PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17272831-3	2007	Mevalonic acid, the product of HMG-CoA reductase, was converted to mevalonolactone (MVL) in an incubation mixture, extracted by a salting-out procedure, derivatized into the mevalonyl-(2-pyrrolidin-1-yl-ethyl)-amide, and then purified using a disposable silica cartridge.	mevalonolactone	67-82	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	31-48	
12871602-11	2003	Concurrent treatment with mevalonolactone prevented the induction of apoptosis and suppressed both IL-1beta and IL-1Ra release in response to LPS, suggesting a rate-limiting role for HMG-CoA reductase in monocyte differentiation.	mevalonolactone	26-41	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	183-200	
3004340-0	1986	Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts by reversible phosphorylation: modulation of enzymatic activity by low density lipoprotein, sterols, and mevalonolactone.	mevalonolactone	197-212	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	14-61	
24333427-1	2014	Hydroxymethylglutaryl coenzyme A reductase (HMGCR) catalyzes the rate limiting step in cholesterol biosynthesis converting HMG-CoA into mevalonic acid (MVA), which equilibrates with mevalonic acid lactone (MVL) under neutral pH conditions.	mevalonolactone	182-204	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	0-42	
24333427-1	2014	Hydroxymethylglutaryl coenzyme A reductase (HMGCR) catalyzes the rate limiting step in cholesterol biosynthesis converting HMG-CoA into mevalonic acid (MVA), which equilibrates with mevalonic acid lactone (MVL) under neutral pH conditions.	mevalonolactone	182-204	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	44-49	
3042028-8	1988	Preincubation of cells with 2.5-10 mM mevalonolactone decreased the incorporation of [14C]acetate into cholesterol 6.2-fold, indicating an inhibitory effect on HMG-CoA reductase.	mevalonolactone	38-53	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	160-177	
263339-3	1978	The activity of HMG CoA reductase was expressed as nanomoles of mevalonolactone formed/min .	mevalonolactone	64-79	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	16-33	
30899443-6	2019	Statin toxicity was rescued by addition of exogenous mevalonolactone or geranylgeranyl pyrophosphate, indicating that the observed effects reflected inhibition of HMG CoA-reductase by the statins.	mevalonolactone	53-68	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	163-180