PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8897950-1 1996 Arachidonic acid (AA) is metabolized by the cytochrome P-450 (P-450) epoxygenase pathway to epoxyeicosatrienoic acids (EETs) in the brain parenchymal tissue and perivascular astrocytes. epoxyeicosatrienoic acids 92-117 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 44-60 6411091-2 1983 Epoxyeicosatrienoic acids, products of the cytochrome P-450-NADPH dependent arachidonic acid epoxygenase activity, are potent and selective mediators for the in vitro release of either insulin or glucagon from preparations of isolated rat pancreatic islets. epoxyeicosatrienoic acids 0-25 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 43-65 2124686-1 1990 In the presence of NADPH cytochrome P-450-dependent monooxygenases oxidize arachidonic acid giving rise to four epoxyeicosatrienoic acids (EETs) which are hydrolyzed enzymatically to dihydroxyeicosatrienoic acids (DHETs). epoxyeicosatrienoic acids 112-137 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 25-41 2584196-5 1989 These results demonstrate the enzymatic origin of the epoxyeicosatrienoic acids present in rat liver and document a novel metabolic function for cytochrome P-450 in the regio- and enatioselective epoxygenation of endogenous pools of arachidonic acid. epoxyeicosatrienoic acids 54-79 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 145-161 8205390-5 1994 Regioselectivity of arachidonic acid oxygenation was observed in suncus liver microsomes; rat liver microsomal cytochrome P-450 generated epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acid as major products while the cytochrome P-450-dependent monooxygenase in suncus liver microsomes yielded omega- and (omega-1)-hydroxyarachidonic acids as major reaction products. epoxyeicosatrienoic acids 138-163 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 111-127 1968382-1 1990 The epoxyeicosatrienoic acids (EETs) were discovered as products of a cyclooxygenase/lipoxygenase-independent, cytochrome P-450 catalyzed metabolism of arachidonic acid (AA) termed the "epoxygenase" pathway. epoxyeicosatrienoic acids 4-29 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 111-127 22189162-1 2011 Accumulating evidence suggests that cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into epoxyeicosatrienoic acids (EETs) which play important roles in various pathophysiological processes. epoxyeicosatrienoic acids 104-129 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 36-51 29290096-2 2018 CYP-450 epoxygenase metabolizes AA to epoxyeicosatrienoic acids (EETs). epoxyeicosatrienoic acids 38-63 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 0-7 29427791-2 2018 Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acids to form epoxyeicosatrienoic acids (EETs), which exert beneficial roles in the cardiovascular system, but their role in alcoholic cardiomyopathy is elusive. epoxyeicosatrienoic acids 72-97 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 0-15 29427791-2 2018 Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acids to form epoxyeicosatrienoic acids (EETs), which exert beneficial roles in the cardiovascular system, but their role in alcoholic cardiomyopathy is elusive. epoxyeicosatrienoic acids 72-97 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 17-20 27782740-2 2017 Recent studies have revealed striking differences in the role of epoxyeicosatrienoic acids (EETs), active products of cytochrome P-450-dependent epoxygenase pathway of arachidonic acid, in the progression of aorto-caval fistula (ACF)-induced CHF between hypertensive Ren-2 renin transgenic rats (TGR) and transgene-negative normotensive Hannover Sprague-Dawley (HanSD) controls. epoxyeicosatrienoic acids 65-90 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 118-134 27358055-5 2016 Cytochrome P-450 epoxygenase metabolites of arachidonic acid, epoxyeicosatrienoic acids (EETs), have potent vasodilator and antihypertensive properties in addition to many cytoprotective effects, but their effects on CNI-induced nephrotoxicity have not been explored. epoxyeicosatrienoic acids 62-87 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 0-16 26545915-3 2016 Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid to biologically active eicosanoids called epoxyeicosatrienoic acids (EETs), which are further converted by soluble epoxide hydrolase (sEH) to less bioactive diols. epoxyeicosatrienoic acids 105-130 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 0-15 26545915-3 2016 Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid to biologically active eicosanoids called epoxyeicosatrienoic acids (EETs), which are further converted by soluble epoxide hydrolase (sEH) to less bioactive diols. epoxyeicosatrienoic acids 105-130 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 17-20 25936480-2 2015 Cytochrome P-450 (CYP) is a variegated family of enzymes that, among many other activities, metabolize arachidonic acid to the vasoactive epoxyeicosatrienoic acids (EETs). epoxyeicosatrienoic acids 138-163 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 0-16 25936480-2 2015 Cytochrome P-450 (CYP) is a variegated family of enzymes that, among many other activities, metabolize arachidonic acid to the vasoactive epoxyeicosatrienoic acids (EETs). epoxyeicosatrienoic acids 138-163 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 18-21 23967089-3 2013 Epoxyeicosatrienoic acids (EETs) are anti-inflammatory molecules synthesized by various cytochrome P450 (Cyp) enzymes from arachidonic acid. epoxyeicosatrienoic acids 0-25 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 88-103 23967089-3 2013 Epoxyeicosatrienoic acids (EETs) are anti-inflammatory molecules synthesized by various cytochrome P450 (Cyp) enzymes from arachidonic acid. epoxyeicosatrienoic acids 0-25 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 105-108 22189162-1 2011 Accumulating evidence suggests that cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into epoxyeicosatrienoic acids (EETs) which play important roles in various pathophysiological processes. epoxyeicosatrienoic acids 104-129 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 53-56 21753077-1 2011 Cytochrome P-450 metabolites of arachidonic acid, the epoxyeicosatrienoic acids (EETs) and hydrogen peroxide (H(2)O(2)), are important signaling molecules in the kidney. epoxyeicosatrienoic acids 54-79 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 0-16 19940786-1 2010 OBJECTIVE: The contribution of epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE) as cytochrome P-450 metabolites of arachidonic acid in the regulation of the nonclipped kidney function in two-kidney, one-clip (2K1C) Goldblatt hypertensive rats was investigated during the phases of initial and stable hypertension, that is, 7 or 27 days after clipping, respectively. epoxyeicosatrienoic acids 31-56 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 113-129 21411763-2 2011 A previous study indicated that bioavailability of cytochrome P-450 metabolites epoxyeicosatrienoic acids (EETs) is decreased while that of 20-hydroxyeicosatetraenoic acids (20-HETE) is increased in this model. epoxyeicosatrienoic acids 80-105 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 51-67 20045729-1 2010 Cytochrome P450 (CYP) generated cardioprotective metabolites, epoxyeicosatrienoic acids (EETs), and cardiotoxic metabolites, hydroxyeicosatetraenoic acids (HETEs) levels are determined by many factors, including the induction or repression of the CYP enzymes, responsible for their formation. epoxyeicosatrienoic acids 62-87 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 0-15 20045729-1 2010 Cytochrome P450 (CYP) generated cardioprotective metabolites, epoxyeicosatrienoic acids (EETs), and cardiotoxic metabolites, hydroxyeicosatetraenoic acids (HETEs) levels are determined by many factors, including the induction or repression of the CYP enzymes, responsible for their formation. epoxyeicosatrienoic acids 62-87 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 17-20 16793897-1 2006 We have reported that epoxyeicosatrienoic acids (EETs), the cytochrome P450 (CYP) epoxygenase metabolites of arachidonic acid (AA), are potent sarcolemmal ATP-sensitive K+ (KATP) channel activators. epoxyeicosatrienoic acids 22-47 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 60-75 20050826-1 2010 Recent studies have shown that the renal CYP450 (cytochrome P450) metabolites of AA (arachidonic acid), the vasoconstrictor 20-HETE (20-hydroxyeicosatetraenoic acid) and the vasodilator EETs (epoxyeicosatrienoic acids), play an important role in the pathophysiology of AngII (angiotensin II)-dependent forms of hypertension and the associated target organ damage. epoxyeicosatrienoic acids 192-217 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 41-47 20050826-1 2010 Recent studies have shown that the renal CYP450 (cytochrome P450) metabolites of AA (arachidonic acid), the vasoconstrictor 20-HETE (20-hydroxyeicosatetraenoic acid) and the vasodilator EETs (epoxyeicosatrienoic acids), play an important role in the pathophysiology of AngII (angiotensin II)-dependent forms of hypertension and the associated target organ damage. epoxyeicosatrienoic acids 192-217 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 49-64 18276983-2 2008 The Cytochrome P450 (CYP)-derived eicosanoids, 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) have been implicated in the regulation of blood pressure via their vasoactive properties as vasoconstrictors and vasodilators, respectively, as well as via inhibition and activation of endothelial nitric oxide synthase. epoxyeicosatrienoic acids 93-118 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 4-19 18276983-2 2008 The Cytochrome P450 (CYP)-derived eicosanoids, 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) have been implicated in the regulation of blood pressure via their vasoactive properties as vasoconstrictors and vasodilators, respectively, as well as via inhibition and activation of endothelial nitric oxide synthase. epoxyeicosatrienoic acids 93-118 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 21-24 16793897-1 2006 We have reported that epoxyeicosatrienoic acids (EETs), the cytochrome P450 (CYP) epoxygenase metabolites of arachidonic acid (AA), are potent sarcolemmal ATP-sensitive K+ (KATP) channel activators. epoxyeicosatrienoic acids 22-47 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 77-80 15383399-1 2005 Epoxyeicosatrienoic acids (EETs), which belong to cytochrome P-450 (CYP)-derived eicosanoids, have been implicated to vasodilate renal arterioles, inhibit sodium transport in the nephron, and regulate blood pressure in several animal models. epoxyeicosatrienoic acids 0-25 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 50-66 15814528-1 2005 Cytochrome P-450 (CYP)-dependent epoxyeicosatrienoic acids (EETs) dilate rat preglomerular microvessels when adenosine(2A) receptors (A(2A)R) are stimulated. epoxyeicosatrienoic acids 33-58 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 0-16 15814528-1 2005 Cytochrome P-450 (CYP)-dependent epoxyeicosatrienoic acids (EETs) dilate rat preglomerular microvessels when adenosine(2A) receptors (A(2A)R) are stimulated. epoxyeicosatrienoic acids 33-58 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 18-21 15383399-1 2005 Epoxyeicosatrienoic acids (EETs), which belong to cytochrome P-450 (CYP)-derived eicosanoids, have been implicated to vasodilate renal arterioles, inhibit sodium transport in the nephron, and regulate blood pressure in several animal models. epoxyeicosatrienoic acids 0-25 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 68-71 15329052-3 2004 It has been proposed that ACh elicits a hyperpolarization of the coronary endothelial cells which may be accompanied by the activation of cytochrome P450 (CYP) and the resulting release of epoxyeicosatrienoic acids (EETs). epoxyeicosatrienoic acids 189-214 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 155-158 14670845-10 2004 Moreover, GC-MS analysis indicated a significantly increased production of epoxyeicosatrienoic acids, vasodilator metabolites of CYP/epoxygenase, in arterioles incubated with 17beta-E2, a response that was prevented by ICI 182780 and wortmannin, respectively. epoxyeicosatrienoic acids 75-100 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 129-132 12016269-2 2002 The epoxyeicosatrienoic acids (EETs), which are products of cytochrome P450 (CYP) epoxygenases, possess vasodilatory, antiinflammatory, and fibrinolytic properties. epoxyeicosatrienoic acids 4-29 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 60-75 12939236-2 2003 Renal cytochrome P450 (CYP)-derived eicosanoids--hydroxyeicosatetraenoic acids (HETEs), epoxyeicosatrienoic acids (EETs), and dihydroxyeicosatrienoic acids (DHETs)--have been shown to play an important role in the regulation of renal function, vascular tone, and blood pressure. epoxyeicosatrienoic acids 88-113 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 6-21 12939236-2 2003 Renal cytochrome P450 (CYP)-derived eicosanoids--hydroxyeicosatetraenoic acids (HETEs), epoxyeicosatrienoic acids (EETs), and dihydroxyeicosatrienoic acids (DHETs)--have been shown to play an important role in the regulation of renal function, vascular tone, and blood pressure. epoxyeicosatrienoic acids 88-113 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 23-26 12975498-1 2003 Cytochrome P450 (P450)-dependent metabolites of arachidonic acid, the epoxyeicosatrienoic acids (EETs), are proposed to be endothelium-derived hyperpolarizing factors (EDHF) that affect vascular tone; however, the effects of EDHF on endothelial-derived nitric oxide biosynthesis remain unknown. epoxyeicosatrienoic acids 70-95 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 0-21 12623785-2 2003 We hypothesized that increased production of arachidonic acid metabolites such as the cyclooxygenase product prostacyclin or cytochrome p-450 (CYP) epoxygenase-derived epoxyeicosatrienoic acids (EETs) contributes to VSM cell hyperpolarization following CH. epoxyeicosatrienoic acids 168-193 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 125-141 12623785-2 2003 We hypothesized that increased production of arachidonic acid metabolites such as the cyclooxygenase product prostacyclin or cytochrome p-450 (CYP) epoxygenase-derived epoxyeicosatrienoic acids (EETs) contributes to VSM cell hyperpolarization following CH. epoxyeicosatrienoic acids 168-193 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 143-146 10779386-1 2000 Epoxyeicosatrienoic acids (EETs) are major products of cytochrome P450 (CYP)-catalyzed metabolism of arachidonic acid in the kidney. epoxyeicosatrienoic acids 0-25 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 55-70 11071299-2 2000 Arachidonic acid (AA) is metabolized by cytochrome P450 (CYP)-dependent pathways to epoxyeicosatrienoic acids (EET) and 20-hydroxyeicosatetraenoic acid (20-HETE) in the kidney and the peripheral vasculature. epoxyeicosatrienoic acids 84-109 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 40-55 11071299-2 2000 Arachidonic acid (AA) is metabolized by cytochrome P450 (CYP)-dependent pathways to epoxyeicosatrienoic acids (EET) and 20-hydroxyeicosatetraenoic acid (20-HETE) in the kidney and the peripheral vasculature. epoxyeicosatrienoic acids 84-109 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 57-60 10779386-1 2000 Epoxyeicosatrienoic acids (EETs) are major products of cytochrome P450 (CYP)-catalyzed metabolism of arachidonic acid in the kidney. epoxyeicosatrienoic acids 0-25 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 72-75