PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10882396-7 2000 [(3)H]-Spiperone labelled a single, lower affinity site in HEK293 cells expressing h5-HT(1A) receptors but did not bind to native tissue 5-HT(1A) receptors. Spiperone 7-16 5-hydroxytryptamine receptor 1A Homo sapiens 84-91 30347827-16 2018 Docking studies showed that S14506, buspirone and spiperone bind in similar ways in the 5-HT1A receptor model and interacted with similar 5-HT1A receptor residues. Spiperone 50-59 5-hydroxytryptamine receptor 1A Homo sapiens 88-103 30347827-16 2018 Docking studies showed that S14506, buspirone and spiperone bind in similar ways in the 5-HT1A receptor model and interacted with similar 5-HT1A receptor residues. Spiperone 50-59 5-hydroxytryptamine receptor 1A Homo sapiens 138-153 12052193-5 2002 Replacement of the N(1)-phenyl ring of spiperone with a methyl group (KML-010; 48) resulted in a compound that binds at 5-HT(2A) receptors with slightly lower affinity than spiperone, but that lacked affinity (Ki >10,000 nM) for 5-HT(2C) and 5-HT(1A) receptors and binds with 400-fold reduced affinity at D2 receptors. Spiperone 39-48 5-hydroxytryptamine receptor 1A Homo sapiens 245-252 12503636-0 2002 Nad-299 antagonises 5-HT-stimulated and spiperone-inhibited [35S]GTPgammaS binding in cloned 5-HT1A receptors. Spiperone 40-49 5-hydroxytryptamine receptor 1A Homo sapiens 93-99 11961140-1 2002 Fusion proteins between the human 5-hydroxytryptamine (5-HT)(1A) receptor and either wild type or certain pertussis toxin-resistant forms of G(o1)alpha and G(i1)alpha display constitutive GTPase activity that can be inhibited by the inverse agonist spiperone. Spiperone 249-258 5-hydroxytryptamine receptor 1A Homo sapiens 34-73 9402034-8 1997 Each of the [35S]GTP gamma S binding responses was mediated by a 5-HT1A receptor as indicated by the competitive blockade by WAY100635 and spiperone. Spiperone 139-148 5-hydroxytryptamine receptor 1A Homo sapiens 65-80 10496950-4 1999 Spiperone functioned as an inverse agonist in membranes expressing the 5-HT(1A) receptor wild-type G(i1)alpha fusion protein and in those expressing 5-HT(1A) receptor (Ile(351))G(i1)alpha but not the 5-HT(1A) receptor (Gly(351))G(i1)alpha fusion protein. Spiperone 0-9 5-hydroxytryptamine receptor 1A Homo sapiens 71-88 10496950-4 1999 Spiperone functioned as an inverse agonist in membranes expressing the 5-HT(1A) receptor wild-type G(i1)alpha fusion protein and in those expressing 5-HT(1A) receptor (Ile(351))G(i1)alpha but not the 5-HT(1A) receptor (Gly(351))G(i1)alpha fusion protein. Spiperone 0-9 5-hydroxytryptamine receptor 1A Homo sapiens 149-166 10496950-4 1999 Spiperone functioned as an inverse agonist in membranes expressing the 5-HT(1A) receptor wild-type G(i1)alpha fusion protein and in those expressing 5-HT(1A) receptor (Ile(351))G(i1)alpha but not the 5-HT(1A) receptor (Gly(351))G(i1)alpha fusion protein. Spiperone 0-9 5-hydroxytryptamine receptor 1A Homo sapiens 149-166 10496950-5 1999 The effect of spiperone at the 5-HT(1A) receptor wild-type G(i1)alpha construct but not the 5-HT(1A) receptor (Ile(351))G(i1)alpha construct was blocked by pertussis toxin treatment. Spiperone 14-23 5-hydroxytryptamine receptor 1A Homo sapiens 31-48 9176059-6 1997 The antagonists ketanserin, methysergide and spiperone attenuated the action of serotonin, while yohimbine and spiroxatrine were ineffectual, thus indicating that the potentiating effect was through the 5-HT1A receptor. Spiperone 45-54 5-hydroxytryptamine receptor 1A Homo sapiens 203-209 9138675-0 1997 Inhibition of the constitutive activity of human 5-HT1A receptors by the inverse agonist, spiperone but not the neutral antagonist, WAY 100,635. Spiperone 90-99 5-hydroxytryptamine receptor 1A Homo sapiens 49-55 9138675-2 1997 In contrast, spiperone inhibited basal [35S]-GTP gamma S binding by 30.2% (IC50 = 55.5 nM) in CHO-5-HT1A membranes but not in control untransfected membranes. Spiperone 13-22 5-hydroxytryptamine receptor 1A Homo sapiens 98-104 9016944-6 1996 Indeed, both GR127935 and the 5-HT1A antagonist spiperone shift the EC50 for the residual effect of 5-HT from approximately 300 to 120-150 nM, suggesting that blocking one receptor subtype may facilitate activation of the other. Spiperone 48-57 5-hydroxytryptamine receptor 1A Homo sapiens 30-36 8566173-4 1995 The 5-HT1A receptor antagonists spiperone and SDZ 216-525 completely abolished the effect of 8-OH-DPAT (IC50 30 nM for both drugs) behaving as pure antagonists. Spiperone 32-41 5-hydroxytryptamine receptor 1A Homo sapiens 4-19 8979820-6 1996 In recordings of superficial layer neurons from SC slices, application of 5-HT during blockade of 5-HT1A receptors with spiperone reduced the amplitude of EPSPs evoked by stimulation of the optic tract. Spiperone 120-129 5-hydroxytryptamine receptor 1A Homo sapiens 98-104 1403796-9 1992 The selective 5-HT1A antagonist BMY 7378 and the 5-HT1A/2 antagonist spiperone were competitive in area CA1, but insurmountable in area CA3. Spiperone 69-78 5-hydroxytryptamine receptor 1A Homo sapiens 49-55 7671319-5 1995 Spiperone and NAN-190, antagonists to 5-HT1A receptor subtype, abolished the serotonin effects on calcium signaling, whereas an agonist to 5-HT1A receptor, 8OHDPAT, mimicked the serotonin-like action on the diminution of the intracellular calcium contents. Spiperone 0-9 5-hydroxytryptamine receptor 1A Homo sapiens 38-53 8461029-4 1993 For both radioligands the binding sites labelled have the properties of 5HT1A receptors and most antagonists show roughly equal affinities for the receptors labelled by either [3H]8-OH-DPAT or [3H]spiperone. Spiperone 197-206 5-hydroxytryptamine receptor 1A Homo sapiens 72-77 7620887-5 1995 The effects of all agonists were completely or partially blocked by the 5-HT1A and 5-HT2 receptor antagonist spiperone (spiroperidol hydrochloride) while selective 5-HT2 receptor antagonists were ineffective. Spiperone 109-118 5-hydroxytryptamine receptor 1A Homo sapiens 72-97 2178032-4 1990 The effects of ipsapirone were reversed by the 5-HT1A antagonist spiperone. Spiperone 65-74 5-hydroxytryptamine receptor 1A Homo sapiens 47-53 1446239-11 1992 This response, as well as the 5HT mediated suppression are blocked by the application of spiperone, a 5HT1A antagonist. Spiperone 89-98 5-hydroxytryptamine receptor 1A Homo sapiens 102-107 1320445-9 1992 The 5-HT1C/2 antagonist ketanserin and the 5-HT1A/2 antagonist spiperone significantly attenuated the 5-HT-induced depression of NMDA-depolarizations. Spiperone 63-72 5-hydroxytryptamine receptor 1A Homo sapiens 43-49 1683291-6 1991 administration of the 5HT1A receptor antagonist spiperone. Spiperone 48-57 5-hydroxytryptamine receptor 1A Homo sapiens 22-36 1683291-7 1991 Similarly we have previously observed spiperone reversal of the sympatholytic effects of the 5-HT1A agonist 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin) but failed to affect nerve activity when given alone. Spiperone 38-47 5-hydroxytryptamine receptor 1A Homo sapiens 93-99 2969339-7 1988 It is concluded that spiperone is an antagonist of 5-HT1A receptors in the dorsal raphe nucleus. Spiperone 21-30 5-hydroxytryptamine receptor 1A Homo sapiens 51-57 2138222-4 1990 8-OH-DPAT (0.0625-4.0 micrograms) produced dose-dependent hypotension and bradycardia, which were antagonized by the 5-HT1A antagonists spiperone and spiroxatrine. Spiperone 136-145 5-hydroxytryptamine receptor 1A Homo sapiens 117-123 2141111-6 1990 The changes in potential produced by low concentrations of serotonin and by these agonists were blocked by the 5-HT1A receptor antagonists spiperone and spiroxatrine. Spiperone 139-148 5-hydroxytryptamine receptor 1A Homo sapiens 111-126 2969339-0 1988 Electrophysiological evidence that spiperone is an antagonist of 5-HT1A receptors in the dorsal raphe nucleus. Spiperone 35-44 5-hydroxytryptamine receptor 1A Homo sapiens 65-71 2969339-1 1988 The neuroleptic spiperone, which binds to 5-HT1A, 5-HT2 and dopamine (DA) receptors, was studied for its effects on serotonin (5-HT) and DA neurons in dorsal raphe nucleus and substantia nigra pars compacta, respectively. Spiperone 16-25 5-hydroxytryptamine receptor 1A Homo sapiens 42-48 2969339-3 1988 spiperone, but not LY53837 (a 5-HT2 antagonist), antagonized the inhibition induced by 5-HT1A agonists 8-hydroxy-dipropylaminotetralin (8-OH-DPAT) and buspirone in the dorsal raphe nucleus. Spiperone 0-9 5-hydroxytryptamine receptor 1A Homo sapiens 87-93