PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20093140-4 2010 CYP epoxygenases such as CYP1A2, CYP2C, and CYP2J2 metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs) which generally possess vasodilating, anti-inflammatory, anti-apoptotic, anti-thrombotic, natriuretic, and cardioprotective effects. epoxyeicosatrienoic acids 82-107 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 33-38 19891972-1 2010 The cytochrome P450 (CYP) epoxygenase enzymes CYP2J and CYP2C catalyze the epoxidation of arachidonic acid to epoxyeicosatrienoic acids (EETs), which are rapidly hydrolyzed to dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH). epoxyeicosatrienoic acids 110-135 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 56-61 17220242-1 2007 The cytochrome P450 (P450) enzymes CYP2C8, CYP2C9, and CYP2J2 metabolize arachidonic acid to epoxyeicosatrienoic acids, which are known to be vital in regulation of vascular tone and cardiovascular homeostasis. epoxyeicosatrienoic acids 93-118 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 43-49 18496133-2 2008 CYP2J2, CYP2C8, and CYP2C9 are known to be a source of epoxyeicosatrienoic acids in cardiac tissues. epoxyeicosatrienoic acids 55-80 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 20-26 15840038-2 2005 Recent studies suggest that an endothelial cytochrome P450 (CYP) epoxygenase (CYP 2C9) can modulate endothelium-dependent vasodilatation in two different ways: (1) by the production of epoxyeicosatrienoic acids (EETs), which elicit hyperpolarization and relaxation; and (2) by the release of oxygen-derived free radicals, which compromise the bioavailability of nitric oxide. epoxyeicosatrienoic acids 185-210 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 78-85 15652503-0 2005 Biosynthesis of epoxyeicosatrienoic acids varies between polymorphic CYP2C enzymes. epoxyeicosatrienoic acids 16-41 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 69-74 15652503-1 2005 Arachidonic acid is oxidized by cytochromes P450 2C (CYP2C) to epoxyeicosatrienoic acids (EETs), possessing vasoactive properties, with 11,12-EET as the endothelium derived hyperpolarization factor. epoxyeicosatrienoic acids 63-88 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 32-51 15652503-1 2005 Arachidonic acid is oxidized by cytochromes P450 2C (CYP2C) to epoxyeicosatrienoic acids (EETs), possessing vasoactive properties, with 11,12-EET as the endothelium derived hyperpolarization factor. epoxyeicosatrienoic acids 63-88 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 53-58 8687505-8 1996 The precocious expression of CYP2C in SIDS could result in a higher production of epoxyeicosatrienoic acids in the neonate, believed to act as relaxant of pulmonary smooth muscles. epoxyeicosatrienoic acids 82-107 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 29-34 12586744-0 2003 Cytochrome P450 2C9-derived epoxyeicosatrienoic acids induce angiogenesis via cross-talk with the epidermal growth factor receptor (EGFR). epoxyeicosatrienoic acids 28-53 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 0-19 11964373-2 2002 Here, we assessed the mechanisms by which the epoxyeicosatrienoic acids (EETs) generated by a CYP 2C enzyme control interendothelial gap junctional communication. epoxyeicosatrienoic acids 46-71 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 94-100 30012669-1 2018 Increased expression of cytochrome P450 CYP2C9, together with elevated levels of its products epoxyeicosatrienoic acids (EET), is associated with aggressiveness in cancer. epoxyeicosatrienoic acids 94-119 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 40-46 32294527-1 2020 Epoxyeicosatrienoic acids (EETs) are synthetized from arachidonic acid by the action of members of the CYP2C and CYP2J subfamilies of cytochrome P450 (CYPs). epoxyeicosatrienoic acids 0-25 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 103-108 25560582-3 2015 CYP2C8, CYP2C9 and CYP2J2 gene involved in the metabolism of arachidonic acid, generates epoxyeicosatrienoic acids (EETs) that mediate dilation of coronary arteries improving post-ischemic cardiac contractile function, reduce vascular inflammation, and increase intravascular fibrinolysis. epoxyeicosatrienoic acids 89-114 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 8-14 28374982-1 2017 Cytochrome P450 (CYP) 2C9, CYP2C8 and CYP2J2 enzymes, which metabolize arachidonic acid (AA) to epoxyeicosatrienoic acids, have cardioprotective effects including anti-inflammation and vasodilation. epoxyeicosatrienoic acids 96-121 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 0-25 26632190-1 2015 Arachidonic acid (AA) is metabolized to epoxyeicosatrienoic acids (EETs) via cytochrome enzymes such as CYP 2C9, 2C8 and 2J2. epoxyeicosatrienoic acids 40-65 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 104-111 24302581-3 2014 In this study, we show that targeting the formation of proangiogenic epoxyeicosatrienoic acids (EET) by the cytochrome P450 arachidonic acid epoxygenases (Cyp2c) represents a new and safe mechanism to treat NSCLC growth and progression. epoxyeicosatrienoic acids 69-94 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 155-160 24882266-2 2014 The main human CYP epoxygenases, i.e. CYP2C8, CYP2C9, CYP2C19 and CYP2J2, convert AA to four regioisomer epoxyeicosatrienoic acids (EETs). epoxyeicosatrienoic acids 105-130 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 46-52 25182955-1 2014 BACKGROUND: Cytochrome P450 (CYP) 2C9 is expressed in the vascular endothelium and metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs), which have the crucial role in the modulation of cardiovascular homeostasis. epoxyeicosatrienoic acids 135-160 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 12-37