PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10211591-3	1999	The effect of either 5-HT or DOI is blocked by selective 5-HT2A receptor antagonists such as spiperone and ketanserin and more markedly by mixed 5-HT2 receptor antagonists, such as ritanserin, methysergide and mesulergine, with higher affinity at the 2C subtype.	Spiperone	93-102	5-hydroxytryptamine receptor 2A	Rattus norvegicus	57-63	
9836624-0	1998	Spiperone: influence of spiro ring substituents on 5-HT2A serotonin receptor binding.	Spiperone	0-9	5-hydroxytryptamine receptor 2A	Rattus norvegicus	51-57	
9836624-7	1998	As such, N1-alkyl analogues of spiperone may afford entry into a novel series of 5-HT2A-selective antagonists.	Spiperone	31-40	5-hydroxytryptamine receptor 2A	Rattus norvegicus	81-87	
9836624-1	1998	Spiperone (1) is a widely used pharmacological tool that acts as a potent dopamine D2, serotonin 5-HT1A, and serotonin 5-HT2A antagonist.	Spiperone	0-9	5-hydroxytryptamine receptor 2A	Rattus norvegicus	119-125	
8684602-7	1996	The pain response produced by alpha-methyl-5-HT plus PGE2 was blocked by pretreatment with the 5-HT2A/2C antagonists ketanserin and ritanserin, and the 5-HT2A antagonist spiperone (MPE50 values 1.4, 7.7 and 0.06 nmol, respectively).	Spiperone	170-179	5-hydroxytryptamine receptor 2A	Rattus norvegicus	152-158	
9326273-7	1997	In contrast to that in caudate, PLC activity in frontal cortex was stimulated by 5-HT in a manner that was inhibited by the 5-HT2A-selective antagonists, spiperone and ketanserin.	Spiperone	154-163	5-hydroxytryptamine receptor 2A	Rattus norvegicus	124-130	
7898773-4	1994	5-HT2A receptors: risperidone (9.07) > spiperone > chlorpromazine > clozapine > thioridazine = fluphenazine > haloperidol (6.03).	Spiperone	42-51	5-hydroxytryptamine receptor 2A	Rattus norvegicus	0-6	
7620898-3	1995	Spiperone and MDL 100,507, antagonists that bind with 300- to 1000-fold higher affinity to 5-HT2A receptors, blocked 5-HT-induced phosphoinositide hydrolysis in hippocampi of 7-day-old, but not 21-day-old, rats.	Spiperone	0-9	5-hydroxytryptamine receptor 2A	Rattus norvegicus	91-97	
7996480-5	1994	Because spiperone has a higher affinity for 5-HT2A than 5-HT2C receptors, these data suggest that DOI stimulates ACTH secretion through 5-HT2A receptors.	Spiperone	8-17	5-hydroxytryptamine receptor 2A	Rattus norvegicus	44-50	
7996480-5	1994	Because spiperone has a higher affinity for 5-HT2A than 5-HT2C receptors, these data suggest that DOI stimulates ACTH secretion through 5-HT2A receptors.	Spiperone	8-17	5-hydroxytryptamine receptor 2A	Rattus norvegicus	136-142	
6136009-1	1983	The effect of beta-adrenoceptor agonists and antagonists on the binding of [3H]-spiperone in the frontal cortex of the rat has been examined to determine their possible interaction with the 5-hydroxytryptamine2 (5-HT2) receptor.	Spiperone	75-89	5-hydroxytryptamine receptor 2A	Rattus norvegicus	212-217	
7965707-4	1994	On the other hand, spiperone (5-HT1A/5-HT2A/D2 antagonist) pretreatment significantly attenuated DOM-induced increases in ACTH but not corticosterone.	Spiperone	19-28	5-hydroxytryptamine receptor 2A	Rattus norvegicus	37-43	
7981639-3	1994	Spiperone (1 microM) and sulpiride (1 microM) were used to displace [125I]LSD binding from 5-HT2A and D2 binding sites, respectively.	Spiperone	0-9	5-hydroxytryptamine receptor 2A	Rattus norvegicus	91-97	
8035308-6	1994	On the other hand, spiperone (5-HT1A/5-HT2A/D2 antagonist) pretreatment significantly attenuated DOM-induced hyperthermia but accentuated DOM-induced hypophagia.	Spiperone	19-28	5-hydroxytryptamine receptor 2A	Rattus norvegicus	37-43	
2243353-1	1990	The 5-HT2 (serotonin) receptor has traditionally been labeled with antagonist radioligands such as [3H]ketanserin and [3H]spiperone, which label both agonist high-affinity (guanyl nucleotide-sensitive) and agonist low-affinity (guanyl nucleotide-insensitive) states of this receptor.	Spiperone	122-131	5-hydroxytryptamine receptor 2A	Rattus norvegicus	4-30