PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18987251-8	2009	Spiperone activates CaCCs, which stimulates Cl(-) secretion in polarized human non-CF and CF airway epithelial cell monolayers in vitro and in CFTR-knockout mice in vivo.	Spiperone	0-9	CF transmembrane conductance regulator	Homo sapiens	143-147	
21765932-4	2011	Our previous study has shown that spiperone, a known antipsychotic drug, activates CaCCs and stimulates Cl(-) secretion in polarized human non-CF and CF airway epithelial cell monolayers in vitro, and in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) knockout mice in vivo.	Spiperone	34-43	CF transmembrane conductance regulator	Homo sapiens	204-255	
21765932-4	2011	Our previous study has shown that spiperone, a known antipsychotic drug, activates CaCCs and stimulates Cl(-) secretion in polarized human non-CF and CF airway epithelial cell monolayers in vitro, and in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) knockout mice in vivo.	Spiperone	34-43	CF transmembrane conductance regulator	Homo sapiens	257-261	
21765932-6	2011	Moreover, spiperone independently activates CFTR through a novel mechanism.	Spiperone	10-19	CF transmembrane conductance regulator	Homo sapiens	44-48	
21765932-7	2011	Herein, we performed a mass spectrometry analysis and identified the signaling molecule that mediates the spiperone effect in activating chloride secretion through CaCC and CFTR.	Spiperone	106-115	CF transmembrane conductance regulator	Homo sapiens	173-177	
21765932-10	2011	In conclusion, we have identified the tyrosine kinase, PYK2, as the modulator, which plays a crucial role in the activation of CaCC and CFTR by spiperone.	Spiperone	144-153	CF transmembrane conductance regulator	Homo sapiens	136-140