PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 4353083-9 1973 Addition of 15mm-fructose initially decreased glucokinase activity. Fructose 16-25 glucokinase Rattus norvegicus 46-57 2917560-7 1989 It is concluded that the regulator plays a role in the physiological control of the activity of glucokinase, particularly with respect to the stimulatory effect of fructose in isolated hepatocytes (see preceding paper in this journal). Fructose 164-172 glucokinase Rattus norvegicus 96-107 6477520-0 1984 Fructose is a good substrate for rat liver "glucokinase" (hexokinase D). Fructose 0-8 glucokinase Rattus norvegicus 43-55 6477520-0 1984 Fructose is a good substrate for rat liver "glucokinase" (hexokinase D). Fructose 0-8 glucokinase Rattus norvegicus 58-70 6477520-1 1984 Rat liver "glucokinase" (hexokinase D) catalyses the phosphorylation of fructose with a maximal velocity about 2.5-fold higher than that for the phosphorylation of glucose. Fructose 72-80 glucokinase Rattus norvegicus 10-22 6477520-1 1984 Rat liver "glucokinase" (hexokinase D) catalyses the phosphorylation of fructose with a maximal velocity about 2.5-fold higher than that for the phosphorylation of glucose. Fructose 72-80 glucokinase Rattus norvegicus 25-37 6477520-4 1984 Fructose protects hexokinase D against inactivation by 5,5"-dithiobis-(2-nitrobenzoic acid), and the apparent dissociation constants are about 300 mM in the presence of different concentrations of the inhibitor. Fructose 0-8 glucokinase Rattus norvegicus 18-30 6477520-6 1984 Fructose appears to be no better as a substrate for the other mammalian hexokinases than it is for hexokinase D. Fructose 0-8 glucokinase Rattus norvegicus 99-111 4353083-10 1973 Constant infusion of fructose decreased activities of glucokinase, phosphofructokinase, pyruvate carboxylase, phosphoenolpyruvate carboxylase, glucose 6-phosphatase and serine dehydratase. Fructose 21-29 glucokinase Rattus norvegicus 54-65 19794521-0 2009 Regulation of liver glucokinase activity in rats with fructose-induced insulin resistance and impaired glucose and lipid metabolism. Fructose 54-62 glucokinase Rattus norvegicus 20-31 32070154-3 2020 High-fructose diet led to hyperinsulinemia, increased glucose transporter 2 level, elevated protein kinase B (Akt) phosphorylation, increased glucokinase mRNA and phospho-to-total glycogen synthase kinase 3 ratio and decreased expression of gluconeogenic genes. Fructose 5-13 glucokinase Rattus norvegicus 142-153 26524624-1 2015 We tested the exendin-4 and des-fluoro-sitagliptin effects on fructose-induced increase in liver glucokinase activity in rats with impaired glucose tolerance and the exendin-4 effect on glucokinase activity in HepG2 cells incubated with fructose in the presence/absence of exendin-9-39. Fructose 62-70 glucokinase Rattus norvegicus 97-108 26524624-3 2015 Fructose fed rats had: hypertriglyceridemia, hyperinsulinemia and high liver glucokinase activity (mainly located in the cytosolic fraction) together with higher glucokinase and 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase mRNA and protein concentrations compared to control rats. Fructose 0-8 glucokinase Rattus norvegicus 77-88 26524624-3 2015 Fructose fed rats had: hypertriglyceridemia, hyperinsulinemia and high liver glucokinase activity (mainly located in the cytosolic fraction) together with higher glucokinase and 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase mRNA and protein concentrations compared to control rats. Fructose 0-8 glucokinase Rattus norvegicus 162-173 24361606-9 2014 Fructose fed rats showed increased fructokinase gene expression, protein content and activity, glucokinase and glucose-6-phosphatase gene expression and activity, glycogen storage, glucose-6-phosphate dehydrogenase mRNA and enzyme activity, NAD(P)H oxidase subunits (gp91(phox) and p22(phox)) gene expression and protein concentration and phosphofructokinase-2 protein content than control rats. Fructose 0-8 glucokinase Rattus norvegicus 95-106 19794521-8 2009 Results suggest that increased liver GK activity might participate in the adaptative response to fructose overload to maintain glucose/triglyceride homeostasis in intact animals. Fructose 97-105 glucokinase Rattus norvegicus 37-39 9376178-7 1997 Lower concentrations (0.05-5 mM) of fructose, which is known to stimulate glucose phosphorylation by GK, in combination with 5 mM glucose, induced the translocation of GK from the nucleus to the cytoplasm. Fructose 36-44 glucokinase Rattus norvegicus 101-103 10989935-3 2000 Higher concentrations of glucose, 5 mM glucose plus 1 mM fructose, and 5 mM glucose plus 1 mM sorbitol all induced the translocation of glucokinase from the nucleus to the cytoplasm in hepatocytes from these rats. Fructose 57-65 glucokinase Rattus norvegicus 136-147 18812575-6 2008 Likewise, both fructose (converted intracellularly into fructose-1-phosphate) and a known allosteric GK activator were found to induce the export of GK from the nucleus and to synergistically enhance the effects of medium or high glucose concentrations with respect to GK translocation. Fructose 15-23 glucokinase Rattus norvegicus 149-151 18812575-6 2008 Likewise, both fructose (converted intracellularly into fructose-1-phosphate) and a known allosteric GK activator were found to induce the export of GK from the nucleus and to synergistically enhance the effects of medium or high glucose concentrations with respect to GK translocation. Fructose 15-23 glucokinase Rattus norvegicus 149-151 12964028-1 2003 It was recently reported that alpha-D-glucose is more potent than beta-D-glucose in conferring to glucokinase positive cooperativity towards D-fructose. Fructose 141-151 glucokinase Rattus norvegicus 98-109 12964028-5 2003 These findings indicate that the anomeric specificity of the effect of D-glucose upon D-fructose phosphorylation by glucokinase is also operative in intact islets. Fructose 86-96 glucokinase Rattus norvegicus 116-127 11456280-3 2001 The addition of low concentrations of fructose, which is known to stimulate glucose phosphorylation, stimulated both glucokinase translocation and glucose phosphorylation. Fructose 38-46 glucokinase Rattus norvegicus 117-128 11456280-4 2001 There was a good correlation between the increase in cytoplasmic glucokinase induced by fructose and that in the glucose phosphorylation rate induced by fructose. Fructose 88-96 glucokinase Rattus norvegicus 65-76 11456280-4 2001 There was a good correlation between the increase in cytoplasmic glucokinase induced by fructose and that in the glucose phosphorylation rate induced by fructose. Fructose 153-161 glucokinase Rattus norvegicus 65-76 11456280-7 2001 Also, oral administration of glucose, fructose, or glucose plus fructose to 24-h fasted rats induced translocation of glucokinase in the liver. Fructose 38-46 glucokinase Rattus norvegicus 118-129 9726598-8 1998 In hepatocytes in primary culture, mannitol decreased the detritiation rate and counteracted the effect of fructose to stimulate glucokinase translocation. Fructose 107-115 glucokinase Rattus norvegicus 129-140 9376178-7 1997 Lower concentrations (0.05-5 mM) of fructose, which is known to stimulate glucose phosphorylation by GK, in combination with 5 mM glucose, induced the translocation of GK from the nucleus to the cytoplasm. Fructose 36-44 glucokinase Rattus norvegicus 168-170 9003425-2 1997 In hepatocytes in primary culture, fructose was metabolized at approximately one-quarter of the rate of sorbitol, and was therefore much less potent than the polyol in increasing the concentration of fructose 1-phosphate and the translocation of glucokinase. Fructose 35-43 glucokinase Rattus norvegicus 246-257 9003425-0 1997 Investigation on the mechanism by which fructose, hexitols and other compounds regulate the translocation of glucokinase in rat hepatocytes. Fructose 40-48 glucokinase Rattus norvegicus 109-120 9003425-3 1997 In cultures, sorbitol, commercial mannitol, fructose, D-glyceraldehyde or high concentrations of glucose caused fructose 1-phosphate formation and glucokinase translocation in parallel. Fructose 44-52 glucokinase Rattus norvegicus 147-158 8129726-3 1994 giving half-maximal activation (A50) 15 mM] or with fructose (A50 50 microM) causes translocation of glucokinase from its Mg(2+)-dependent binding site to an alternative site [Agius and Peak (1993) Biochem. Fructose 52-60 glucokinase Rattus norvegicus 101-112 8144600-6 1994 In hepatocytes, fructose in low concentrations is phosphorylated into fructose 1-phosphate, and therefore is able to active GK in the absence of insulin via the regulatory protein in the liver. Fructose 16-24 glucokinase Rattus norvegicus 124-126 8144600-10 1994 In the presence of glucose, the L-PK promoter can also be activated by a post-translational GK activation, mediated by a low concentration of fructose acting via the regulatory protein of glucokinase. Fructose 142-150 glucokinase Rattus norvegicus 92-94 8144600-10 1994 In the presence of glucose, the L-PK promoter can also be activated by a post-translational GK activation, mediated by a low concentration of fructose acting via the regulatory protein of glucokinase. Fructose 142-150 glucokinase Rattus norvegicus 188-199 8129726-6 1994 A comparison of various substrates showed that sorbitol (A50 8 microM) was 6-fold more potent than fructose at causing glucokinase translocation, whereas tagatose was as potent and mannitol was > 10-fold less potent (A50 550 microM). Fructose 99-107 glucokinase Rattus norvegicus 119-130 8129726-8 1994 Ethanol and glycerol inhibited the effects of fructose, sorbitol and glucose on glucokinase translocation, whereas dihydroxy-acetone had a small additive effect at sub-maximal substrate stimulation. Fructose 46-54 glucokinase Rattus norvegicus 80-91