylated products (HETEs). eets 67-71 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 6-9 30560267-4 2018 CYP450 epoxygenase metabolites epoxyeicosatrienoic acids (EETs) are mainly produced in renal microvessels. eets 58-62 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-6 30400671-2 2018 Arachidonic acid (AA) is metabolized by cytochrome P450 (CYP450) enzymes to epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE), vasoactive and natriuretic metabolites that contribute to blood pressure (BP) regulation. eets 103-107 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 57-63 29908721-1 2018 CYP2C and CYP2 J enzymes, commonly named as cytochrome P450 (CYP) epoxygenases, convert arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EETs), biologically active eicosanoids with many functions in organism. eets 154-158 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 44-59 30066055-2 2018 CYP-derived AA epoxides, called epoxyeicosatrienoic acids (EETs), also promote the growth of tumor epithelia. eets 59-63 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-3 29908721-1 2018 CYP2C and CYP2 J enzymes, commonly named as cytochrome P450 (CYP) epoxygenases, convert arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EETs), biologically active eicosanoids with many functions in organism. eets 154-158 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-3 27591243-1 2016 Epoxyeicosatrienoic acids (EETs) are metabolic products of free arachidonic acid, which are produced through cytochrome P-450 (CYP) epoxygenases. eets 27-31 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 109-125 28007573-1 2017 OBJECTIVE: Prominent among the endothelium-derived hyperpolarizing factors (EDHFs) are the Cytochrome P450 (CYP) epoxygenase-derived arachidonic acid metabolites-the epoxyeicosatrienoic acids (EETs), that are known as vasodilators in the microcirculation. eets 193-197 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 91-106 28007573-1 2017 OBJECTIVE: Prominent among the endothelium-derived hyperpolarizing factors (EDHFs) are the Cytochrome P450 (CYP) epoxygenase-derived arachidonic acid metabolites-the epoxyeicosatrienoic acids (EETs), that are known as vasodilators in the microcirculation. eets 193-197 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 108-111 27591243-1 2016 Epoxyeicosatrienoic acids (EETs) are metabolic products of free arachidonic acid, which are produced through cytochrome P-450 (CYP) epoxygenases. eets 27-31 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 127-130 26975734-1 2016 Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid to generate epoxyeicosatrienoic acids (EETs). eets 102-106 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 27087514-1 2016 AIM: To better understand the relationship between the interactions among rs17110453, rs751141, and rs9333025 variants and plasma levels of cytochrome P450 (CYP) metabolites, i.e.,20-hydroxyeicosatetraenoic acid (20-HETE), epoxyeicosatrienoic acids (EETs), and dihydroxyeicosatrienoic acids (DiHETEs) in ischemia stroke (IS). eets 250-254 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 157-160 26975734-1 2016 Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid to generate epoxyeicosatrienoic acids (EETs). eets 102-106 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 17-20 27115337-1 2016 BACKGROUND: Epoxyeicosatrienoic acids (EETs) derived from cytochrome P450 (CYP)-dependent metabolism of arachidonic acid are increased in the plasma of women with preeclampsia as compared with normal pregnancy and are significantly higher in fetal than in maternal plasma and erythrocytes. eets 39-43 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 58-73 27115337-1 2016 BACKGROUND: Epoxyeicosatrienoic acids (EETs) derived from cytochrome P450 (CYP)-dependent metabolism of arachidonic acid are increased in the plasma of women with preeclampsia as compared with normal pregnancy and are significantly higher in fetal than in maternal plasma and erythrocytes. eets 39-43 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 75-78 25151892-1 2014 Previous studies have indicated that cytochrome P450 (CYP) metabolites of arachidonic acid (AA), i.e., 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs), play an important role in the regulation of renal tubular and vascular function. eets 176-180 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 37-52 27079253-3 2016 Epoxyecosatrienoic acids (EETs), the products of arachidonic acid metabolism mediated by cytochrome P450 (CYP) 2J, 2C and other isoforms, are regulated by soluble epoxide hydrolase (sEH)-catalyzed conversion into less active diols. eets 26-30 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 89-104 27079253-3 2016 Epoxyecosatrienoic acids (EETs), the products of arachidonic acid metabolism mediated by cytochrome P450 (CYP) 2J, 2C and other isoforms, are regulated by soluble epoxide hydrolase (sEH)-catalyzed conversion into less active diols. eets 26-30 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 106-109 27451096-3 2016 The CYP pathway produces two types of eicosanoid products: epoxyeicosatrienoic acids (EETs), formed by CYP epoxygenases, and hydroxyeicosatetraenoic acids (HETEs), formed by CYP hydroxylases. eets 86-90 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 4-7 27451096-3 2016 The CYP pathway produces two types of eicosanoid products: epoxyeicosatrienoic acids (EETs), formed by CYP epoxygenases, and hydroxyeicosatetraenoic acids (HETEs), formed by CYP hydroxylases. eets 86-90 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 103-106 27451096-3 2016 The CYP pathway produces two types of eicosanoid products: epoxyeicosatrienoic acids (EETs), formed by CYP epoxygenases, and hydroxyeicosatetraenoic acids (HETEs), formed by CYP hydroxylases. eets 86-90 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 103-106 25426071-1 2014 Epoxyeicosatrienoic acids (EETs) generated from arachidonic acid through cytochrome P450 (CYP) epoxygenases have many biological functions. eets 27-31 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 73-88 25426071-1 2014 Epoxyeicosatrienoic acids (EETs) generated from arachidonic acid through cytochrome P450 (CYP) epoxygenases have many biological functions. eets 27-31 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 90-93 27100515-1 2016 Cytochrome P450s enzymes catalyze the metabolism of arachidonic acid to epoxyeicosatrienoic acids (EETs), dihydroxyeicosatetraenoic acid and hydroxyeicosatetraeonic acid (HETEs). eets 99-103 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 27144772-1 2016 Soluble epoxide hydrolase (sEH) converts highly active epoxyeicosatrienoic acids (EETs) generated by cytochrome P450 (CYP) epoxygenases from arachidonic acid to less active dihydroxyeicosatrienoic acids. eets 82-86 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 101-116 27144772-1 2016 Soluble epoxide hydrolase (sEH) converts highly active epoxyeicosatrienoic acids (EETs) generated by cytochrome P450 (CYP) epoxygenases from arachidonic acid to less active dihydroxyeicosatrienoic acids. eets 82-86 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 118-121 24882266-2 2014 The main human CYP epoxygenases, i.e. CYP2C8, CYP2C9, CYP2C19 and CYP2J2, convert AA to four regioisomer epoxyeicosatrienoic acids (EETs). eets 132-136 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 15-18 25151892-1 2014 Previous studies have indicated that cytochrome P450 (CYP) metabolites of arachidonic acid (AA), i.e., 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs), play an important role in the regulation of renal tubular and vascular function. eets 176-180 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 54-57 23619744-8 2013 Surprisingly, the CYP metabolites of AA, epoxyeicosatrienoic acids (EETs), were much less potent activators of TRPV4, and CYP inhibitors did not affect EET production in HCAECs. eets 68-72 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 18-21 24096258-2 2013 Cytochrome P450 (CYP450) eicosanoids derived from arachidonic acid include vasodilator epoxyeicosatrienoic acids (EETs) and the vasoconstrictor 20-hydroxyeicosatrienoic acid (20-HETE). eets 114-118 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 24096258-2 2013 Cytochrome P450 (CYP450) eicosanoids derived from arachidonic acid include vasodilator epoxyeicosatrienoic acids (EETs) and the vasoconstrictor 20-hydroxyeicosatrienoic acid (20-HETE). eets 114-118 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 17-23 24216999-2 2013 Cytochrome P450 (CYP) activity and synthesis of both epoxyeicosatrienoic acids (EETs) and 20-hydroxy-5,8,11,14-eicosatetraenoic acid (20-HETE), together with vascular endothelial growth factor (VEGF) and heme oxygenase system (HO) have emerged as important modulators of tumor growth and metastasis. eets 80-84 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 24216999-2 2013 Cytochrome P450 (CYP) activity and synthesis of both epoxyeicosatrienoic acids (EETs) and 20-hydroxy-5,8,11,14-eicosatetraenoic acid (20-HETE), together with vascular endothelial growth factor (VEGF) and heme oxygenase system (HO) have emerged as important modulators of tumor growth and metastasis. eets 80-84 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 17-20 25024195-1 2014 Prostaglandins derived from the cyclooxygenase (COX) pathway and epoxyeicosatrienoic acids (EETs) from the cytochrome P450/soluble epoxide hydrolase (sEH) pathway are important eicosanoids that regulate angiogenesis and tumorigenesis. eets 92-96 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 107-148 22975950-1 2012 Epoxyeicosatrienoic acids (EETs) produced by cytochrome P450 (CYP)-dependent epoxidation of arachidonic acid (AA) inhibit thrombocyte adhesion to the vascular wall. eets 27-31 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 45-60 22621785-3 2012 Epoxyeicosatrienoic acids (EETs), products of cytochrome P-450 epoxidation of arachidonic acid, have vasculoprotective and anti-inflammatory effects including inhibition of platelet activation, cell migration, and adhesion. eets 27-31 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 46-62 22173545-2 2012 Cytochrome P450 (CYP)-derived metabolites of arachidonic acid such as epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE), active on vascular tone, endothelial function and renal sodium reapportion, have been identified as candidate mediators in the development of hypertension in several animal models, with remarkable sex-specific effect. eets 97-101 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 22173545-2 2012 Cytochrome P450 (CYP)-derived metabolites of arachidonic acid such as epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE), active on vascular tone, endothelial function and renal sodium reapportion, have been identified as candidate mediators in the development of hypertension in several animal models, with remarkable sex-specific effect. eets 97-101 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 17-20 22975950-1 2012 Epoxyeicosatrienoic acids (EETs) produced by cytochrome P450 (CYP)-dependent epoxidation of arachidonic acid (AA) inhibit thrombocyte adhesion to the vascular wall. eets 27-31 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 62-65 22848834-1 2012 Epoxyeicosatrienoic acids (EETs) are generated by the activity of both selective and also more general cytochrome p450 (CYP) enzymes on arachidonic acid and inactivated largely by soluble epoxide hydrolase (sEH), which converts them to their corresponding dihydroxyeicosatrienoic acids (DHETs). eets 27-31 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 103-118 22848834-1 2012 Epoxyeicosatrienoic acids (EETs) are generated by the activity of both selective and also more general cytochrome p450 (CYP) enzymes on arachidonic acid and inactivated largely by soluble epoxide hydrolase (sEH), which converts them to their corresponding dihydroxyeicosatrienoic acids (DHETs). eets 27-31 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 120-123 22182836-1 2012 Epoxyeicosatrienoic acids (EETs) generated from arachidonic acid by cytochrome P450 (CYP) epoxygenases have beneficial effects in certain cardiovascular and kidney diseases. eets 27-31 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 68-83 22182836-1 2012 Epoxyeicosatrienoic acids (EETs) generated from arachidonic acid by cytochrome P450 (CYP) epoxygenases have beneficial effects in certain cardiovascular and kidney diseases. eets 27-31 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 85-88 21476972-6 2011 CYP isoforms expressed in the heart are critical for generation of epoxyeicosatrienoic acids (EETs) and ROS. eets 94-98 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-3 21356152-1 2011 The eicosanoids 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs), which are generated from the metabolism of arachidonic acid by cytochrome P450 (CYP) enzymes, possess a wide array of biological actions, including the regulation of blood flow to organs. eets 89-93 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 159-174 21356152-1 2011 The eicosanoids 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs), which are generated from the metabolism of arachidonic acid by cytochrome P450 (CYP) enzymes, possess a wide array of biological actions, including the regulation of blood flow to organs. eets 89-93 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 176-179 19891972-1 2010 The cytochrome P450 (CYP) epoxygenase enzymes CYP2J and CYP2C catalyze the epoxidation of arachidonic acid to epoxyeicosatrienoic acids (EETs), which are rapidly hydrolyzed to dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH). eets 137-141 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 4-19 20378604-2 2010 The CYP-mediated epoxyeicosatrienoates (EETs) have been described previously as the predominant eicosanoids in human lungs upon stimulation with the Ca(2+) ionophore A23187. eets 40-44 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 4-7 20493836-1 2010 Epoxyeicosatrienoic acids (EETs), metabolites of arachidonic acid (AA) catalyzed by cytochrome P450 (CYP), have many essential biologic roles in the cardiovascular system including inhibition of apoptosis in cardiomyocytes. eets 27-31 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 84-99 20493836-1 2010 Epoxyeicosatrienoic acids (EETs), metabolites of arachidonic acid (AA) catalyzed by cytochrome P450 (CYP), have many essential biologic roles in the cardiovascular system including inhibition of apoptosis in cardiomyocytes. eets 27-31 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 101-104 19891972-1 2010 The cytochrome P450 (CYP) epoxygenase enzymes CYP2J and CYP2C catalyze the epoxidation of arachidonic acid to epoxyeicosatrienoic acids (EETs), which are rapidly hydrolyzed to dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH). eets 137-141 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 21-24 16380164-1 2006 Epoxyeicosatrienoic acids (EETs) are generated from arachidonic acid by cytochrome P450 (CYP) epoxygenases. eets 27-31 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 72-87 17872452-2 2007 Here we address the mechanisms by which cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) contribute to this effect in native and cultured endothelial cells. eets 97-101 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 40-55 17872452-2 2007 Here we address the mechanisms by which cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) contribute to this effect in native and cultured endothelial cells. eets 97-101 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 57-60 17764757-1 2007 Cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) are lipid signalling molecules that elicit vasodilatation and modulate various intracellular signalling cascades. eets 57-61 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 17764757-1 2007 Cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) are lipid signalling molecules that elicit vasodilatation and modulate various intracellular signalling cascades. eets 57-61 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 17-20 17164129-4 2007 A number of these enzymes, including members of the CYP 4 family, predominantly catalyze conversion of AA to 20-hydroxyeicosatetraenoic acid (20-HETE) while the CYP epoxygenases generate mainly epoxyeicosatrienoic acids (EETs). eets 221-225 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 52-55 17164129-4 2007 A number of these enzymes, including members of the CYP 4 family, predominantly catalyze conversion of AA to 20-hydroxyeicosatetraenoic acid (20-HETE) while the CYP epoxygenases generate mainly epoxyeicosatrienoic acids (EETs). eets 221-225 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 161-164 17164133-1 2007 Epoxyeicosatrienoic acids (EETs) are generated from arachidonic acid by cytochrome P450 (CYP) epoxygenases the expression of which is determined by hemodynamic and pharmacological stimuli as well as by hypoxia. eets 27-31 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 72-87 17164133-1 2007 Epoxyeicosatrienoic acids (EETs) are generated from arachidonic acid by cytochrome P450 (CYP) epoxygenases the expression of which is determined by hemodynamic and pharmacological stimuli as well as by hypoxia. eets 27-31 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 89-92 19549792-1 2009 Cytochrome P-450 (CYP450) enzymes of the CYP2 and -4 family in humans metabolize arachidonic acid to generate bioactive epoxyeicosatrienenoic acids (EETs) and hydroxyeicosatetrenoic acids (HETEs). eets 149-153 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-16 19549792-1 2009 Cytochrome P-450 (CYP450) enzymes of the CYP2 and -4 family in humans metabolize arachidonic acid to generate bioactive epoxyeicosatrienenoic acids (EETs) and hydroxyeicosatetrenoic acids (HETEs). eets 149-153 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 18-24 16380164-1 2006 Epoxyeicosatrienoic acids (EETs) are generated from arachidonic acid by cytochrome P450 (CYP) epoxygenases. eets 27-31 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 89-92 16490839-1 2006 Epoxyeicosatrienoic acids (EETs) are epoxides of arachidonic acid generated by cytochrome P450 (CYP) epoxygenases. eets 27-31 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 79-94 16490839-1 2006 Epoxyeicosatrienoic acids (EETs) are epoxides of arachidonic acid generated by cytochrome P450 (CYP) epoxygenases. eets 27-31 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 96-99 16291720-1 2005 Recent studies suggest that cytochrome P450 (CYP) epoxygenase-derived epoxyeicosatrienoic acids (EETs) elicit cell proliferation and promote angiogenesis. eets 97-101 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 28-43 16291720-1 2005 Recent studies suggest that cytochrome P450 (CYP) epoxygenase-derived epoxyeicosatrienoic acids (EETs) elicit cell proliferation and promote angiogenesis. eets 97-101 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 45-48 16178456-1 2005 Interests on the effects of cytochrome P450 (CYP450) monooxygenases and epoxyeicosatrienoic acids (EETs) on myocardial ischemic-reperfusion injury has been increased in recent years. eets 99-103 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 45-51 12892558-3 2003 In particular, there has been considerable support for a role for the cytochrome P450 metabolites, the epoxyeicosatrienoic acids (EETs). eets 130-134 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 70-85 15503650-4 2004 Cytochrome P450 metabolism of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE) or epoxyeicosatrienoic acids (EETs) provides a mechanism for the constriction and relaxation of cerebral arteries, respectively. eets 122-126 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 15145985-8 2004 Moreover, vicinal diol from both C18-epoxides and EETs were omega-hydroxylated by liver microsomes and by CYP4F2 and CYP4F3. eets 50-54 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 117-123 14626496-2 2003 CYP-AA metabolites, 19- and 20-hydroxyeicosatetraenoic acids (HETEs), epoxyeicosatrienoic acids (EETs) and diHETEs have different biological properties based on sites of production and can be stored in tissue lipids and released in response to hormonal stimuli. eets 97-101 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-3 11773611-1 2002 Recent studies have indicated that arachidonic acid is primarily metabolized by cytochrome P-450 (CYP) enzymes in the brain, lung, kidney, and peripheral vasculature to 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) and that these compounds play critical roles in the regulation of renal, pulmonary, and cardiac function and vascular tone. eets 242-246 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 80-96 11773611-1 2002 Recent studies have indicated that arachidonic acid is primarily metabolized by cytochrome P-450 (CYP) enzymes in the brain, lung, kidney, and peripheral vasculature to 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) and that these compounds play critical roles in the regulation of renal, pulmonary, and cardiac function and vascular tone. eets 242-246 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 98-101