PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16238186-0 2005 Leptin response to oral glucose tolerance test in obese and nonobese premenopausal women. Glucose 24-31 leptin Homo sapiens 0-6 16238186-1 2005 The objective of this study was to investigate the serum leptin response to oral glucose stimulation in a group of obese and nonobese normotensive, normolipidemic, and glucose-tolerant premenopausal women. Glucose 81-88 leptin Homo sapiens 57-63 15660870-9 2004 Gender difference of linking of leptin with glucose or lipid was observed. Glucose 44-51 leptin Homo sapiens 32-38 15858242-5 2004 OBJECTIVES: The aim of the present study was to evaluate leptin levels after delivery in GDM and normal glucose tolerance (NGT) women. Glucose 104-111 leptin Homo sapiens 57-63 15181973-6 2004 Abnormalities in serum leptin concentrations have recently been linked with deleterious effects on weight control, cardiovascular health and glucose regulation. Glucose 141-148 leptin Homo sapiens 23-29 15181085-1 2004 Previous studies indicate that leptin secretion is regulated by insulin-mediated glucose metabolism. Glucose 81-88 leptin Homo sapiens 31-37 15219792-6 2004 Leptin mRNA expression in subcutaneous tissue was independently correlated with fasting glucose (R = 0.89, P < 0.006) at premenopause, and with serum estradiol (R = 0.77, P < 0.04) at postmenopause. Glucose 88-95 leptin Homo sapiens 0-6 15072562-4 2004 Leptin, a hormone linking adiposity and central nervous circuits to reduce appetite and enhance energy expenditure, has been shown to increase overall sympathetic nerve activity, facilitate glucose utilization and improve insulin sensitivity. Glucose 190-197 leptin Homo sapiens 0-6 15052530-3 2004 In the present study, we evaluated serum ghrelin and bound leptin levels in patients with primary biliary cirrhosis (PBC) in relation to C-peptide and glucose concentration. Glucose 151-158 leptin Homo sapiens 59-65 14749281-7 2004 The molecular effects of leptin culminate to restrict insulin secretion and biosynthesis to adapt glucose homeostasis to the amount of body fat. Glucose 98-105 leptin Homo sapiens 25-31 12788860-6 2003 The low serum leptin level on admission in subjects with hyperglycemic crises may be the result of impaired adipocyte glucose utilization due to insulin deficiency and/or to increased catecholamine levels. Glucose 118-125 leptin Homo sapiens 14-20 12959967-7 2003 These studies provide evidence that fetal glucose and insulin differentially regulate fetal fat deposition and leptin mRNA expression within the fetal perirenal fat depot in the well nourished animal during late gestation. Glucose 42-49 leptin Homo sapiens 111-117 14602749-13 2003 It is likely that the reductions in ghrelin and leptin reflect the metabolic effects of GH on lipid mobilization and glucose production. Glucose 117-124 leptin Homo sapiens 48-54 12906034-7 2003 On univariate correlation analysis, leptin showed the strongest association with BMI in both sexes and also correlated significantly with BMI, insulin, uric acid, glucose, total cholesterol, and triglycerides in males and BMI, insulin, uric acid, total cholesterol, apo B, and creatinine in females after adjustment for age and BMI. Glucose 163-170 leptin Homo sapiens 36-42 12880566-0 2003 [Relationship between serum levels of leptin and glucose, lipids in simple obese children]. Glucose 49-56 leptin Homo sapiens 38-44 12657513-0 2003 Leptin induces mitogenic effect on human choriocarcinoma cell line (JAr) via MAP kinase activation in a glucose-dependent fashion. Glucose 104-111 leptin Homo sapiens 0-6 12895305-0 2003 [Maternal plasma leptin levels and their relationship to insulin and glucose in pregnant women with gestational diabetes mellitus and gestational impaired glucose tolerance]. Glucose 69-76 leptin Homo sapiens 17-23 12895305-2 2003 METHODS: Radio immunoassay was used to measure the leptin levels at fasting and 3 h after oral glucose load (50 g) in 36 patients with GDM and GIGT, and also in 24 normal pregnant women. Glucose 95-102 leptin Homo sapiens 51-57 12895305-7 2003 A positive correlation was also found between maternal leptin concentrations and glycosylated haemoglobin values, as well as between leptin levels and plasma glucose levels obtained 1 h after the administration of 50g glucose in women with GDM and GIGT (r = 0.758, P < 0.01; r = 0.561, P < 0.01). Glucose 158-165 leptin Homo sapiens 133-139 12895305-7 2003 A positive correlation was also found between maternal leptin concentrations and glycosylated haemoglobin values, as well as between leptin levels and plasma glucose levels obtained 1 h after the administration of 50g glucose in women with GDM and GIGT (r = 0.758, P < 0.01; r = 0.561, P < 0.01). Glucose 218-225 leptin Homo sapiens 133-139 12895305-8 2003 CONCLUSIONS: Leptin levels are elevated in pregnant women with GDM and GIGT compared with healthy pregnant women, a positive and significant correlation was found between the maternal leptin levels and fasting insulin levels, as well as between the maternal leptin levels and plasma glucose levels obtained 1 h after the administration of 50 g glucose in women with GDM and GIGT. Glucose 283-290 leptin Homo sapiens 13-19 12895305-8 2003 CONCLUSIONS: Leptin levels are elevated in pregnant women with GDM and GIGT compared with healthy pregnant women, a positive and significant correlation was found between the maternal leptin levels and fasting insulin levels, as well as between the maternal leptin levels and plasma glucose levels obtained 1 h after the administration of 50 g glucose in women with GDM and GIGT. Glucose 344-351 leptin Homo sapiens 13-19 12679437-7 2003 Across a spectrum of subjects with diabetes, impaired fasting glucose/mild diabetes, or BMI-matched nondiabetic controls, normalized leptin significantly correlated with glucose-induced insulin release, but not with insulin sensitivity. Glucose 62-69 leptin Homo sapiens 133-139 12657513-3 2003 At variance, at 25m M glucose (HG), proliferation and thymidine incorporation were stimulated by leptin and serum to a comparable extent. Glucose 22-29 leptin Homo sapiens 97-103 12657513-8 2003 In this study, we provide evidence that in placental cells, leptin, similarly to that observed with insulin, stimulates cell proliferation by inducing the IRS1/MAPK pathway in a glucose-dependent fashion. Glucose 178-185 leptin Homo sapiens 60-66 12502655-8 2003 Insulin stimulated glucose uptake during 60-120 min of the euglycemic clamp studies, and the rate of glucose disappearance during the insulin tolerance test nearly doubled with leptin therapy. Glucose 101-108 leptin Homo sapiens 177-183 12614978-9 2003 Although obesity is associated with type 2 diabetes mellitus, patients may have decreased leptin levels, especially when glucose is poorly controlled. Glucose 121-128 leptin Homo sapiens 90-96 12582201-1 2003 Leptin, initially identified as a hormone produced by white fat that acted as a satiety signal, has since been found to be synthesized in various tissues and to subserve diverse functions, including regulation of blood glucose concentrations and blood vessel growth, and signaling to the reproductive and immune systems. Glucose 219-226 leptin Homo sapiens 0-6 14614228-7 2003 Flutamide treatment led to increased leptin levels and leptin responses to oral glucose tolerance tests in PCOS patients. Glucose 80-87 leptin Homo sapiens 55-61 12357293-9 2002 At univariate analysis, fasting leptin level significantly and positively correlated with BMI (r=0.49, p=0.02) and with fasting insulin (r=0.69, p=0.001), while it negatively correlated with the glucose disposal rate (r=-0.62, p=0.002). Glucose 195-202 leptin Homo sapiens 32-38 12468413-6 2002 There are data to indicate that peripheral leptin also modulates glucose metabolism and insulin action; however, its precise role in controlling gluco-regulatory pathways remains uncertain and requires further investigation. Glucose 65-72 leptin Homo sapiens 43-49 12388920-3 2002 Our objective was to investigate serum leptin in acromegaly in terms of disease activity, body fat content, insulin and glucose levels, and selected anthropometric variables. Glucose 120-127 leptin Homo sapiens 39-45 12226021-11 2002 Leptin concentrations correlated with AHI and with biochemical markers of the metabolic syndrome (lipoproteins, glucose) but were not dependent on AHI. Glucose 112-119 leptin Homo sapiens 0-6 12194643-6 2002 The plasma levels of leptin were negatively correlated with mean glucose infusion rate (r = -0.67, p < 0.01). Glucose 65-72 leptin Homo sapiens 21-27 12039705-13 2002 Conversely, the administration of a pulse of insulin and glucose, in the absence of dexamethasone, prevented the drop in serum leptin observed during fasting, regardless of the insulin dose or the serum glucose elevation. Glucose 57-64 leptin Homo sapiens 127-133 12039705-15 2002 A single pulse of insulin with glucose can prevent the drop in serum leptin normally observed during fasting. Glucose 31-38 leptin Homo sapiens 69-75 12021250-3 2002 Here we show that chronic leptin treatment improves insulin-stimulated hepatic and peripheral glucose metabolism in severely insulin-resistant lipodystrophic patients. Glucose 94-101 leptin Homo sapiens 26-32 12061197-15 2002 The decrease in leptin may signal a reduction in body weight after replacing glucose in dialysis solutions with icodextrin, or enhanced rates of leptin elimination as a result of ultrafiltration-induced convective transport. Glucose 77-84 leptin Homo sapiens 16-22 11928535-1 2002 Leptin, identified in 1994 as a substance synthesized in adipose tissue in amounts that are proportional to the magnitude of fat reserves, has been described as an important factor in the regulation of the body"s energy homeostasis as it is capable of inhibiting intake, stimulating energy expenditure and regulating other peripheral metabolic processes involved in the control of the spread of body fat (secretion of insulin, lipolysis, glucose transport). Glucose 438-445 leptin Homo sapiens 0-6 12003376-6 2002 Fasting serum leptin levels were higher in women (16.7 + 11.6 ng/mL) than in men (3.0 +/- 1.5 ng/mL; P < 0.05) and were independent of exogenous insulin intake and of glucose control. Glucose 170-177 leptin Homo sapiens 14-20 12075578-2 2002 However, increasing evidence suggests that insulin-mediated glucose uptake rather than insulin per se regulates circulating leptin concentration. Glucose 60-67 leptin Homo sapiens 124-130 12075578-3 2002 Here, we hypothesised that a reduction of insulin sensitivity, ie insulin resistance, will diminish the stimulatory effect of insulin on leptin secretion as a consequence of decreased insulin-mediated glucose uptake. Glucose 201-208 leptin Homo sapiens 137-143 12075578-12 2002 Across both conditions, the increase of leptin levels during the clamp was correlated with the amount of glucose infused (r = 0.37; P < 0.05). Glucose 105-112 leptin Homo sapiens 40-46 11473954-1 2001 BACKGROUND: Oral and transdermal postmenopausal hormone replacement therapy (HRT) affects lipid and glucose metabolism differently, which is of significance in the release of leptin by adipocytes. Glucose 100-107 leptin Homo sapiens 175-181 11714034-3 2001 induced anorexia accompanied with fever and increases in serum levels of cortisol, insulin and glucose which are known to stimulate leptin secretion in rodent and human, while it did not affect serum leptin levels at all. Glucose 95-102 leptin Homo sapiens 132-138 11457781-8 2001 The increased leptin mass after exercise may have been related to greater plasma glucose concentration during recovery after exercise compared with the control condition. Glucose 81-88 leptin Homo sapiens 14-20 11342529-5 2001 We found that leptin increases ROS generation in BAEC in a dose-dependent manner and that its effects are additive with those of glucose. Glucose 129-136 leptin Homo sapiens 14-20 11797013-2 2002 Leptin stimulates the oxidation of fatty acids and the uptake of glucose, and prevents the accumulation of lipids in nonadipose tissues, which can lead to functional impairments known as "lipotoxicity". Glucose 65-72 leptin Homo sapiens 0-6 11751598-4 2002 Glucose at 5 and 20 mM stimulated leptin release to 759 +/- 227% and 1104 +/- 316% of the control value over the 96-h culture period. Glucose 0-7 leptin Homo sapiens 34-40 11751598-5 2002 Inhibition of hexosamine biosynthesis with 6-diazo-5-oxonorleucine (20 microM) reduced glucose-stimulated leptin release 13 +/- 2.3% and 29.9 +/- 6.6% at 24 and 96 h, respectively (n = 4; P < 0.05). Glucose 87-94 leptin Homo sapiens 106-112 11751598-6 2002 A 24-h incubation in 5 mM glucose significantly increased (163.0 +/- 19.3%; n = 7) the activity of a human LEP promoter electroporated into differentiated 3T3-L1 cells. Glucose 26-33 leptin Homo sapiens 107-110 11751598-11 2002 These data demonstrate that glucose and hexosamines regulate leptin production through transcriptional mechanisms localized to the proximal portion of the LEP promoter. Glucose 28-35 leptin Homo sapiens 61-67 11751598-11 2002 These data demonstrate that glucose and hexosamines regulate leptin production through transcriptional mechanisms localized to the proximal portion of the LEP promoter. Glucose 28-35 leptin Homo sapiens 155-158 11775566-0 2001 Serum leptin levels after bariatric surgery across a range of glucose tolerance from normal to diabetes. Glucose 62-69 leptin Homo sapiens 6-12 11775566-6 2001 Linear univariate analysis for repeated evaluation showed a positive correlation between leptin and glucose, triglycerides, uric acid, and insulin. Glucose 100-107 leptin Homo sapiens 89-95 11564705-6 2001 High glucose (16.7 mM) induced leptin biosynthesis in primary pancreatic islet cells, and the addition of 1 mM palmitate caused an additional incremental effect. Glucose 5-12 leptin Homo sapiens 31-37 11673769-11 2001 The decreased resting leptin concentrations approximately 24 h post-acute exercise may be due to reduced glucose availability to the adipose tissue, particularly in the diabetic subjects. Glucose 105-112 leptin Homo sapiens 22-28 11454513-6 2001 In all patients leptin was significantly related to body mass index, fat mass and the homeostasis model insulin resistance index; moreover we observed a significant relationship with fasting plasma glucose and age in diabetic obese women, and with blood pressure values and testosterone concentrations in diabetic obese men. Glucose 198-205 leptin Homo sapiens 16-22 11454513-7 2001 Multiple regression analysis revealed age and fasting plasma glucose to be the only independent determinants of fasting plasma leptin in diabetic obese women. Glucose 61-68 leptin Homo sapiens 127-133 11454513-10 2001 In the postmenopausal or andropausal status, sex hormones are related to leptin concentrations only in diabetic men; in diabetic women, however, high glucose seems to be relevant in maintaining the same leptin concentrations as in non-diabetic women with similar degree of obesity. Glucose 150-157 leptin Homo sapiens 203-209 11465644-0 2001 Leptin and norepinephrine plasma concentrations during glucose loading in normotensive and hypertensive obese women. Glucose 55-62 leptin Homo sapiens 0-6 11465644-1 2001 We performed this study to investigate whether changes in plasma glucose, insulin, and norepinephrine concentrations during an oral glucose tolerance test (OGTT) are associated with changes in plasma leptin levels in normotensive and hypertensive obese women. Glucose 65-72 leptin Homo sapiens 200-206 11465644-1 2001 We performed this study to investigate whether changes in plasma glucose, insulin, and norepinephrine concentrations during an oral glucose tolerance test (OGTT) are associated with changes in plasma leptin levels in normotensive and hypertensive obese women. Glucose 132-139 leptin Homo sapiens 200-206 11465644-5 2001 Our study confirms that glucose loading increases circulating leptin concentrations in obese women, and demonstrates the existance of an association between leptin and norepinephrine changes during OGTT in both normotensive and hypertensive obese women. Glucose 24-31 leptin Homo sapiens 62-68 11465644-5 2001 Our study confirms that glucose loading increases circulating leptin concentrations in obese women, and demonstrates the existance of an association between leptin and norepinephrine changes during OGTT in both normotensive and hypertensive obese women. Glucose 24-31 leptin Homo sapiens 157-163 11484514-11 2001 The circadian leptin production is delayed in APD patients probably suggesting a negative effect of the nocturnal glucose load on the regulation of its secretion. Glucose 114-121 leptin Homo sapiens 14-20 11353336-7 2001 In addition, leptin stimulates triglyceride depletion in white adipose tissue without increasing free fatty acid release, thus favouring fatty acids versus glucose as a fuel source. Glucose 156-163 leptin Homo sapiens 13-19 11375799-9 2001 Orexin-A and leptin concentrations showed a significant inverse correlation with serum glucose, insulin, C-peptide, and beta-hydroxybutyrate concentrations. Glucose 87-94 leptin Homo sapiens 13-19 11439293-9 2001 When a multiple linear regression model was used without body mass index (BMI), the correlation between leptin and IMT was maintained in both men (P<0.01) and women (P<0.005), independent of age, insulin sensitivity, smoking habits, systolic blood pressure, fasting glucose, triglycerides, cholesterol, LDL-cholesterol and HDL-cholesterol. Glucose 272-279 leptin Homo sapiens 104-110 11380499-10 2001 RESULTS: Serum leptin on day 1 (baseline) was significantly associated with serum insulin (r = 0.30, P < 0.05) and insulin:glucose ratio (r = 0.29, P < 0.05) in infants < 34 weeks gestation. Glucose 126-133 leptin Homo sapiens 15-21 11380499-12 2001 In addition, the duration between the last dose of antenatal dexamethasone and delivery significantly influenced the serum concentrations of leptin (r = - 0.27, P < 0.05), cortisol (r = 0.52, P < 0.001), plasma ACTH (r = 0.28, P < 0.05) and insulin:glucose ratio (r = - 0.27, P < 0.05) on the first day of life. Glucose 258-265 leptin Homo sapiens 141-147 11380499-16 2001 Serum leptin was significantly associated with serum insulin and insulin:glucose ratio supporting the hypothesis that an "adipoinsular axis" exists and is likely to be functional before 34 weeks of gestation. Glucose 73-80 leptin Homo sapiens 6-12 11319659-6 2001 Leptin decrease after 3 months of GH administration was correlated inversely with the increase in first phase insulin response to intravenous glucose tolerance test (IVGTT) (r2=-0.595, P<0.001). Glucose 142-149 leptin Homo sapiens 0-6 11145919-2 2001 It has been demonstrated by in vivo and in vitro studies, that leptin increases glucose and fatty acid metabolism in skeletal muscle. Glucose 80-87 leptin Homo sapiens 63-69 11274900-5 2001 Only in male patients, leptin levels were inversely correlated with HDL-cholesterol, fasting plasma glucose (FPG), and HbA(1C). Glucose 100-107 leptin Homo sapiens 23-29 11270672-4 2001 RESULTS: Plasma leptin (ng/ml) was higher (p < 0.001) in women with gestational diabetes (24.9 +/- 1.6) than in women with normal glucose tolerance (18.2 +/- 1.5) and increased in both groups when compared with the non-pregnant women (8.2 +/- 1.3; p < 0.0005). Glucose 133-140 leptin Homo sapiens 16-22 11270672-8 2001 Leptin correlated in women with gestational diabetes with basal plasma concentrations of glucose (p < 0.02), insulin (p < 0.004) and proinsulin (p < 0.01) as well as with BMI (p < 0.001) and overall pregnancy induced maternal weight gain (p < 0.009). Glucose 89-96 leptin Homo sapiens 0-6 11270672-10 2001 CONCLUSION/INTERPRETATION: Our data show that women with gestational diabetes without any change in plasma leptin upon oral glucose loading have increased plasma leptin concentrations during and after pregnancy, a clear association of plasma leptin with the respective concentration of glucose and insulin resistance as well as with changes in body weight, and a failure to normalize spontaneously BMI to the same extent as pregnant women with normal glucose tolerance when compared with matched control subjects. Glucose 286-293 leptin Homo sapiens 162-168 11270672-10 2001 CONCLUSION/INTERPRETATION: Our data show that women with gestational diabetes without any change in plasma leptin upon oral glucose loading have increased plasma leptin concentrations during and after pregnancy, a clear association of plasma leptin with the respective concentration of glucose and insulin resistance as well as with changes in body weight, and a failure to normalize spontaneously BMI to the same extent as pregnant women with normal glucose tolerance when compared with matched control subjects. Glucose 286-293 leptin Homo sapiens 162-168 11270672-10 2001 CONCLUSION/INTERPRETATION: Our data show that women with gestational diabetes without any change in plasma leptin upon oral glucose loading have increased plasma leptin concentrations during and after pregnancy, a clear association of plasma leptin with the respective concentration of glucose and insulin resistance as well as with changes in body weight, and a failure to normalize spontaneously BMI to the same extent as pregnant women with normal glucose tolerance when compared with matched control subjects. Glucose 286-293 leptin Homo sapiens 162-168 11270672-10 2001 CONCLUSION/INTERPRETATION: Our data show that women with gestational diabetes without any change in plasma leptin upon oral glucose loading have increased plasma leptin concentrations during and after pregnancy, a clear association of plasma leptin with the respective concentration of glucose and insulin resistance as well as with changes in body weight, and a failure to normalize spontaneously BMI to the same extent as pregnant women with normal glucose tolerance when compared with matched control subjects. Glucose 286-293 leptin Homo sapiens 162-168 11027500-3 2000 In fact, leptin secretion was virtually eliminated in the presence of glucose uptake inhibitors. Glucose 70-77 leptin Homo sapiens 9-15 11150869-5 2001 A positive correlation was also found between maternal leptin concentrations and fasting serum insulin levels, as well as between leptin concentrations and plasma glucose levels obtained 1 h after the administration of 50 g of glucose in women with gestational diabetes (r = 0.84, p < 0.001, and r = 0.92, p < 0.001, respectively). Glucose 163-170 leptin Homo sapiens 130-136 11150869-5 2001 A positive correlation was also found between maternal leptin concentrations and fasting serum insulin levels, as well as between leptin concentrations and plasma glucose levels obtained 1 h after the administration of 50 g of glucose in women with gestational diabetes (r = 0.84, p < 0.001, and r = 0.92, p < 0.001, respectively). Glucose 227-234 leptin Homo sapiens 130-136 11244470-2 2001 OBJECTIVE: To assess the acute regulation of leptin concentrations by insulin, glucose and free fatty acids (FFAs). Glucose 79-86 leptin Homo sapiens 45-51 11040167-4 2000 Serum leptin correlated significantly with serum insulin, insulin:glucose ratio, birth weight, body length, body mass index, placenta weight, and maternal HbA(1c). Glucose 66-73 leptin Homo sapiens 6-12 11040167-8 2000 The significant association between serum leptin and insulin or insulin:glucose ratio supports the hypothesis that a functional adipoinsular axis might exist in term newborns. Glucose 72-79 leptin Homo sapiens 42-48 11040168-6 2000 Serum leptin on day 1 was significantly associated with serum insulin, insulin:glucose ratio, and plasma ACTH in infants less than 34 weeks gestation; serum leptin on day 1 and day 4-5 were significantly correlated with insulin:glucose ratio in infants 34 or more weeks gestation. Glucose 79-86 leptin Homo sapiens 6-12 11040168-6 2000 Serum leptin on day 1 was significantly associated with serum insulin, insulin:glucose ratio, and plasma ACTH in infants less than 34 weeks gestation; serum leptin on day 1 and day 4-5 were significantly correlated with insulin:glucose ratio in infants 34 or more weeks gestation. Glucose 228-235 leptin Homo sapiens 157-163 11150869-0 2001 Maternal plasma leptin levels and their relationship to insulin and glucose in gestational-onset diabetes. Glucose 68-75 leptin Homo sapiens 16-22 11061500-7 2000 Inhibition of UDP-N-acetylglucosamine biosynthesis with 6-diazo-5-oxo-norleucine reduced glucose-stimulated leptin release from cultured adipocytes 21.8+/-32.4% (P = 0.0395; n = 12) and ob gene expression 19.9+/-18.9% (P = 0.0208; n = 8) by 48 h of treatment. Glucose 89-96 leptin Homo sapiens 108-114 10988175-8 2000 Serum leptin levels correlated positively with BMI, skinfold thickness, serum cholesterol, low-density lipoprotein cholesterol, insulin, insulin/glucose ratio, apnea-hypopnea index, and oxygen desaturation time; multiple stepwise regression analysis identified skinfold thickness, waist/hip ratio, serum low-density lipoprotein cholesterol, and diastolic BP as independent correlates, while only serum insulin and diastolic BP were independent correlates in OSA subjects. Glucose 145-152 leptin Homo sapiens 6-12 10997652-9 2000 Based on in vitro studies, the effect of insulin to stimulate leptin production appears to involve increased glucose metabolism. Glucose 109-116 leptin Homo sapiens 62-68 10919937-12 2000 Last, the change in leptin was predicted accurately by changes in glucose, triacylglycerol, and fatty acids (r(2) = 0.87, P < 10(-5)). Glucose 66-73 leptin Homo sapiens 20-26 10946865-11 2000 If adipocytes from females are more responsive to relevant in vivo stimuli for leptin secretion such as insulin or glucose, this could contribute to the gender difference in serum leptin. Glucose 115-122 leptin Homo sapiens 79-85 10946865-11 2000 If adipocytes from females are more responsive to relevant in vivo stimuli for leptin secretion such as insulin or glucose, this could contribute to the gender difference in serum leptin. Glucose 115-122 leptin Homo sapiens 180-186 10954026-9 2000 When adjusted for the BMI and gender, a statistically significant gender-related difference in mean plasma leptin was observed across the 3 glucose tolerance subgroups (P < .03 by analysis of covariance [ANCOVA]). Glucose 140-147 leptin Homo sapiens 107-113 10954026-12 2000 In univariate analysis in the same female subgroup, plasma leptin correlated positively with fasting insulin (rs = +.43, P < .06) and negatively with 2-hour post-75-g glucose load plasma glucose concentration (rs = -.54, P < .02). Glucose 170-177 leptin Homo sapiens 59-65 10954026-12 2000 In univariate analysis in the same female subgroup, plasma leptin correlated positively with fasting insulin (rs = +.43, P < .06) and negatively with 2-hour post-75-g glucose load plasma glucose concentration (rs = -.54, P < .02). Glucose 190-197 leptin Homo sapiens 59-65 10954026-13 2000 In a multiple regression model controlling for the BMI in the female subgroup, circulating insulin and glucose concentrations 2 hours after the 75-g glucose load were good predictors of fasting plasma leptin (r = +.38, P = .02 and r = -.70, P < .001, respectively). Glucose 103-110 leptin Homo sapiens 201-207 10954026-13 2000 In a multiple regression model controlling for the BMI in the female subgroup, circulating insulin and glucose concentrations 2 hours after the 75-g glucose load were good predictors of fasting plasma leptin (r = +.38, P = .02 and r = -.70, P < .001, respectively). Glucose 149-156 leptin Homo sapiens 201-207 10954026-14 2000 Leptin levels in women appear to be influenced independently and to an important degree by ambient plasma glucose and plasma insulin concentrations. Glucose 106-113 leptin Homo sapiens 0-6 10954026-15 2000 These findings suggest that the synthesis of leptin by adipose tissue is more susceptible to in vivo regulation by insulin and glucose in women than in men. Glucose 127-134 leptin Homo sapiens 45-51 11074239-8 2000 Leptin was correlated positively with body mass index and CPE (p<0.001) and inversely with glucose (p = 0.001) and HbA1c (p<0.05) in the combined group. Glucose 94-101 leptin Homo sapiens 0-6 10997652-10 2000 Blockade of glucose transport or glycolysis inhibits leptin expression and secretion in isolated adipocytes. Glucose 12-19 leptin Homo sapiens 53-59 10997652-12 2000 Alterations in insulin-mediated glucose metabolism in adipose tissue are likely to mediate the effects of energy restriction to decrease, and refeeding to increase, circulating leptin levels. Glucose 32-39 leptin Homo sapiens 177-183 10997652-13 2000 Changes in glucose metabolism may also explain the observation that high-fat meals lower 24h circulating leptin levels relative to high-carbohydrate meals in human subjects, suggesting a mechanism that may contribute to the effects that high-fat diets have in promoting increased energy intake, weight gain and obesity. Glucose 11-18 leptin Homo sapiens 105-111 10837280-8 2000 Within both groups, leptin decreased significantly from baseline to 2 h after an oral-glucose-tolerance test. Glucose 86-93 leptin Homo sapiens 20-26 10856891-7 2000 Using this assay we investigated the short-term effects of insulin, adrenaline and glucagon (all modulators of blood glucose) on plasma leptin levels. Glucose 117-124 leptin Homo sapiens 136-142 10992810-0 2000 Effect of peritoneal glucose load on plasma leptin concentration in continuous ambulatory peritoneal dialysis patients. Glucose 21-28 leptin Homo sapiens 44-50 10992810-1 2000 This study was performed to investigate the effect of peritoneal glucose load on plasma leptin concentrations in the continuous ambulatory peritoneal dialysis (CAPD) performed on 13 non-diabetic ESRD patients. Glucose 65-72 leptin Homo sapiens 88-94 10992810-9 2000 Changes of leptin concentration were significantly correlated with the changes of peritoneal glucose absorption at PD1. Glucose 93-100 leptin Homo sapiens 11-17 10992810-10 2000 In conclusion, continuous peritoneal glucose load may affect plasma leptin concentrations in CAPD patients. Glucose 37-44 leptin Homo sapiens 68-74 10711659-2 2000 We studied leptin concentrations in human milk and its relationships with maternal and infant plasma leptin concentrations, adiposity, serum glucose, insulin, lipid and lipoprotein levels. Glucose 141-148 leptin Homo sapiens 11-17 10833328-9 2000 Changes in leptin mRNA were directly related to glucose disposal rates during physiologic hyperinsulinemia (r = 0.54, P < 0.04). Glucose 48-55 leptin Homo sapiens 11-17 10720074-1 2000 Circulating plasma insulin and glucose levels are thought to be major regulators of leptin secretion. Glucose 31-38 leptin Homo sapiens 84-90 10720074-3 2000 Here, we tested the hypothesis that in humans also leptin secretion is primarily regulated by glucose uptake and only secondarily by plasma insulin and glucose. Glucose 94-101 leptin Homo sapiens 51-57 10720074-3 2000 Here, we tested the hypothesis that in humans also leptin secretion is primarily regulated by glucose uptake and only secondarily by plasma insulin and glucose. Glucose 152-159 leptin Homo sapiens 51-57 10720074-9 2000 However, when the total amount of dextrose infused during the clamp (grams of dextrose per kg BW) was included into the regression model, this variable was significantly related to the changes in serum leptin (P = 0.001), whereas circulating insulin and glucose had no additional effect. Glucose 34-42 leptin Homo sapiens 202-208 10720074-9 2000 However, when the total amount of dextrose infused during the clamp (grams of dextrose per kg BW) was included into the regression model, this variable was significantly related to the changes in serum leptin (P = 0.001), whereas circulating insulin and glucose had no additional effect. Glucose 78-86 leptin Homo sapiens 202-208 10551339-11 1999 Control serum leptin was positively correlated (p < 0.05) to BF (r = 0.88) and glucose (r=0.96), and negatively correlated to REE (r= -0.81). Glucose 82-89 leptin Homo sapiens 14-20 10989952-5 2000 It generates insulin-like signals for glucose transport and glycogen synthesis via leptin receptors and the PI3-kinase and could, therefore, play a role as a mediator of obesity-related insulin resistance. Glucose 38-45 leptin Homo sapiens 83-89 11798713-0 1999 [Dynamic effect of the blood glucose and insulin on serum leptin concentration during oral glucose tolerance test]. Glucose 29-36 leptin Homo sapiens 58-64 11798713-0 1999 [Dynamic effect of the blood glucose and insulin on serum leptin concentration during oral glucose tolerance test]. Glucose 91-98 leptin Homo sapiens 58-64 11798713-1 1999 OBJECTIVE: To investigate the effects of internal change of plasma glucose and serum insulin levels on serum leptin concentrations during oral glucose tolerance test (OGTT) in normal subjects and type II diabetics (DM). Glucose 67-74 leptin Homo sapiens 109-115 11798713-1 1999 OBJECTIVE: To investigate the effects of internal change of plasma glucose and serum insulin levels on serum leptin concentrations during oral glucose tolerance test (OGTT) in normal subjects and type II diabetics (DM). Glucose 143-150 leptin Homo sapiens 109-115 10557022-7 1999 Leptin concentration also correlated with fasting insulin (r=0.41) and with glucose and insulin concentrations 2 h after a glucose load (r=0.19 and 0.49). Glucose 76-83 leptin Homo sapiens 0-6 10557022-7 1999 Leptin concentration also correlated with fasting insulin (r=0.41) and with glucose and insulin concentrations 2 h after a glucose load (r=0.19 and 0.49). Glucose 123-130 leptin Homo sapiens 0-6 10689640-3 2000 In cord blood, leptin was significantly higher than in 3 day-old infants (p < 0.05), and correlated only with maternal insulin and glucose (r = 0.5, p < 0.01 and r = 0.4, p < 0.05, respectively). Glucose 134-141 leptin Homo sapiens 15-21 11225217-8 1999 RESULTS: Leptin correlated with log fat % and BMI, body weight and waist circumference in different categories of glucose tolerance (Pearson"s correlation test). Glucose 114-121 leptin Homo sapiens 9-15 11225217-12 1999 Gender showed a significant effect on leptin concentration (F = 11.0, df = 1.39, P = 0.002) after adjusting for the effect of covariates i.e. percentage of fat (log), BMI, age, WHR and 2 h plasma glucose by ANCOVA. Glucose 196-203 leptin Homo sapiens 38-44 10489106-8 1999 However, fasting plasma leptin concentrations were related to steady-state plasma glucose (SSPG) concentrations, a measure of insulin sensitivity by insulin suppression test, in men only (P < 0.001). Glucose 82-89 leptin Homo sapiens 24-30 10479193-7 1999 The change in leptin per kilogram fat mass correlated with that in glucose concentrations [r = 0.538 (P = 0.012) at week 1 and r = 0.447 (P = 0.042) at week 4] but not with that in fat mass. Glucose 67-74 leptin Homo sapiens 14-20 10404835-0 1999 Intrinsic site-specific differences in the expression of leptin in human adipocytes and its autocrine effects on glucose uptake. Glucose 113-120 leptin Homo sapiens 57-63 10477210-3 1999 The aim of this study was to relate serum leptin levels during pregnancy to glucose tolerance, body mass index (BMI) and specific metabolic variables, such as specific insulin and proinsulin. Glucose 76-83 leptin Homo sapiens 42-48 10477210-8 1999 In women with mild gestational diabetes (GDM, n = 55), leptin levels were lower compared to women with normal glucose tolerance (n = 166) after adjusting for BMI and fasting insulin (26.9 vs. 19.4 ng/ml, P = 0.0001). Glucose 110-117 leptin Homo sapiens 55-61 10444423-5 1999 Reductions in leptin levels were directly associated with reductions in serum triglycerides and cholesterol, a finding that was independent of improvements in glucose control. Glucose 159-166 leptin Homo sapiens 14-20 10494872-3 1999 In this study, we examined whether leptin levels in cord blood of infants of type 1 diabetic mothers (n = 29), gestational diabetic mothers (n = 6 and controls (n = 96) correlated with level of maternal glucose control, maternal leptin level at delivery, gender, fetal and placental size, and C-peptide in cord blood at birth. Glucose 203-210 leptin Homo sapiens 35-41 10404835-2 1999 In human mature adipocytes isolated from omental (OM) and s.c. tissue, we found that leptin (10 and 100 ng/mL) significantly reduced insulin-mediated glucose uptake by 40% (P<0.05). Glucose 150-157 leptin Homo sapiens 85-91 10404835-10 1999 The autocrine effects of leptin to inhibit insulin-stimulated glucose uptake and subsequent lipogenesis in adipose tissue may, therefore, be less in OM adipocytes and may play a role in determining visceral obesity. Glucose 62-69 leptin Homo sapiens 25-31 10354196-12 1999 Plasma leptin correlated with plasma insulin concentration only in hyperthyroid patients (P < 0.01, r = 0.64), who presented with blunted stimulation of insulin release and higher plasma glucose (P < 0.05) than hypothyroid subjects. Glucose 190-197 leptin Homo sapiens 7-13 10411236-0 1999 Leptin concentrations during oral glucose tolerance test (OGTT) in obese and normal weight women. Glucose 34-41 leptin Homo sapiens 0-6 10411236-1 1999 OBJECTIVE: To examine possible changes of leptin concentrations after the acute administration of glucose orally (OGTT). Glucose 98-105 leptin Homo sapiens 42-48 10411236-8 1999 In obese women, leptin increased significantly in comparison to its basal concentrations 30 and 60 min after the glucose loading. Glucose 113-120 leptin Homo sapiens 16-22 10411236-15 1999 CONCLUSION: A significant increase in leptin concentrations was found 30 and 60 min after glucose loading in obese individuals. Glucose 90-97 leptin Homo sapiens 38-44 10411242-7 1999 In fasted mice, human leptin (n = 24) increased plasma glucose by 1.5+/-0.2 mmol/l (P = 0.041), plasma insulin by 95+/-22 pmol/l (P = 0.018), and plasma glucagon by 16+/-3 pg/ml (P = 0.025), relative to saline-injected control animals. Glucose 55-62 leptin Homo sapiens 22-28 10999153-1 1999 OBJECTIVE: To study the relationship between serum leptin and circulating insulin under basal and in response to oral glucose administration in hyperinsulinemic patients with or without obesity. Glucose 118-125 leptin Homo sapiens 51-57 10354196-13 1999 CONCLUSION: The results indicate that (a) the correlation of leptin with body fat mass is preserved in thyroid dysfunction, (b) plasma leptin is markedly increased in obese hypothyroid hyperinsulinaemic patients and (c) plasma leptin is not affected by oral glucose loading. Glucose 258-265 leptin Homo sapiens 135-141 10354196-13 1999 CONCLUSION: The results indicate that (a) the correlation of leptin with body fat mass is preserved in thyroid dysfunction, (b) plasma leptin is markedly increased in obese hypothyroid hyperinsulinaemic patients and (c) plasma leptin is not affected by oral glucose loading. Glucose 258-265 leptin Homo sapiens 135-141 10080951-6 1999 These results suggest that physiological human leptin concentration is able to importantly affect glucose (but not arginine) stimulated insulin release from human islets only after prolonged exposure. Glucose 98-105 leptin Homo sapiens 47-53 10353113-6 1999 RESULTS: Area under the curve for glucose (AUCglu) and insulin (AUCins) levels after OGTT correlated with serum leptin level in men (r = 0.58, p = 0.005 and r = 0.72, p < 0.0001, respectively). Glucose 34-41 leptin Homo sapiens 112-118 10353113-11 1999 CONCLUSIONS: Insulin-sensitivity in men, and insulin-secretion (calculated after intravenous glucose) in women independently predict serum leptin level. Glucose 93-100 leptin Homo sapiens 139-145 10353113-12 1999 Furthermore, insulin response after oral glucose is independently associated with serum leptin level only in men. Glucose 41-48 leptin Homo sapiens 88-94 10078849-11 1999 The variations of average 24h FFA and average 24h glucose concentrations almost fully explained the variation in average 24h leptin concentration across trials. Glucose 50-57 leptin Homo sapiens 125-131 10102253-6 1999 After adjustment for BMI and GDR, leptin levels remained significantly correlated with fasting insulin, fasting glucose, triglyceride, apolipoprotein B, and systolic blood pressure. Glucose 112-119 leptin Homo sapiens 34-40 10102253-7 1999 Leptin levels were also correlated with the number of metabolic risk factors (dyslipidemia, systolic blood pressure, and fasting glucose). Glucose 129-136 leptin Homo sapiens 0-6 10069665-4 1999 DESIGN AND METHODS: Multiple regression analysis was employed to analyse the relationship between fasting serum leptin levels and levels of fasting serum insulin, insulin sensitivity index and acute insulin response (AIR) in a population-based study of 380 young healthy Caucasians who underwent a combined intravenous glucose and tolbutamide tolerance test. Glucose 319-326 leptin Homo sapiens 112-118 10022436-4 1999 Leptin (6.25 nM) suppressed insulin secretion of normal islets by 20% at 5.6 mM glucose. Glucose 80-87 leptin Homo sapiens 0-6 10022436-5 1999 Intracellular calcium responses to 16.7 mM glucose were rapidly reduced by leptin. Glucose 43-50 leptin Homo sapiens 75-81 10022436-7 1999 Leptin also reduced proinsulin messenger ribonucleic acid levels that were increased in islets by treatment with 10 nM glucagon-like peptide-1 in the presence of either 5.6 or 11.1 mM glucose. Glucose 184-191 leptin Homo sapiens 0-6 10102253-5 1999 RESULTS: Leptin levels were significantly correlated with body mass index (BMI) (r = 0.494), fasting insulin (r = 0.576), whole-body glucose disposal rate (GDR) (r = -0.566), fasting glucose (r = 0.510) total triglycerides (r = 0.294), apolipoprotein B (r = 0.223), systolic blood pressure (r = 0.223), and LDL size (r = -0.244). Glucose 133-140 leptin Homo sapiens 9-15 10102253-5 1999 RESULTS: Leptin levels were significantly correlated with body mass index (BMI) (r = 0.494), fasting insulin (r = 0.576), whole-body glucose disposal rate (GDR) (r = -0.566), fasting glucose (r = 0.510) total triglycerides (r = 0.294), apolipoprotein B (r = 0.223), systolic blood pressure (r = 0.223), and LDL size (r = -0.244). Glucose 183-190 leptin Homo sapiens 9-15 10334310-5 1999 We have reported that adipocyte glucose utilization is involved in insulin-induced leptin secretion in vitro. Glucose 32-39 leptin Homo sapiens 83-89 9814618-10 1998 Furthermore, the insulin response to an oral glucose load was significantly related to both plasma angiotensinogen (r=0.22, P< 0.05) and plasma leptin (r=0.47, P< 0.001). Glucose 45-52 leptin Homo sapiens 147-153 9550541-2 1998 The aim of this study was to examine the relationship between decrements of serum leptin concentrations and changes of hormonal (insulin and cortisol) and metabolic (glucose, ketones, and fatty acids) parameters involved in the metabolic adaptation to energy restriction in normal-weight humans. Glucose 166-173 leptin Homo sapiens 82-88 9626115-8 1998 The diurnal and the sleep-related variations of plasma leptin mirrored those of body temperature and roughly paralleled those of plasma glucose and insulin; the amplitudes of the diurnal leptin variations were significantly correlated with the amplitudes of the diurnal body temperature variations (P < 0.05). Glucose 136-143 leptin Homo sapiens 55-61 9626115-8 1998 The diurnal and the sleep-related variations of plasma leptin mirrored those of body temperature and roughly paralleled those of plasma glucose and insulin; the amplitudes of the diurnal leptin variations were significantly correlated with the amplitudes of the diurnal body temperature variations (P < 0.05). Glucose 136-143 leptin Homo sapiens 187-193 9626115-9 1998 Plasma leptin levels also displayed irregular pulses of low amplitude (mean duration, 70 min) that were not affected by sleep, but were associated with a significant decrease in glucose and insulin levels (P < 0.01). Glucose 178-185 leptin Homo sapiens 7-13 9550541-8 1998 In contrast, leptin was higher in women before (16.2 +/- 1.9 ng/mL) and after (6.0 +/- 0.8 ng/mL) restriction and decreased more than in men (%delta, -61% +/- 4%, P < .02 v men), whereas the decrease of insulin in women was less than in men: 10.1 +/- 1.9 to 6.1 +/- 1.0 microU/mL (%delta, -31% +/- 9%, P < .0025; P < .0005 v men), perhaps because glucose decreased less in women than in men. Glucose 356-363 leptin Homo sapiens 13-19 9550541-9 1998 Overall, the changes of leptin during fasting were independently correlated with the changes of glucose (r = .53, P < .007), NEFA (r = .53, P < .01), and BOHB (r = .65, P < .001). Glucose 96-103 leptin Homo sapiens 24-30 9550541-10 1998 In addition, the change of leptin correlated with a combined index of the parameters that reflect decreased glucose availability and increased lipolysis ([deltaglucose + deltainsulin + deltaNEFA]/3, r = .73, P < .0001) or a combined index of parameters that would be expected to limit glucose uptake by adipocytes ([deltaglucose + deltainsulin + deltacortisol]/3, r = .48, P < .02). Glucose 160-167 leptin Homo sapiens 27-33 9550541-10 1998 In addition, the change of leptin correlated with a combined index of the parameters that reflect decreased glucose availability and increased lipolysis ([deltaglucose + deltainsulin + deltaNEFA]/3, r = .73, P < .0001) or a combined index of parameters that would be expected to limit glucose uptake by adipocytes ([deltaglucose + deltainsulin + deltacortisol]/3, r = .48, P < .02). Glucose 108-115 leptin Homo sapiens 27-33 9550541-12 1998 Furthermore, decreases of circulating leptin during negative energy balance are related to changes of endocrine and metabolic parameters, suggesting that leptin secretion may be regulated by alterations of adipocyte glucose and lipid metabolism, ie, decreased glucose uptake and metabolism and increased lipolysis. Glucose 216-223 leptin Homo sapiens 38-44 9550541-12 1998 Furthermore, decreases of circulating leptin during negative energy balance are related to changes of endocrine and metabolic parameters, suggesting that leptin secretion may be regulated by alterations of adipocyte glucose and lipid metabolism, ie, decreased glucose uptake and metabolism and increased lipolysis. Glucose 216-223 leptin Homo sapiens 154-160 9550541-12 1998 Furthermore, decreases of circulating leptin during negative energy balance are related to changes of endocrine and metabolic parameters, suggesting that leptin secretion may be regulated by alterations of adipocyte glucose and lipid metabolism, ie, decreased glucose uptake and metabolism and increased lipolysis. Glucose 260-267 leptin Homo sapiens 38-44 9550541-12 1998 Furthermore, decreases of circulating leptin during negative energy balance are related to changes of endocrine and metabolic parameters, suggesting that leptin secretion may be regulated by alterations of adipocyte glucose and lipid metabolism, ie, decreased glucose uptake and metabolism and increased lipolysis. Glucose 260-267 leptin Homo sapiens 154-160 9152742-7 1997 RESULTS: Leptin levels were significantly correlated with fasting insulin (r = 0.58), insulin area (r = 0.45), overall (r = -0.57), non-oxidative (r = -0.51) and oxidative (r = -0.51) whole body glucose disposal (all P-values < 0.001). Glucose 195-202 leptin Homo sapiens 9-15 9451467-4 1997 Here, we demonstrate that leptin acts as an inhibitor of glucose-induced (20 mM) insulin secretion from isolated human islets. Glucose 57-64 leptin Homo sapiens 26-32 9389430-1 1997 We have recently shown that leptin mimicks insulin effects on glucose transport and glycogen synthesis through a phosphatidylinositol-3 (PI) kinase dependent pathway in C2C12 myotubes. Glucose 62-69 leptin Homo sapiens 28-34 9226485-6 1997 Leptin concentrations were negatively correlated with fasting glucose in all groups combined (p = -0.24, P = 0.0001) and particularly in NIDDM subjects (p = 0.31, P = 0.0054). Glucose 62-69 leptin Homo sapiens 0-6 9226485-9 1997 Multivariate analysis revealed that fasting glucose was independently associated with serum leptin concentrations (F = 12.5, P = 0.0005). Glucose 44-51 leptin Homo sapiens 92-98 9249764-14 1997 Consequently, extremely elevated serum leptin may play a role in reducing glucose-stimulated insulin secretion and glucose intolerance in CRF. Glucose 74-81 leptin Homo sapiens 39-45 9249764-14 1997 Consequently, extremely elevated serum leptin may play a role in reducing glucose-stimulated insulin secretion and glucose intolerance in CRF. Glucose 115-122 leptin Homo sapiens 39-45 9177365-9 1997 Leptin concentrations for PCOS, but not NC, correlated positively with 24-h mean glucose levels and inversely with 24-h mean LH levels and 24-h mean LH pulse amplitude. Glucose 81-88 leptin Homo sapiens 0-6 9345321-3 1997 By regression analysis adjusted by age, BMI, and V + S, serum leptin levels were still highly and positively correlated with plasma insulin levels during 75 g oral glucose load (p < 0.001), insulin resistance index(p < 0.001), and beta cell function index(p = 0.009) in homeostasis model assessment. Glucose 164-171 leptin Homo sapiens 62-68 9152742-8 1997 After adjustment for body mass index, leptin levels remained significantly correlated with fasting insulin (r = 0.44), insulin area (r = 0.40), overall (r = -0.40), non-oxidative (r = -0.28) and oxidative (r = -0.33) whole body glucose disposal although the magnitude of the associations was considerably decreased. Glucose 228-235 leptin Homo sapiens 38-44 8866554-5 1996 When responses of leptin to fasting and refeeding were compared with that of glucose, insulin, fatty acids, and ketones, a reverse relationship between leptin and beta-OH-butyrate was found. Glucose 77-84 leptin Homo sapiens 152-158 10374312-12 1997 There was significant negative correlation between OP levels and body mass index, serum concentration of glucose, cholesterol and triglycerides. Glucose 105-112 leptin Homo sapiens 51-53 9135699-2 1997 DESIGN AND PATIENTS: Correlation of fasting serum leptin concentrations with anthropometric measures and multiple metabolic parameters including insulin and glucose responses to a 2-hour 75-g oral glucose tolerance test (OGTT) in 85 women with PCOS (17-36 years, body mass index (BMI) 29.9 +/- 0.9 kg/m2, mean +/- SD) and 18 control women (25-47 years, BMI 25 +/- 1.7 kg/m2). Glucose 157-164 leptin Homo sapiens 50-56 9013847-7 1997 Leptin may be, essentially, a counter-regulatory hormone limiting the insulin drive to store energy in the form of fat, its effects reaching from a decrease in food intake to lower insulin secretion and increased resistance to insulin and lower glucose uptake and fat synthesis by WAT. Glucose 245-252 leptin Homo sapiens 0-6 9013743-9 1996 The regional difference in leptin expression was similar in the patients with impaired glucose tolerance/type-2 diabetes and those with normal glucose tolerance. Glucose 87-94 leptin Homo sapiens 27-33 8866564-12 1996 In conclusion, plasma leptin 1) reflects body fat content and 2) correlates to insulin secretion independently of percent body fat in postmenopausal women with normal glucose tolerance. Glucose 167-174 leptin Homo sapiens 22-28 8866554-7 1996 Small amounts of infused glucose equal to the estimated contribution of gluconeogenesis, which was sufficient to prevent rise in ketogenesis, also prevented a fall in leptin. Glucose 25-32 leptin Homo sapiens 167-173 8784108-5 1996 Serum leptin correlated positively with serum insulin (r = 0.51, p < 0.001) and with plasma glucose (r = 0.61, p < 0.001). Glucose 95-102 leptin Homo sapiens 6-12 8784108-9 1996 The lack of leptin changes during fasting, when basal insulin and glucose levels were maintained at basal levels, suggested that insulin and/or glucose may play a role in the regulation of leptin release. Glucose 144-151 leptin Homo sapiens 189-195 34669746-10 2021 After adjustment for serum insulin and leptin, the correlation between serum cortisol and fasting glucose remained significant. Glucose 98-105 leptin Homo sapiens 39-45 8621378-2 1996 It has been demonstrated that exogenous human OB protein (leptin) treatment reduces food intake and weight gain, as well as insulin, glucose, and corticosterone levels in ob/ob mice. Glucose 133-140 leptin Homo sapiens 58-64 34480980-4 2021 Leptin also enhanced DCs glycolysis with increased glucose consumption, lactate production, and the expression of hexokinase 2 (HK2). Glucose 51-58 leptin Homo sapiens 0-6 34480980-5 2021 In addition, the activation of DCs stimulated by leptin could be inhibited by the glycolysis inhibitor 2-deoxy-D-glucose (2-DG). Glucose 113-120 leptin Homo sapiens 49-55 34183284-0 2021 The association between body composition, leptin levels and glucose dysregulation in youth with cystic fibrosis. Glucose 60-67 leptin Homo sapiens 42-48 34183284-3 2021 Differences in body composition and leptin levels between the categories of glucose tolerance were assessed in youth with CF and healthy controls. Glucose 76-83 leptin Homo sapiens 36-42 34384107-10 2021 Importantly, co-treatment of AMH plus leptin upregulates the expression of pro-apoptotic proteins, such as Bax, caspase-3, and caspase-8 after incubating with a high level of glucose. Glucose 175-182 leptin Homo sapiens 38-44 34604014-15 2021 CONCLUSIONS: (1) Increased leptin concentration observed in women diagnosed de novo with PCOS as well as positive correlations between leptin and HOMA-IR, and IRI/glucose and BMI may indicate a potential role of leptin in the reduction of tissue sensitivity to insulin. Glucose 163-170 leptin Homo sapiens 212-218 34604014-11 2021 In patients with PCOS, a positive correlation was found between the concentrations of insulin and leptin and concentrations of leptin and IRI/glucose. Glucose 142-149 leptin Homo sapiens 98-104 34604014-11 2021 In patients with PCOS, a positive correlation was found between the concentrations of insulin and leptin and concentrations of leptin and IRI/glucose. Glucose 142-149 leptin Homo sapiens 127-133 34604014-13 2021 In the PCOS group, a positive correlation was found between BMI and leptin concentration (r = 0.7176; p < 0.0001) and carbohydrate metabolism, such as insulin (r = 0.5524; p = 0.0003), glucose (r = 0.3843; p = 0.0157), HOMA-IR (r = 0.5895; p < 0.0001), and IRI/glucose (r = 0.3872; p = 0.0163). Glucose 185-192 leptin Homo sapiens 68-74 34604014-13 2021 In the PCOS group, a positive correlation was found between BMI and leptin concentration (r = 0.7176; p < 0.0001) and carbohydrate metabolism, such as insulin (r = 0.5524; p = 0.0003), glucose (r = 0.3843; p = 0.0157), HOMA-IR (r = 0.5895; p < 0.0001), and IRI/glucose (r = 0.3872; p = 0.0163). Glucose 261-268 leptin Homo sapiens 68-74 35255598-3 2022 To achieve normoglycemia, specific populations of neurons and glia in the hypothalamus sense changes in the blood concentrations of glucose and of glucoregulatory hormones such as insulin, leptin, glucagon-like peptide 1, and glucagon. Glucose 132-139 leptin Homo sapiens 189-195 34341568-4 2021 Selective deletion of LepR in tanycytes blocks leptin entry into the brain, inducing not only increased food intake and lipogenesis but also glucose intolerance through attenuated insulin secretion by pancreatic beta-cells, possibly via altered sympathetic nervous tone. Glucose 141-148 leptin Homo sapiens 47-53 35020844-2 2022 In the present exploratory study, IgG leptin-reactive antibodies were analyzed for the first time in children and adolescents according to body mass index (BMI) and were correlated with biochemical profile (lipid profile, insulin, glucose and leptin) and metabolic risk indexes (HOMA-IR, HOMA-beta, AIP). Glucose 231-238 leptin Homo sapiens 38-44 35383744-5 2022 Fasting serum leptin and glucose were measured by ELISA and glucose oxidase method respectively. Glucose 60-67 leptin Homo sapiens 14-20 35334523-0 2022 -2548G>A LEP Polymorphism Is Positively Associated with Increased Leptin and Glucose Levels in Obese Saudi Patients Irrespective of Blood Pressure Status. Glucose 77-84 leptin Homo sapiens 9-12 35334523-1 2022 Background and Objectives: In this study, we aimed to investigate the link between common -2548G>A (rs7799039) promoter variant of the human leptin gene (LEP) with leptin and serum glucose leptin levels in obese Saudi patients. Glucose 181-188 leptin Homo sapiens 141-147 35334523-1 2022 Background and Objectives: In this study, we aimed to investigate the link between common -2548G>A (rs7799039) promoter variant of the human leptin gene (LEP) with leptin and serum glucose leptin levels in obese Saudi patients. Glucose 181-188 leptin Homo sapiens 154-157 35334523-1 2022 Background and Objectives: In this study, we aimed to investigate the link between common -2548G>A (rs7799039) promoter variant of the human leptin gene (LEP) with leptin and serum glucose leptin levels in obese Saudi patients. Glucose 181-188 leptin Homo sapiens 189-195 33400373-2 2021 Protein tyrosine phosphatase 1B (PTP1B), a negative regulator for insulin and leptin signaling, potentially modulates glucose and energy homeostasis. Glucose 118-125 leptin Homo sapiens 78-84 35355566-11 2022 Serum leptin levels of the patients were correlated with the FSI, fasting plasma glucose (FPG), homeostasis model assessment of insulin resistance (HOMA-IR), body mass index (BMI), and total testosterone levels. Glucose 81-88 leptin Homo sapiens 6-12 32921323-0 2021 Dissimilar regulation of glucose and lipid metabolism by leptin in two strains of gibel carp (Carassius gibelio). Glucose 25-32 leptin Homo sapiens 57-63 32921323-2 2021 As leptin plays a pivotal role in the effects of insulin, we hypothesized that leptin regulation of glucose and lipid metabolism would differ between the two strains. Glucose 100-107 leptin Homo sapiens 79-85 32921323-5 2021 Hypoglycemia induced by leptin might be due to higher glucose uptake by the liver and muscles together with enhanced glycolytic potential and reduced gluconeogenic potential. Glucose 54-61 leptin Homo sapiens 24-30 32921323-12 2021 Overall, the regulation of glucose and lipid metabolism by leptin differed between the two strains, as expected. Glucose 27-34 leptin Homo sapiens 59-65 33728816-0 2021 Maternal glucose in pregnancy is associated with child"s adiposity and leptin at 5 years of age. Glucose 9-16 leptin Homo sapiens 71-77 33728816-9 2021 Higher post-load glucose levels at second trimester were associated with greater total body fat percentage measured by DXA (1 hour-glucose: beta = .010 +- .004; P = .03 and 2 hours-glucose: beta = .016 +- .005; P = .002), but not with leptin levels. Glucose 17-24 leptin Homo sapiens 235-241 33535537-4 2021 Some adipokines, such as leptin, resistin, and visfatin, which are overproduced in obesity and widely implicated in different stages of cancer, promote cellular glucose and lipid metabolism. Glucose 161-168 leptin Homo sapiens 25-31 33150398-0 2021 Tissue-specific effects of leptin on glucose and lipid metabolism. Glucose 37-44 leptin Homo sapiens 27-33 33150398-2 2021 However, the effects of leptin are more far-reaching and include profound glucose-lowering and anti-lipogenic effects, independent of leptin"s regulation of body weight. Glucose 74-81 leptin Homo sapiens 24-30 32416314-4 2020 Second, we discuss brain leptin signalling pathways that impact glucose homeostasis in glucose-deprived and excessed conditions, and propose that leptin enhances hypothalamic glucose sensing and restores glucose homeostasis in short-term high-fat and/or uncontrolled diabetic conditions. Glucose 64-71 leptin Homo sapiens 25-31 32638449-5 2020 Leptin-mediated protection of BBB was further confirmed in vitro, through a BBB cellular model under the in vitro ischemic condition (G/R: Glucose-Oxygen-Serum deprivation followed by GOS restoration). Glucose 139-146 leptin Homo sapiens 0-6 33679095-0 2020 Association of Visceral Adiposity Index, Lipid Profile, and Serum Leptin with Glucose Intolerance Risks in Iraqi Obese Patients: A Cross-sectional Study. Glucose 78-85 leptin Homo sapiens 66-72 32623019-1 2020 BACKGROUND: Leptin and adiponectin are adipose-tissue derived hormones primarily involved in glucose, lipid, and energy metabolism, inflammation, and atherosclerosis. Glucose 93-100 leptin Homo sapiens 12-18 32476508-6 2020 The increase of serum adiponectin level and the decrease of leptin resistance after LRYGB surgery restored the metabolic balance of leptin and adiponectin, improved insulin resistance (IR), and thus improved blood glucose level. Glucose 214-221 leptin Homo sapiens 60-66 32996102-7 2020 Preoperative leptin had a moderate positive correlation with glucose level at the third month (Pearson r = 0.46, P = 0.02), but not with HbA1c. Glucose 61-68 leptin Homo sapiens 13-19 32996102-8 2020 Patients with leptin above 27.34 ng/mL had a higher glucose level at the end of observation (101.9 versus 88.9, t test, P = 0.042). Glucose 52-59 leptin Homo sapiens 14-20 33251850-1 2021 BACKGROUND: Leptin and adiponectin, two adipokines involved in glucose and lipid metabolism, have been linked to regulation of growth in early infancy, energy balance, and metabolic disorders in childhood. Glucose 63-70 leptin Homo sapiens 12-18 32416314-5 2020 MAJOR CONCLUSIONS: In conclusion, we believe basic studies that investigate the interaction of glucose sensing and leptin action in the brain will address the translational impact of hypothalamic glucose sensing in diabetes and obesity. Glucose 95-102 leptin Homo sapiens 115-121 32438270-5 2020 Additionally, leptin signaling was considered because together with insulin, it modulates glucose and lipid homeostasis. Glucose 90-97 leptin Homo sapiens 14-20 32364518-7 2020 Leptin levels were positively correlated with fasting glucose, fasting insulin, free testosterone levels and homeostatic model assessment of insulin resistance (HOMA-IR) values. Glucose 54-61 leptin Homo sapiens 0-6 32451760-1 2020 PURPOSE OF REVIEW: In this brief review, we highlight studies that have contributed to our current understanding of glucose homeostasis by the central nervous system (CNS) leptin-melanocortin system, particularly proopiomelanocortin neurons and melanocortin-4 receptors (MC4R). Glucose 116-123 leptin Homo sapiens 172-178 32451760-6 2020 The powerful antidiabetic actions of the CNS leptin-melanocortin system are capable of normalizing plasma glucose even in the absence of insulin and involve interactions of multiple neuronal populations and intracellular signaling pathways. Glucose 106-113 leptin Homo sapiens 45-51 30185078-12 2020 A positive correlation was found between serum leptin levels with gestational age and insulin levels in preterm infants, and between serum leptin levels and insulin and glucose levels in term infants. Glucose 169-176 leptin Homo sapiens 139-145 32267812-0 2020 Correction to: Regulation of Blood Pressure, Appetite, and Glucose by Leptin After Inactivation of Insulin Receptor Substrate 2 Signaling in the Entire Brain or in Proopiomelanocortin Neurons. Glucose 59-66 leptin Homo sapiens 70-76 31743040-1 2020 The possibility to use leptin therapeutically for lowering glucose levels in patients with type 1 diabetes has attracted interest. Glucose 59-66 leptin Homo sapiens 23-29 32069352-2 2020 Leptin positively correlates with adiposity and has glucose-lowering effects, thus it may mediate the association of early-life nutrition and long-term glycemic status. Glucose 52-59 leptin Homo sapiens 0-6 32069352-12 2020 Leptin mediated 34.9% of the pathway between early-life nutrition and fasting glucose in women. Glucose 78-85 leptin Homo sapiens 0-6 32069352-15 2020 CONCLUSIONS: Leptin mediated the glucose-lowering effect of early-life nutrition in women but not in men. Glucose 33-40 leptin Homo sapiens 13-19 32383705-4 2020 Hormonal changes in T2-D also may increase susceptibility to TB, including 2 hormones -ghrelin and leptin that are involved to in controlling blood glucose levels related to malnutrition during TB. Glucose 148-155 leptin Homo sapiens 99-105 31743040-3 2020 Here, we aim to test glucose-lowering effects of leptin in novel, more human-like murine models. Glucose 21-28 leptin Homo sapiens 49-55 31743040-11 2020 Thus, the potential for a glucose-lowering effect of leptin would already have been attained with standard insulin therapy, and further effects on blood glucose level through additional leptin cannot be anticipated. Glucose 26-33 leptin Homo sapiens 53-59 33408552-5 2020 The aim of this study was to investigate the effect of leptin on the viability and mode of cell death in breast cancer cells incubated in different glucose concentrations to represent caloric restriction. Glucose 148-155 leptin Homo sapiens 55-61 31954015-10 2020 Serum leptin concentration was significantly correlated with body mass index, fasting blood glucose and BMI, FBG and glycated haemoglobin (p<0.001 each). Glucose 92-99 leptin Homo sapiens 6-12 33408552-11 2020 One-hour leptin treatment reverses the effect of low glucose incubation on apoptosis of T47D and necrosis of MCF-7 cells. Glucose 53-60 leptin Homo sapiens 9-15 32566928-0 2019 Effects of different glucose concentrations on the leptin signaling pathway in MCF-7 and T47D breast cancer cells. Glucose 21-28 leptin Homo sapiens 51-57 32566928-4 2019 The aim of this study was to investigate the effect of different glucose concentrations on the leptin signaling pathway in MCF-7 and T47D breast cancer cells. Glucose 65-72 leptin Homo sapiens 95-101 31191220-3 2019 It has been shown that insulin stimulates the production of leptin when adipocytes are exposed to glucose to encourage satiety; while leptin, via a negative feedback, decreases the insulin release and enhances tissue sensitivity to it, leading to glucose uptake for energy utilization or storage. Glucose 98-105 leptin Homo sapiens 60-66 32566928-8 2019 mRNA levels of leptin, ObR, ObRb or STAT3 in 2.5 mM, 5 mM, 25 mM, or 50 mM glucose incubated cells were not significantly different in both cell lines compared to 0 mM (p>0.05). Glucose 75-82 leptin Homo sapiens 15-21 32010873-1 2020 Context and Objective: Leptin treatment has dramatic clinical effects on glucose and lipid metabolism in leptin-deficient patients with lipodystrophy. Glucose 73-80 leptin Homo sapiens 23-29 31379415-6 2019 Leptin, adiponectin, glycoalbumin, and body mass index also were correlated well with plasma glucose levels and insulin resistance index. Glucose 93-100 leptin Homo sapiens 0-6 31191220-3 2019 It has been shown that insulin stimulates the production of leptin when adipocytes are exposed to glucose to encourage satiety; while leptin, via a negative feedback, decreases the insulin release and enhances tissue sensitivity to it, leading to glucose uptake for energy utilization or storage. Glucose 247-254 leptin Homo sapiens 134-140 31336472-8 2019 Serum leptin showed significant positive correlations with diabetes duration (r = 0.188, P = 0.020), glucose (r = 0.298, P < 0.001), cholesterol (r = 0.323, P < 0.001), triglycerides (r = 0.361, P < 0.001), LDL-C (r = 0.248, P = 0.001) and urinary albumin (r = 0.256, P = 0.001) whereas negative significant correlations were found with HDL-C (r = -0.313, P < 0.001) and urinary creatinine (r = -0.202, P = 0.007). Glucose 101-108 leptin Homo sapiens 6-12 30802285-9 2019 Repeated administration of either pegylated hLEP D23L or pegylated hLEP significantly decreased blood glucose levels compared with the control before glucose challenge and after oral glucose tolerance test, but with no difference between the two treatments. Glucose 102-109 leptin Homo sapiens 44-48 30802285-9 2019 Repeated administration of either pegylated hLEP D23L or pegylated hLEP significantly decreased blood glucose levels compared with the control before glucose challenge and after oral glucose tolerance test, but with no difference between the two treatments. Glucose 102-109 leptin Homo sapiens 67-71 30802285-9 2019 Repeated administration of either pegylated hLEP D23L or pegylated hLEP significantly decreased blood glucose levels compared with the control before glucose challenge and after oral glucose tolerance test, but with no difference between the two treatments. Glucose 150-157 leptin Homo sapiens 67-71 30802285-9 2019 Repeated administration of either pegylated hLEP D23L or pegylated hLEP significantly decreased blood glucose levels compared with the control before glucose challenge and after oral glucose tolerance test, but with no difference between the two treatments. Glucose 150-157 leptin Homo sapiens 67-71 31046466-2 2019 It is known that leptin plays an important role in glucose metabolism and mutations in the leptin receptor gene (LEPR) are responsible for different complications in renal transplant recipients. Glucose 51-58 leptin Homo sapiens 17-23 30583468-9 2018 Moreover, G2548A of LEP polymorphism was associated with elevated body mass index (BMI) and fasting blood glucose (FBG) in the case group. Glucose 106-113 leptin Homo sapiens 20-23 29682594-0 2018 The Role of Leptin in Maintaining Plasma Glucose During Starvation. Glucose 41-48 leptin Homo sapiens 12-18 29451987-1 2018 BACKGROUND: Adiponectin and leptin are adipose tissue hormones that regulate important lipid and glucose metabolic pathways. Glucose 97-104 leptin Homo sapiens 28-34 29235553-9 2018 Leptin to adiponectin ratio was significantly associated with fasting plasma GIP levels (beta (95% CI): 0.84 (0.10-1.59)) independently of glucose levels. Glucose 139-146 leptin Homo sapiens 0-6 30098320-0 2018 A mathematical model of type 1 diabetes involving leptin effects on glucose metabolism. Glucose 68-75 leptin Homo sapiens 50-56 30098320-1 2018 Leptin, a hormone released from fat cells in adipose tissues, was recently found to be capable of normalizing glucose metabolism in animals. Glucose 110-117 leptin Homo sapiens 0-6 30098320-2 2018 Clinical data on patients with lipodystrophy indicates that leptin may have a positive effect on glucose metabolism in individuals with diabetes. Glucose 97-104 leptin Homo sapiens 60-66 30333864-2 2018 In order to identify novel therapeutic targets, the present study investigated the effect of leptin and its receptor on glucose metabolism in TCL. Glucose 120-127 leptin Homo sapiens 93-99 30333864-5 2018 In vitro analysis using the human TCL MOLT-3 cell line demonstrated that leptin stimulated cell glucose uptake via promoting recruitment and expression of Glut1, effects which were abolished by ObR-specific small interfering RNA (siRNA). Glucose 96-103 leptin Homo sapiens 73-79 30333864-8 2018 In conclusion, these results suggested that leptin serves a critical role in TCL glucose uptake via the ObR. Glucose 81-88 leptin Homo sapiens 44-50 29748581-7 2018 In vitro, pretreatment of hMSCs with recombinant leptin (hMSCs-Leppre) displayed improved cell survival against severe ischemic condition (glucose and serum deprivation under hypoxia), which was associated with increased mitochondrial fusion. Glucose 139-146 leptin Homo sapiens 49-55 29373433-5 2018 Our results revealed a significant interaction between training and LEP genotype for glucose level. Glucose 85-92 leptin Homo sapiens 68-71 29373433-6 2018 A training-related decrease in plasma glucose concentration in the LEP AG heterozygotes differed significantly from the change in the homozygotes. Glucose 38-45 leptin Homo sapiens 67-70 29373433-12 2018 This study provides evidence that polymorphisms in the LEP and LEPR genes are associated with the magnitude of the effects of regular physical activity on glucose and LDL-C levels, respectively. Glucose 155-162 leptin Homo sapiens 55-58 29682594-4 2018 In addition, leptin may be largely responsible for mediating a shift from a reliance upon glucose metabolism (absorption and glycogenolysis) to fat metabolism (lipolysis increasing gluconeogenesis) which preserves substrates for the brain, heart, and other critical organs. Glucose 90-97 leptin Homo sapiens 13-19 29682594-5 2018 In this way a leptin-mediated glucose-fatty acid cycle appears to maintain glycemia and permit survival in starvation. Glucose 30-37 leptin Homo sapiens 14-20 29111188-2 2017 Leptin circulates freely in blood and controls body weight and food intake mainly through hypothalamic receptors and regulates glucose metabolism in the liver both directly through leptin receptors and indirectly via the hypothalamic receptors of central nervous system. Glucose 127-134 leptin Homo sapiens 0-6 29132244-6 2018 RESULTS: When controlling for age, BMI and glucose, leptin levels were higher in the bipolar disorder manic episode group (BD-ME) and bipolar euthymic episode group (BD-EE) than the control group; resistin levels were higher in the BD-ME compared to the control group and it had a positive correlation with Young Mania Rating Scale (YMRS). Glucose 43-50 leptin Homo sapiens 52-58 29434574-10 2018 Stimulated leptin levels also had significant interactions with insulin sensitivity (homeostasis model of insulin resistance, P = 0.01), triglycerides (P = 0.0078), fasting glucose (P = 0.027), systolic blood pressure (P = 0.037), and high-sensitivity C-reactive protein (P = 0.027). Glucose 173-180 leptin Homo sapiens 11-17 29465157-11 2018 There were significant correlations between leptin and BMI, HOMA-I, waist, glucose, triglycerides and cHDL. Glucose 75-82 leptin Homo sapiens 44-50 30390289-2 2018 Leptin acts on the neurons in certain brain areas such as the hypothalamus, hippocampus, and brain stem to regulate food intake, thermogenesis, energy expenditure, and homeostasis of glucose/lipid metabolism. Glucose 183-190 leptin Homo sapiens 0-6 30267494-1 2018 OBJECTIVE: The aim of the study was to establish the relationship between obesity, glucose and leptin level of 2 type diabetes mellitus patients with metabolic syndrome. Glucose 83-90 leptin Homo sapiens 95-101 29255202-1 2017 Previous studies suggest that leptin (LEP) has an important role in glucose metabolism in the nonpregnant state. Glucose 68-75 leptin Homo sapiens 30-36 29255202-1 2017 Previous studies suggest that leptin (LEP) has an important role in glucose metabolism in the nonpregnant state. Glucose 68-75 leptin Homo sapiens 38-41 29255202-3 2017 This study aimed to analyze the impact of maternal and fetal common LEP variants on glucose homeostasis in the pregnant state. Glucose 84-91 leptin Homo sapiens 68-71 29255202-7 2017 This study provides genetic evidence that both maternal and fetal LEP polymorphisms may affect maternal glucose metabolism in pregnancy. Glucose 104-111 leptin Homo sapiens 66-69 29111188-3 2017 Leptin affects food intake regulation and eventually glucose metabolism, lipometabolism, endocrine and immune functions, reproductive function, adipose tissue metabolism and energy expenditure. Glucose 53-60 leptin Homo sapiens 0-6 29111188-4 2017 Leptin also exerts peripheral effects directly on glucose metabolism and gluconeogenesis. Glucose 50-57 leptin Homo sapiens 0-6 28714862-0 2017 A leptin-regulated circuit controls glucose mobilization during noxious stimuli. Glucose 36-43 leptin Homo sapiens 2-8 28714862-7 2017 Thus, decreased leptin action on PAG LepRb neurons augments the autonomic response to noxious stimuli, ensuring sufficient glucose mobilization during periods of acute demand in the face of diminished energy stores. Glucose 123-130 leptin Homo sapiens 16-22 28685604-4 2017 Recent studies show that potential mediators of insulin resistance such as adipokines - adiponectin, leptin and resistin are important for glucose and lipid metabolism. Glucose 139-146 leptin Homo sapiens 101-107 28944270-2 2017 Additionally, leptin exerts important control on glucose homeostasis, thermogenesis, autonomic nervous system and neuroendocrine axes. Glucose 49-56 leptin Homo sapiens 14-20 28951828-2 2017 Leptin can also independently lower blood glucose levels, particularly in hyperglycemic models of leptin or insulin deficiency. Glucose 42-49 leptin Homo sapiens 0-6 28951828-3 2017 Despite significant efforts and relevance to diabetes, the mechanisms by which leptin acts to regulate blood glucose levels are not fully understood. Glucose 109-116 leptin Homo sapiens 79-85 28951828-4 2017 SCOPE OF REVIEW: Here we assess literature relevant to the glucose lowering effects of leptin. Glucose 59-66 leptin Homo sapiens 87-93 28951828-5 2017 Leptin receptors are widely expressed in multiple cell types, and we describe both peripheral and central effects of leptin that may be involved in lowering blood glucose. Glucose 163-170 leptin Homo sapiens 0-6 28951828-5 2017 Leptin receptors are widely expressed in multiple cell types, and we describe both peripheral and central effects of leptin that may be involved in lowering blood glucose. Glucose 163-170 leptin Homo sapiens 117-123 28951828-7 2017 MAJOR CONCLUSIONS: Leptin exerts a plethora of metabolic effects on various tissues including suppressing production of glucagon and corticosterone, increasing glucose uptake, and inhibiting hepatic glucose output. Glucose 160-167 leptin Homo sapiens 19-25 28951828-8 2017 A more in-depth understanding of the mechanisms of the glucose-lowering actions of leptin may reveal new strategies to treat metabolic disorders. Glucose 55-62 leptin Homo sapiens 83-89 28286536-7 2017 Leptin was a positive predictor of insulin, glucose, HOMA-IR, and HOMA-beta after adjusting for age, sex and percent body fat (all p < 0.001). Glucose 44-51 leptin Homo sapiens 0-6 27677243-2 2016 Overlaps in the regulation of glucose and energy homeostasis have been reported between leptin and insulin. Glucose 30-37 leptin Homo sapiens 88-94 27322922-4 2016 On the other hand, adipose tissue, secreting adipokines such as chemerin, visfatin, leptin, and adiponectin, not only regulates glucose and lipid metabolism, and endothelial cell function regulation, but it may contribute to inflammation. Glucose 128-135 leptin Homo sapiens 84-90 27511061-11 2016 We demonstrated that MCI is associated with lower serum leptin independent of sex, age, body fat, glucose, and lipid metabolism. Glucose 98-105 leptin Homo sapiens 56-62 27877104-18 2016 Endogenous sweet molecules including glucose may regulate energy homeostasis through sweet taste receptors on glucose-and leptin-responsive neurons in the ARC. Glucose 37-44 leptin Homo sapiens 122-128 28436331-10 2017 Both leptin and insulin regulate appetite, body weight, and glucose levels in the body. Glucose 60-67 leptin Homo sapiens 5-11 27340502-10 2016 CONCLUSIONS: These results suggest that maternal glucose in pregnancy could produce variations in DNA methylation in BAT-related genes and that some of these DNA methylation marks seem to mediate the impact of maternal glycemia on cord blood leptin levels, an adipokine regulating body weight. Glucose 49-56 leptin Homo sapiens 242-248 27746736-0 2016 Flurbiprofen Ameliorates Glucose Deprivation-Induced Leptin Resistance. Glucose 25-32 leptin Homo sapiens 53-59 27746736-2 2016 The present study showed that glucose deprivation inhibited leptin-induced phosphorylation of signal transducer and activator of transcription 3 (STAT3) and signal transducer and activator of transcription 5 (STAT5) in neuronal cells. Glucose 30-37 leptin Homo sapiens 60-66 27264884-2 2016 Therefore, the purpose of this study was to test the hypothesis that an acute 1h bout of hyperthermic treatment improves glucose, insulin, and leptin responses to an oral glucose challenge (OGTT) in obese type 2 diabetics and healthy humans. Glucose 171-178 leptin Homo sapiens 143-149 27746736-3 2016 Flurbiprofen reversed glucose deprivation-mediated attenuation of STAT3, but not STAT5 activation, in leptin-treated cells. Glucose 22-29 leptin Homo sapiens 102-108 27746736-6 2016 Flurbiprofen may ameliorate glucose deprivation-induced leptin resistance in neuronal cells. Glucose 28-35 leptin Homo sapiens 56-62 26969486-2 2016 In this review we examine the role of the brain in the glucose-lowering actions of leptin and the potential mediators responsible for driving hyperglycaemia in states of uncontrolled insulin-deficient diabetes (uDM). Glucose 55-62 leptin Homo sapiens 83-89 26873941-1 2016 BACKGROUND: Adiponectin, leptin, and resistin are the most well-studied adipokines and play important roles in the regulation of glucose metabolism, subclinical inflammation, and cardiovascular homeostasis. Glucose 129-136 leptin Homo sapiens 25-31 26957637-5 2016 hLeptin reduced plasma glucose by 9% and hepatic glycogen content by 73%, and these effects were associated with a 17% increase in glucose disposal during an insulin tolerance test. Glucose 23-30 leptin Homo sapiens 0-7 26957637-5 2016 hLeptin reduced plasma glucose by 9% and hepatic glycogen content by 73%, and these effects were associated with a 17% increase in glucose disposal during an insulin tolerance test. Glucose 131-138 leptin Homo sapiens 0-7 27133319-7 2016 Leptin levels correlated positively with anthropometric measurements, triglyceride, fasting glucose, C-reactive protein, and uric acid levels, and negatively with high-density lipoprotein cholesterol levels. Glucose 92-99 leptin Homo sapiens 0-6 27003399-4 2016 Similarly, adiponectin, leptin and IL-6 enhance glucose uptake and increase fatty acid oxidation in skeletal muscle. Glucose 48-55 leptin Homo sapiens 24-30 26772821-9 2016 These results point towards a role of leptin in metabolic reprogramming, consisting of an enhanced use of glucose for biosynthesis and lipids for energy production. Glucose 106-113 leptin Homo sapiens 38-44 26569494-1 2015 Adipose tissue-derived hormone leptin plays a functional role in glucose tolerance through its effects on insulin secretion and insulin sensitivity which also represent the risk factors for nonalcoholic fatty liver disease (NAFLD). Glucose 65-72 leptin Homo sapiens 31-37 26453299-9 2015 The signaling and cellular mechanisms underlying Kv2.1 channel trafficking regulation by leptin mirror those reported recently for ATP-sensitive potassium (KATP) channels, which are critical for coupling glucose stimulation with membrane depolarization. Glucose 204-211 leptin Homo sapiens 89-95 26453299-10 2015 We show that the leptin-induced increase in surface KATP channels results in more hyperpolarized membrane potentials than control cells at stimulating glucose concentrations, and the increase in Kv2.1 channels leads to a more rapid repolarization of membrane potential in cells firing action potentials. Glucose 151-158 leptin Homo sapiens 17-23 25726860-4 2015 AREAS COVERED: The main signaling pathways activated by leptin as well as the mechanisms underlying the regulatory actions of leptin on food intake and on lipid and glucose metabolism are reviewed. Glucose 165-172 leptin Homo sapiens 56-62 25744051-0 2015 Leptin, 20 years of searching for glucose homeostasis. Glucose 34-41 leptin Homo sapiens 0-6 25744051-3 2015 In fact, leptin plays an important role in the regulation of glucose homeostasis independent of food intake and body weight. Glucose 61-68 leptin Homo sapiens 9-15 25744051-4 2015 The mechanism underlying the modulation of glucose metabolism by leptin is not completely understood, although evidence indicates that the effect occurs at both the central and peripheral levels. Glucose 43-50 leptin Homo sapiens 65-71 25744051-5 2015 In this review, we will focus on the role of leptin in glucose homeostasis at the central level and its role in insulin secretion and in counteracting hormones, such as glucagon, growth hormone, cortisol and catecholamines. Glucose 55-62 leptin Homo sapiens 45-51 26071010-1 2015 Leptin regulates glucose, lipid and energy homeostasis as well as feeding behavior, serving as a bridge between peripheral metabolically active tissues and the central nervous system (CNS). Glucose 17-24 leptin Homo sapiens 0-6 26103557-5 2015 Leptin and adiponectin are adipokines strongly associated with glucose and lipid metabolism and with energy balance. Glucose 63-70 leptin Homo sapiens 0-6 26523220-11 2015 Serum leptin level and BMI of AA genotype of A19G was higher than GA and GG genotypes; meanwhile, fasting blood glucose of that genotypes was the highest. Glucose 112-119 leptin Homo sapiens 6-12 26413228-6 2015 Leptin is also an important hormone in the regulation of cardiac metabolism where it supports oxidation of glucose and fatty acids. Glucose 107-114 leptin Homo sapiens 0-6 25726860-4 2015 AREAS COVERED: The main signaling pathways activated by leptin as well as the mechanisms underlying the regulatory actions of leptin on food intake and on lipid and glucose metabolism are reviewed. Glucose 165-172 leptin Homo sapiens 126-132 25367549-3 2015 This retrospective study addressed the effectiveness of recombinant methionyl leptin (metreleptin) for improving glucose metabolism, lipid profile, and hepatic steatosis in patients with genetic lipodystrophic syndromes. Glucose 113-120 leptin Homo sapiens 78-84 25907896-12 2015 In the MetS group, the variation in the adiponectin:leptin ratio was correlated with variations in glucose, insulin sensibility, total cholesterol, LDL-c and systolic blood pressure. Glucose 99-106 leptin Homo sapiens 52-58 25306890-4 2015 The aim of this study was to investigate the effect of physiologic and low pathophysiologic gender-specific leptin concentration found in lean and obese subjects on glucose transport, the expression of glucose transporters and leptin receptors in human peripheral blood lymphocytes. Glucose 165-172 leptin Homo sapiens 108-114 25499980-1 2015 We demonstrated previously an inhibitory effect of luminal leptin on glucose absorption in differentiated Caco-2 cells. Glucose 69-76 leptin Homo sapiens 59-65 25870537-4 2015 Here, we review the neuronal and peripheral mechanisms by which leptin signaling in the central nervous system (CNS) regulates glucose metabolism in an insulin-independent manner. Glucose 127-134 leptin Homo sapiens 64-70 26315697-1 2015 UNLABELLED: Backdround/Aims: The aim of this work was to study the effect and mechanism of action of leptin added apically, on glucose absorption, using Caco-2 cells as a model. Glucose 127-134 leptin Homo sapiens 101-107 25701340-7 2015 Serum leptin had positive and significant indirect effects on men"s ratios of total cholesterol to HDL-C (beta = 0.215) and triacylglycerol to HDL-C (beta = 0.209), as well as fasting glucose (beta = 0.173). Glucose 184-191 leptin Homo sapiens 6-12 26315697-5 2015 Leptin reduced glucose absorption only by day 16 after confluence, the time at which apical leptin receptors started appearing. Glucose 15-22 leptin Homo sapiens 0-6 25267014-1 2015 Leptin is a hormone secreted by adipocytes that regulates energy metabolism via peripheral action on glucose synthesis and utilization as well as through central regulation of food intake. Glucose 101-108 leptin Homo sapiens 0-6 25267014-5 2015 In the much more commonly encountered HIV-associated lipodystrophy, leptin replacement has been shown to decrease central fat mass and to improve insulin sensitivity, dyslipidemia, and glucose levels. Glucose 185-192 leptin Homo sapiens 68-74 26282401-2 2015 Leptin and adiponectin are adipokines and play an important role in the regulation of insulin secretion as well as glucose and lipid metabolism. Glucose 115-122 leptin Homo sapiens 0-6 25273345-6 2014 Higher fasting and postload glucose levels were associated with higher cord-blood levels of insulin and leptin in all participants, irrespective of ethnicity. Glucose 28-35 leptin Homo sapiens 104-110 26556498-3 2015 Leptin is an adipokine which has a fundamental role in glucose and lipid homeostasis. Glucose 55-62 leptin Homo sapiens 0-6 25273345-9 2014 Path analyses supported the hypothesis that fasting glucose levels mediate the relationship of Pakistani ethnicity to greater fat mass at birth, as measured by cord-blood leptin levels; on average, 19% of this mediation involved fetal insulin secretion. Glucose 52-59 leptin Homo sapiens 171-177 25097618-8 2014 Leptin level was correlated with age, fasting blood glucose, BMI, and insulin level. Glucose 52-59 leptin Homo sapiens 0-6 24981337-6 2014 Patients in the upper quartile of leptin levels had high values of BMI, WC, systolic and diastolic blood pressure, glucose, and HOMA index compared with patients with lower leptin levels. Glucose 115-122 leptin Homo sapiens 34-40 24981337-8 2014 Leptin positively correlated with BMI, WC, triglycerides, and glucose concentrations in patients of both sexes. Glucose 62-69 leptin Homo sapiens 0-6 25610316-15 2014 Serum leptin level was significantly correlated with sex, age, primary cause of ESRD, BMI, blood glucose level and duration of peritoneal dialysis (PD). Glucose 97-104 leptin Homo sapiens 6-12 25610316-17 2014 Increased leptin was correlated with sex, age, BMI, primary cause of ESRD and serum glucose level. Glucose 84-91 leptin Homo sapiens 10-16 24075245-11 2014 CONCLUSION: In SAH patients, appetite loss may be induced by lower serum ghrelin and higher serum leptin concentrations resulting from high plasma glucose and insulin levels due to a catecholamine surge following SAH. Glucose 147-154 leptin Homo sapiens 98-104 25327319-2 2014 One of them is leptin, which regulates several critical functions at the central nervous system such as caloric intake, basal energy expenditure, reproduction, glucose and lipid metabolism and osteogenesis. Glucose 160-167 leptin Homo sapiens 15-21 24561183-4 2014 Leptin stimulation of the hypothalamus can stimulate glucose uptake via the sympathetic nervous system in heart, muscle, and brown adipose tissue. Glucose 53-60 leptin Homo sapiens 0-6 24402012-1 2013 OBJECTIVE: The aim of the study was to investigate whether adiposity and metabolic markers, such as leptin, glucose, and lipids, are influenced by leptin (LEP) and leptin receptor (LEPR) gene polymorphisms in a sample of our population. Glucose 108-115 leptin Homo sapiens 147-153 24150199-5 2014 RESULTS: After adjustment for age, gender and BMI, plasma leptin concentrations were positively associated with hsCRP (t=2.72, p=0.009) and fasting plasma glucose (t=4.27, p<0.0001); plasma adiponectin concentrations were negatively associated with hsCRP (t=-3.31, p=0.0016); and positively with high density lipoprotein cholesterol (t=2.32, p=0.02). Glucose 155-162 leptin Homo sapiens 58-64 24150199-6 2014 Children in the highest quartile of leptin/adiponectin (L/A) ratio demonstrated significantly higher BMI, systolic blood pressure, hsCRP, triglycerides and fasting glucose and the lowest high density lipoprotein (HDL) compared to lower L/A ratio quartiles. Glucose 164-171 leptin Homo sapiens 36-42 24340098-2 2013 The aim of this work was to investigate the direct effect of luminal leptin on glucose intestinal absorption and elucidate for the first time its signaling pathway. Glucose 79-86 leptin Homo sapiens 69-75 24340098-10 2013 These results suggest that leptin reduces glucose absorption by activating PKC. Glucose 42-49 leptin Homo sapiens 27-33 24361011-0 2014 Jejunal leptin-PI3K signaling lowers glucose production. Glucose 37-44 leptin Homo sapiens 8-14 24361011-3 2014 We report here that intrajejunal leptin administration activates jejunal leptin receptors and signals through a phosphatidylinositol 3-kinase (PI3K)-dependent and signal transducer and activator of transcription 3 (STAT3)-independent signaling pathway to lower glucose production in healthy rodents. Glucose 261-268 leptin Homo sapiens 33-39 24361011-3 2014 We report here that intrajejunal leptin administration activates jejunal leptin receptors and signals through a phosphatidylinositol 3-kinase (PI3K)-dependent and signal transducer and activator of transcription 3 (STAT3)-independent signaling pathway to lower glucose production in healthy rodents. Glucose 261-268 leptin Homo sapiens 73-79 24361011-4 2014 Jejunal leptin action is sufficient to lower glucose production in uncontrolled diabetic and high-fat-fed rodents and contributes to the early antidiabetic effect of duodenal-jejunal bypass surgery. Glucose 45-52 leptin Homo sapiens 8-14 24361011-5 2014 These data unveil a glucoregulatory site of leptin action and suggest that enhancing leptin-PI3K signaling in the jejunum lowers plasma glucose concentrations in diabetes. Glucose 136-143 leptin Homo sapiens 44-50 24361011-5 2014 These data unveil a glucoregulatory site of leptin action and suggest that enhancing leptin-PI3K signaling in the jejunum lowers plasma glucose concentrations in diabetes. Glucose 136-143 leptin Homo sapiens 85-91 23688014-5 2014 Under physiological condition, leptin is known to reduce appetite, promote energy expenditure, increase sympathetic activity, facilitate glucose utilization and improve insulin sensitivity. Glucose 137-144 leptin Homo sapiens 31-37 24754069-7 2014 The persons in the highest leptin quartile were found to have higher BMI, WC, systolic and diastolic BP (SBP and DBP), and blood glucose levels than those in the lowest quartile. Glucose 129-136 leptin Homo sapiens 27-33 24402012-1 2013 OBJECTIVE: The aim of the study was to investigate whether adiposity and metabolic markers, such as leptin, glucose, and lipids, are influenced by leptin (LEP) and leptin receptor (LEPR) gene polymorphisms in a sample of our population. Glucose 108-115 leptin Homo sapiens 155-158 23823177-0 2013 Circulating leptin and adiponectin and their relation to glucose metabolism in children with Crohn"s disease and ulcerative colitis. Glucose 57-64 leptin Homo sapiens 12-18 24260287-7 2013 Moreover, pJAK2 was almost completely colocalized with leptin receptor under high glucose conditions. Glucose 82-89 leptin Homo sapiens 55-61 23512943-8 2013 The 24-h leptin profiles increased during glucose consumption and decreased during fructose consumption. Glucose 42-49 leptin Homo sapiens 9-15 23512943-10 2013 CONCLUSIONS: The consumption of fructose and glucose beverages induced changes in plasma concentrations of ASP, adiponectin, and leptin. Glucose 45-52 leptin Homo sapiens 129-135 24047926-8 2013 In women, fasting blood glucose changes from baseline to 12 months significantly predicted leptin changes from baseline to 12 months; in men, body mass index changes predicted leptin change. Glucose 24-31 leptin Homo sapiens 91-97 23216672-2 2013 Leptin has been shown to reduce hyperglycaemia in rodent models of type 1 diabetes and has recently been shown to normalize fasting plasma glucose concentrations in a rodent model of polygenic obesity and type 2 diabetes. Glucose 139-146 leptin Homo sapiens 0-6 24772944-8 2013 In patients with glucose levels >100 mg/dl, mean BMI, HOMA-IR, insulin, TG, TC and leptin levels were significantly higher than in patients with glucose levels <100 mg/dl. Glucose 17-24 leptin Homo sapiens 86-92 24772944-11 2013 In cholelithiasis group, there was a positive correlation between leptin and age, BMI, glucose, insulin, TG, TC, LDL-C or HOMA-IR. Glucose 87-94 leptin Homo sapiens 66-72 23751306-2 2013 Previous studies have tested the association of polymorphisms in LEP gene with obesity and obesity-related metabolic biomarkers (anthropometric variables, glucose, insulin level, leptin level and lipid profile). Glucose 155-162 leptin Homo sapiens 65-68 23216672-4 2013 However, short-term human clinical studies in overweight and obese patients with recently diagnosed type 2 diabetes have reported minimal efficacy of leptin administration to lower blood glucose levels. Glucose 187-194 leptin Homo sapiens 150-156 23475416-3 2013 Leptin administration has also been shown to decrease central fat mass and improve insulin sensitivity and fasting insulin and glucose levels in HIV-infected patients with highly active antiretroviral therapy (HAART)-induced lipodystrophy, insulin resistance, and leptin deficiency. Glucose 127-134 leptin Homo sapiens 0-6 23475416-6 2013 In this review, we present a description of leptin biology and signaling; we summarize leptin"s contribution to glucose metabolism in animals and humans in vitro, ex vivo, and in vivo; and we provide insights into the emerging clinical applications and therapeutic uses of leptin in humans with lipodystrophy and/or diabetes. Glucose 112-119 leptin Homo sapiens 87-93 23475416-6 2013 In this review, we present a description of leptin biology and signaling; we summarize leptin"s contribution to glucose metabolism in animals and humans in vitro, ex vivo, and in vivo; and we provide insights into the emerging clinical applications and therapeutic uses of leptin in humans with lipodystrophy and/or diabetes. Glucose 112-119 leptin Homo sapiens 87-93 23025244-3 2012 7h exhibited potent glucose-lowering effects on insulin-resistant HepG2 cells and regulated adiponectin and leptin expression in 3T3-L1 adipocytes. Glucose 20-27 leptin Homo sapiens 108-114 22974102-12 2013 Further, reduced leptin levels after abstinence might be related to improved glucose kinetics in patients with diabetes. Glucose 77-84 leptin Homo sapiens 17-23 23565491-6 2012 Leptin increases glucose uptake in skeletal muscle via the hypothalamic-sympathetic nervous system axis and beta-adrenergic mechanism, while leptin stimulates fatty acid oxidation in muscle via AMP-activated protein kinase (AMPK). Glucose 17-24 leptin Homo sapiens 0-6 23565491-9 2012 Thus, leptin plays an important role in the regulation of glucose and fatty acid metabolism in skeletal muscle. Glucose 58-65 leptin Homo sapiens 6-12 24568074-11 2012 CONCLUSION: It appears that an increased leptin level two hours after the meal is due to increased serum insulin and glucose levels. Glucose 117-124 leptin Homo sapiens 41-47 23266767-11 2013 The net action of leptin is to inhibit appetite, stimulate thermogenesis, enhance fatty acid oxidation, decrease glucose, and reduce body weight and fat. Glucose 113-120 leptin Homo sapiens 18-24 22770668-7 2013 The prandial glucose response was negatively correlated to the BA increase after oral nutrition (r = -.733, p = 0.028) and to the change in leptin during parenteral nutrition (r = -.738, p = 0.037) pointing towards a nutritional route-dependent positive impact on glucose tolerance of both substances. Glucose 13-20 leptin Homo sapiens 140-146 22770668-10 2013 CONCLUSION: Our results suggest a substantial involvement of BA and leptin by improving postprandial glucose tolerance related to liver cirrhosis. Glucose 101-108 leptin Homo sapiens 68-74 23392949-10 2013 Furthermore, the high glucose concentration treatment inhibited the expression of adiponectin and increased the expression of leptin in human adipocytes. Glucose 22-29 leptin Homo sapiens 126-132 23565487-3 2012 Recent evidence suggests, however, that in addition to playing a key role in the regulation of energy homeostasis, the adiposity hormone leptin also plays an important role in the control of glucose metabolism via its actions in the brain. Glucose 191-198 leptin Homo sapiens 137-143 23565487-4 2012 This review examines the role of leptin action in the central nervous system and the mechanisms whereby leptin mediates its effects to regulate glucose metabolism. Glucose 144-151 leptin Homo sapiens 104-110 23565491-0 2012 Regulatory role of leptin in glucose and lipid metabolism in skeletal muscle. Glucose 29-36 leptin Homo sapiens 19-25 23565491-2 2012 Several lines of evidences indicate that independent of the anorexic effect, leptin regulates glucose and lipid metabolism in peripheral tissues in rodents and humans. Glucose 94-101 leptin Homo sapiens 77-83 22948759-7 2012 On univariate correlation analysis, leptin was most strongly associated with prepregnancy body mass index (BMI) (r = 0.54, P < 0.0001), fasting insulin (r = 0.60, P < 0.0001), and C-reactive protein (r = 0.38, P < 0.0001) but only weakly associated with area under the glucose curve (AUC(glucose)) on the OGTT (r = 0.10, P = 0.0066). Glucose 278-285 leptin Homo sapiens 36-42 22948759-7 2012 On univariate correlation analysis, leptin was most strongly associated with prepregnancy body mass index (BMI) (r = 0.54, P < 0.0001), fasting insulin (r = 0.60, P < 0.0001), and C-reactive protein (r = 0.38, P < 0.0001) but only weakly associated with area under the glucose curve (AUC(glucose)) on the OGTT (r = 0.10, P = 0.0066). Glucose 297-304 leptin Homo sapiens 36-42 26894024-9 2012 Plasma leptin levels were positively correlated with body mass index, fasting and postprandial blood glucose, hemoglobin A1c, total cholesterol, urinary albumin excretion, high-sensitivity C-reactive protein (hsCRP), and MCP-1 plasma levels, and negatively correlated with creatinine clearance values. Glucose 101-108 leptin Homo sapiens 7-13 22542724-3 2012 Small or non-randomized studies have suggested that leptin replacement improves glucose metabolism in HADL, with very limited data regarding its effects on the lipid kinetic abnormalities. Glucose 80-87 leptin Homo sapiens 52-58 22542724-12 2012 These results suggest a dissociation between leptin"s effects on glucose metabolism compared to those on lipid kinetics in HADL. Glucose 65-72 leptin Homo sapiens 45-51 22863437-3 2012 METHODS: This is a cross-sectional analysis of adult subjects (n=173, age 45 +- 12 years, 124 women; body mass index [BMI] 35.6 +- 9.5 kg/m(2)) for association of leptin and its soluble receptor with cardiometabolic risk factors (glucose, BMI, waist circumference, hip circumference, blood pressure, insulin, cholesterol and triglycerides). Glucose 230-237 leptin Homo sapiens 163-169 22863437-6 2012 RESULTS: Leptin was positively associated with blood pressure, BMI, waist circumference, hip circumference, triglycerides, glucose, insulin and HOMA and inversely correlated with HDL-cholesterol. Glucose 123-130 leptin Homo sapiens 9-15 22875510-4 2012 RESULTS: Among three groups of individuals with different levels of glucose, the methylation rates of leptin gene in IGR and T2DM groups were 43.6 % and 31.5 %, respectively, which were significantly lower than that of healthy subjects (59.2%; Chi-square=22.499 and 5.109, respectively, P<0.05). Glucose 68-75 leptin Homo sapiens 102-108 22448029-3 2012 Although leptin acts through central and peripheral mechanisms to modulate glucose metabolism, the pancreatic beta-cell of the endocrine pancreas is a critical target of leptin actions. Glucose 75-82 leptin Homo sapiens 9-15 22737657-6 2012 Leptin administration has been shown to decrease central fat mass and to improve fasting insulin/glucose levels and insulin sensitivity in human immunodeficiency virus-infected hypoleptinemic patients with HAART induced lipodystrophy and the metabolic syndrome. Glucose 97-104 leptin Homo sapiens 0-6 22368147-0 2012 The effect of leptin on maturing porcine oocytes is dependent on glucose concentration. Glucose 65-72 leptin Homo sapiens 14-20 22252010-10 2012 CONCLUSION: These data show in human intestinal cells that leptin can rapidly control the activity of physiologically relevant transporters for rich-energy molecules, that is, D-glucose (SGLT1) and amino acids (ASCT2, B(0) AT1 and PAT1). Glucose 176-185 leptin Homo sapiens 59-65 22368147-1 2012 Increased body weight is often accompanied by increased circulating levels of leptin and glucose, which alters glucose metabolism in various tissues, including perhaps the oocyte. Glucose 111-118 leptin Homo sapiens 78-84 22368147-5 2012 We also evaluated the effect of leptin on glucose metabolism via glycolysis and the pentose phosphate pathway. Glucose 42-49 leptin Homo sapiens 32-38 22368147-10 2012 The present study demonstrates that in a physiological glucose concentration, leptin plays a negligible role in oocyte function. Glucose 55-62 leptin Homo sapiens 78-84 22368147-11 2012 However, leptin appears to modulate the deleterious impact of a high glucose environment on oocyte function. Glucose 69-76 leptin Homo sapiens 9-15 21760842-7 2011 Besides, leptin level was positively correlated with waist (r = 0.512, P = 0.03) and neck circumferences (r = 0.547, P = 0.03), and fasting glucose (r = 0.471, P = 0.04) in OSAS patients, but not in obese subjects. Glucose 140-147 leptin Homo sapiens 9-15 21947707-2 2012 Leptin, an essential cytokine regulating food intake, energy expenditure, glucose, and fat metabolism may be part of the mechanistic pathway. Glucose 74-81 leptin Homo sapiens 0-6 21797799-9 2012 After adjusting age, sex, ICH volume and location, fasting blood glucose, fasting insulin levels, and systolic blood pressure (SBP) multivariate analysis showed that a high leptin level (>10 ng/L) was an independent predictor for in hospital mortality (adjusted risk ratio (RR), 3.6; 95% confidence interval (CI): 1.22-17.62; P = 0.02). Glucose 65-72 leptin Homo sapiens 173-179 24843554-4 2012 The mechanisms through which leptin modulates glucose metabolism have not been fully elucidated. Glucose 46-53 leptin Homo sapiens 29-35 22427467-3 2012 Adipokines (adiponectin, leptin), hormones produced by the adipose tissue, change glucose and lipid metabolism, and have an anorectic effect through increasing energy consumption in the hypothalamus. Glucose 82-89 leptin Homo sapiens 25-31 22035595-5 2012 Our data indicated that diabetes as whole was strongly associated with elevated levels of IL-6, leptin, CRP and TNF-alpha, whereas worsening of glucose control was positively and linearly associated with high levels of IL-6, and leptin. Glucose 144-151 leptin Homo sapiens 229-235 21633176-2 2011 Since its discovery, leptin has been found to have profound effects on behavior, metabolic rate, endocrine axes, and glucose fluxes. Glucose 117-124 leptin Homo sapiens 21-27 21445529-1 2011 Adipose tissue secretes a variety of adipokines, including leptin and adiponectin, which are involved in endocrine processes regulating glucose and fatty metabolism, energy expenditure, inflammatory response, immunity, cardiovascular function, and reproduction. Glucose 136-143 leptin Homo sapiens 59-65 20553219-1 2011 OBJECTIVES: The objective of this study was to assess the association of serum leptin levels with insulin resistance (IR), metabolic syndrome (MetS), lipid levels, and glucose control in an Iranian type 2 diabetic population. Glucose 168-175 leptin Homo sapiens 79-85 21609588-0 2011 [Relationship of glucose metabolic rate and plasma levels of adiponectin and leptin in patients with metabolic syndrome]. Glucose 17-24 leptin Homo sapiens 77-83 21609588-10 2011 (3) In MS group, glucose metabolic rate was associated with WC, BMI, TG, HDL-C FINS, leptin, and adiponectin, (all P < 0.05). Glucose 17-24 leptin Homo sapiens 85-91 21374991-11 2010 Leptin was positively correlated with age, BMI, waist, A1c, fasting and OGTT-2h glucose, OGTT-2h TI and TNF-alpha in all subjects, and was negatively correlated with HOMA-B in females. Glucose 80-87 leptin Homo sapiens 0-6 21932576-7 2011 RESULTS: Leptin and adiponectin levels were significantly correlated with anthropometric parameters, HOMA-IR and insulin in all subjects and with fasting glucose in girls only. Glucose 154-161 leptin Homo sapiens 9-15 20724651-5 2010 RESULTS: We have shown that placental leptin gene DNA methylation levels were correlated with glucose levels (2-h post-OGTT) in women with IGT (fetal side: rho=-0.44, P<=0.05; maternal side: rho=0.53, P<=0.01) and with decreased leptin gene expression (n=48; rho>=-0.30, P<=0.05) in the whole cohort. Glucose 94-101 leptin Homo sapiens 38-44 20690892-4 2010 Recent studies have demonstrated the long-term therapeutic effects of central leptin gene therapy in obesity and diabetes via decreased insulin resistance and increased glucose metabolism. Glucose 169-176 leptin Homo sapiens 78-84 20560877-0 2010 Leptin and interleukin-1beta modulate neuronal glutamate release and protect against glucose-oxygen-serum deprivation. Glucose 85-92 leptin Homo sapiens 0-6 20560877-1 2010 Molecular mechanism underlying leptin-mediated neuronal protection against glucose-oxygen-serum deprivation (GOSD) insult was investigated by focusing on the interactions among leptin, Interleukin-1beta (IL-1beta) and glutamate and their impacts on the growth of neurons under GOSD. Glucose 75-82 leptin Homo sapiens 31-37 18927166-1 2010 Leptin and adiponectin represent two newly discovered adipose tissue derived hormones; that are both associated with health status and glucose and free fatty acid (FFA) metabolism. Glucose 135-142 leptin Homo sapiens 0-6 21215066-9 2010 In men, leptin was also significantly associated with the increase of diastolic blood pressure and glucose but decreased with high-density lipoprotein cholesterol (P from 0.03 to 0.02). Glucose 99-106 leptin Homo sapiens 8-14 20401706-7 2010 We observed negative correlation between serum leptin and fasting glucose levels and HDL-cholesterol levels were found to be non-significant among the groups. Glucose 66-73 leptin Homo sapiens 47-53 20377141-5 2010 Significant correlation was observed between glucose and leptin concentrations. Glucose 45-52 leptin Homo sapiens 57-63 19727896-3 2010 AIMS OF THE STUDY: Objective of the study was to evaluate if aberrations in glucose metabolism during pregnancy are related to leptin concentration and whether serum leptin concentration is affected by diet composition. Glucose 76-83 leptin Homo sapiens 127-133 19727896-11 2010 CONCLUSIONS: Overweight-related elevation in serum leptin is associated with impaired regulation of glucose metabolism during pregnancy. Glucose 100-107 leptin Homo sapiens 51-57 20429700-2 2010 glucose bolus on insulin, leptin, ghrelin, peptide YY (PYY), free fatty acids (FFA), glucagon and glucagon-like peptide-1 (GLP-1) concentrations together with self-reported satiety ratings in lean and obese human subjects. Glucose 0-7 leptin Homo sapiens 26-32 19681034-3 2009 We sought to describe leptin changes after a 75 g oral glucose tolerance test (OGTT) in women with a prior diagnosis of gestational diabetes mellitus (a high risk group for the metabolic syndrome) compared to that in healthy controls. Glucose 55-62 leptin Homo sapiens 22-28 20093782-5 2010 The plasma leptin level and sweet taste sensitivity are proposed to link with post-ingestive plasma glucose level. Glucose 100-107 leptin Homo sapiens 11-17 19596030-8 2009 After glucose load, a significant decrease in leptin appeared in both GHD groups, but not in the control group. Glucose 6-13 leptin Homo sapiens 46-52 19596030-12 2009 Leptin regulation after glucose load is impaired in GHD, whereas ghrelin regulation seems to be not effected. Glucose 24-31 leptin Homo sapiens 0-6 19681034-8 2009 Postload (90 min) leptin levels decreased significantly in women with normal glucose tolerance by 13% (95% CI 8-18%), while no significant change in postload leptin level was apparent in women with abnormal glucose tolerance (3% increase, 95% CI -4% to 29%). Glucose 77-84 leptin Homo sapiens 18-24 19176740-1 2009 Leptin has emerged over the past decade as a key hormone in not only the regulation of food intake and energy expenditure but also in the regulation of neuroendocrine and immune function as well as the modulation of glucose and fat metabolism as shown by numerous observational and interventional studies in humans with (complete) congenital or relative leptin deficiency. Glucose 216-223 leptin Homo sapiens 0-6 18359113-11 2009 The higher leptin levels in women was accompanied by higher serum levels of glucose, albumin, Ca, cholesterol, Na and FT4. Glucose 76-83 leptin Homo sapiens 11-17 18953507-9 2009 There were positive correlations for body weight-fasting glucose and body weight-leptin (p < 0.05), body weight-BMI and body weight-LBM (p < 0.01); body fat-leptin (p < 0.05); BMI-fasting glucose, BMI-leptin, and BMI-body fat (p < 0.05); albumin-hemoglobin and albumin-insulin (p < 0.05). Glucose 57-64 leptin Homo sapiens 81-87 19730134-3 2009 Humans with genetic mutations in the leptin and leptin receptor genes have deregulated food intake and energy expenditure leading to a morbidly obese phenotype and a disrupted regulation in neuroendocrine and immune function and in glucose and fat metabolism. Glucose 232-239 leptin Homo sapiens 37-43 19730134-3 2009 Humans with genetic mutations in the leptin and leptin receptor genes have deregulated food intake and energy expenditure leading to a morbidly obese phenotype and a disrupted regulation in neuroendocrine and immune function and in glucose and fat metabolism. Glucose 232-239 leptin Homo sapiens 48-54 24591860-0 2009 Investigation of the correlation between 100 gram oral glucose tolerance test results and maternal leptin levels during pregnancy. Glucose 55-62 leptin Homo sapiens 99-105 19169663-8 2009 In this model mouse mimicking human type 2 diabetes (STZ/HFD), continuous leptin infusion reduced food intake and body weight and improved glucose and lipid metabolism with enhancement of insulin sensitivity. Glucose 139-146 leptin Homo sapiens 74-80 19181412-4 2009 The correlation coefficients of MetS components except fasting glucose with leptin were similar to those with L/A and higher than those with adiponectin. Glucose 63-70 leptin Homo sapiens 76-82 19320933-0 2009 Increased plasma leptin through l-carnitine supplementation is associated with an enhanced glucose tolerance in healthy ponies. Glucose 91-98 leptin Homo sapiens 17-23 18180784-5 2008 RESULTS: In longitudinal analyses adjusted for CVD risk factors and leptin at the previous menopausal stage, aging, education, smoking and physical activity, greater increases in leptin over the menopause transition were associated with greater decreases in high-density lipoprotein cholesterol (HDL-c) and greater increases in diastolic blood pressure, glucose, insulin and insulin resistance (all P < 0.05). Glucose 354-361 leptin Homo sapiens 179-185 19144201-0 2009 Serum leptin concentrations are not related to dietary patterns but are related to sex, age, body mass index, serum triacylglycerol, serum insulin, and plasma glucose in the US population. Glucose 159-166 leptin Homo sapiens 6-12 19144201-9 2009 Sex, age, BMI, serum triacylglycerol, plasma glucose, and serum insulin are independent predictors of serum leptin concentrations. Glucose 45-52 leptin Homo sapiens 108-114 20049263-1 2009 AIM: To investigate the relationship between serum leptin, atherogenic lipid and glucose levels in patients with skin tags and healthy controls. Glucose 81-88 leptin Homo sapiens 51-57 18263705-0 2008 Glucose and leptin induce apoptosis in human beta-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases. Glucose 67-74 leptin Homo sapiens 12-18 18414479-2 2008 Also, the administration of leptin lowers blood glucose levels in some rodent models of diabetes and in humans with lipodystrophy. Glucose 48-55 leptin Homo sapiens 28-34 18564365-2 2008 Leptin inhibits the glucose-stimulated insulin secretion, and leptin receptors are present on beta cells as well as on fat cells, thus enabling leptin to modulate both insulin secretion and action. Glucose 20-27 leptin Homo sapiens 0-6 18564365-2 2008 Leptin inhibits the glucose-stimulated insulin secretion, and leptin receptors are present on beta cells as well as on fat cells, thus enabling leptin to modulate both insulin secretion and action. Glucose 20-27 leptin Homo sapiens 144-150 18564365-3 2008 Therefore, leptin (LEP) and leptin receptor (LEPR) genes could play a role in the regulation of glucose and insulin after an oral glucose load. Glucose 96-103 leptin Homo sapiens 11-17 18564365-3 2008 Therefore, leptin (LEP) and leptin receptor (LEPR) genes could play a role in the regulation of glucose and insulin after an oral glucose load. Glucose 96-103 leptin Homo sapiens 19-22 18379533-6 2008 In 3T3-L1 adipocytes, glucose-based PD4 1.36% significantly increased leptin secretion vs amino-acid-based (AA) and icodextrin (ICOD)-based PD fluids. Glucose 22-29 leptin Homo sapiens 70-76 18202144-5 2008 Leptin also controls glucose and lipid metabolism by targeting enzymes such as AMP-activated protein kinase and stearoyl-coenzyme A desaturase-1 in liver and muscle. Glucose 21-28 leptin Homo sapiens 0-6 18468820-8 2008 During OGTT, in both groups, leptin concentration increased significantly and fasting glucose predicts significantly serum leptin change; there was no change in adiponectin, resistin and sOB-R concentrations. Glucose 86-93 leptin Homo sapiens 123-129 18468820-11 2008 Leptin secretion is acutely regulated by glucose levels in insulin presence. Glucose 41-48 leptin Homo sapiens 0-6 18379533-8 2008 Glucose concentration in PD fluids was shown to determine leptin secretion. Glucose 0-7 leptin Homo sapiens 58-64 18379533-9 2008 Preliminary data from PD patients showed that a single 6-h dwell with PD4 3.86% glucose acutely increased plasma leptin vs AA (P<0.05). Glucose 80-87 leptin Homo sapiens 113-119 18379533-10 2008 The reduction in glucose load in a standard PD regimen was associated with an improvement in the plasma leptin/adiponectin ratio at 6 months. Glucose 17-24 leptin Homo sapiens 104-110 18379533-14 2008 In PD patients, hypertonic glucose-based PD fluids may increase plasma leptin levels. Glucose 27-34 leptin Homo sapiens 71-77 18004125-0 2007 Ghrelin and leptin response to oral glucose challenge among antipsychotic drug-treated children. Glucose 36-43 leptin Homo sapiens 12-18 18053615-4 2008 Furthermore, the leptin insufficiency syndrome delineates a novel role of leptin in the hypothalamus in restraining rhythmic pancreatic insulin secretion while concomitantly enhancing glucose metabolism and non-shivering thermogenic energy expenditure, sequelae that would otherwise promote fat accrual to store excess energy resulting from consumption of energy-enriched diets. Glucose 184-191 leptin Homo sapiens 17-23 18004125-9 2007 Findings encourage further oral glucose tolerance test studies to explain the leptin response to weight gain seen among children receiving antipsychotic medication. Glucose 32-39 leptin Homo sapiens 78-84 17132702-9 2007 High glucose PD fluids (4.25%) specifically inhibited leptin secretion vs 1.5% glucose, buffer-matched solutions (P < 0.05). Glucose 5-12 leptin Homo sapiens 54-60 18225446-6 2007 Glucose sensing can be modulated by other nutrients (particularly fatty acids) and also by hormones (insulin, leptin and ghrelin) and peptides (NPY). Glucose 0-7 leptin Homo sapiens 110-116 17311679-5 2007 RESULTS: Circulating leptin was reduced 2 h after glucose uptake whereas adiponectin and resistin levels are not changed. Glucose 50-57 leptin Homo sapiens 21-27 17311679-8 2007 CONCLUSION: Taken together our data indicate that only leptin is reduced by glucose uptake in insulin-sensitive probands whereas adiponectin and resistin are not altered. Glucose 76-83 leptin Homo sapiens 55-61 18651469-7 2007 Leptin levels correlated positively with all anthropometric measurements, fasting glucose, triglyceride levels, CRP and uric acid and negatively with HDL-cholesterol. Glucose 82-89 leptin Homo sapiens 0-6 17118991-3 2007 RESULTS: The leptin-replacement therapy with the twice-daily injection dramatically improved fasting glucose (mean +/- SE, 172 +/- 20 to 120 +/- 12 mg/dl, P < 0.05) and triglyceride levels (mean +/- SE, 700 +/- 272 to 260 +/- 98 mg/dl, P < 0.05) within 1 wk. Glucose 101-108 leptin Homo sapiens 13-19 17118991-4 2007 The leptin-replacement therapy reduced insulin resistance evaluated by euglycemic clamp method and augmented insulin secretion at glucose tolerance test with different responses between acquired and congenital types. Glucose 130-137 leptin Homo sapiens 4-10 16690177-10 2006 glucose supply rates (P<0.05) were independently associated to leptin levels. Glucose 0-7 leptin Homo sapiens 66-72 17160220-7 2006 Circulating glucose 30 (p< 0.01) and 60 (p< 0.05) minutes after ingestion of HSD were positively correlated with postprandial leptin concentration. Glucose 12-19 leptin Homo sapiens 132-138 17142136-3 2006 By simple regression, leptin correlated positively with fat and lean masses, glucose, triglycerides, low-density lipoprotein cholesterol, and total cholesterol, and negatively with high-density lipoprotein cholesterol. Glucose 77-84 leptin Homo sapiens 22-28 16690177-11 2006 CONCLUSIONS: TPN-especially glucose-induces a neurohumoral response as shown here for leptin and insulin that is mainly depending on the fat mass. Glucose 28-35 leptin Homo sapiens 86-92 16898570-2 2006 Hypothalamic centers involved in the regulation of energy balance and endogenous glucose production constantly sense fuel availability by receiving and integrating inputs from circulating nutrients and hormones such as insulin and leptin. Glucose 81-88 leptin Homo sapiens 231-237 16919546-1 2006 We previously reported that the adiponectin-leptin (A/L) ratio was more efficacious as a parameter of insulin resistance than adiponectin or leptin alone, and a more sensitive and reliable marker of insulin resistance than homeostasis model assessment (HOMA-R) as the fasting plasma glucose (FPG) level elevated in type 2 diabetes mellitus. Glucose 283-290 leptin Homo sapiens 44-50 16778577-6 2006 Finally, numerous data have demonstrated the modulation of glucose sensing by other nutrients, in particular fatty acids, hormones (insulin, leptin and ghrelin) and peptides (neuropeptide Y). Glucose 59-66 leptin Homo sapiens 141-147 16497805-0 2006 Insulin and leptin induce Glut4 plasma membrane translocation and glucose uptake in a human neuronal cell line by a phosphatidylinositol 3-kinase- dependent mechanism. Glucose 66-73 leptin Homo sapiens 12-18 16611834-5 2006 Mutation of Ser-318 to alanine abrogates the inhibitory effect of leptin on insulin-induced Irs1 tyrosine phosphorylation and glucose uptake in L6 myoblasts. Glucose 126-133 leptin Homo sapiens 66-72 16641931-7 2006 The leptin receptor expression in mesothelial cells was upregulated by glucose but not leptin. Glucose 71-78 leptin Homo sapiens 4-10 16641931-8 2006 In adipocytes, glucose increased the mRNA expression and synthesis of leptin. Glucose 15-22 leptin Homo sapiens 70-76 16641931-11 2006 The TGF-beta synthesis induced by leptin was amplified by glucose through increased leptin receptor expression. Glucose 58-65 leptin Homo sapiens 34-40 16756630-0 2006 Leptin and resistin levels and their relationships with glucose metabolism in children with chronic renal insufficiency and undergoing dialysis. Glucose 56-63 leptin Homo sapiens 0-6 16497805-8 2006 Chronic exposure of neuronal cells to insulin or leptin down-regulates Glut4 proteins and mRNA levels and abolishes the acute stimulation of glucose uptake in response to acute insulin or leptin. Glucose 141-148 leptin Homo sapiens 49-55 16497805-4 2006 We show that insulin and leptin both induce Glut4 translocation to the PM of neuronal cells and activate glucose uptake. Glucose 105-112 leptin Homo sapiens 25-31 16497805-8 2006 Chronic exposure of neuronal cells to insulin or leptin down-regulates Glut4 proteins and mRNA levels and abolishes the acute stimulation of glucose uptake in response to acute insulin or leptin. Glucose 141-148 leptin Homo sapiens 188-194 16497805-5 2006 Wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase, totally abolished insulin- and leptin-dependent Glut4 translocation and stimulation of glucose uptake. Glucose 154-161 leptin Homo sapiens 98-104 16210367-2 2006 Because the central administration of leptin is capable of preventing the inhibitory effects of fasting on TRH mRNA in hypophysiotropic neurons primarily through effects on the arcuate nucleus, we determined whether the continuous administration of 30 mU/d insulin or 648 microg/d glucose into the cerebrospinal fluid by osmotic minipump might also have similar effects on the hypothalamic-pituitary-thyroid axis. Glucose 281-288 leptin Homo sapiens 38-44 16236542-4 2006 Insulin and glucose appear to increase leptin secretion. Glucose 12-19 leptin Homo sapiens 39-45 16236542-13 2006 This review summarizes the clinical applications of leptin, particularly emphasizing the effects of leptin on glucose homeostasis. Glucose 110-117 leptin Homo sapiens 52-58 16236542-13 2006 This review summarizes the clinical applications of leptin, particularly emphasizing the effects of leptin on glucose homeostasis. Glucose 110-117 leptin Homo sapiens 100-106 16487244-6 2006 There was a positive association between leptin and hs-CRP, sIL-6R and plasma glucose in all patients. Glucose 78-85 leptin Homo sapiens 41-47 16210367-6 2006 We conclude that insulin and glucose only partially replicate the central effects of leptin and may not be essential components of the hypothalamic-pituitary-thyroid regulatory system during fasting. Glucose 29-36 leptin Homo sapiens 85-91 15741239-3 2005 Insulin doubled leptin secretion in the presence of glucose (5 mM), but not in its absence. Glucose 52-59 leptin Homo sapiens 16-22 16316365-0 2005 Acute plasma ghrelin and leptin responses to oral feeding or intraperitoneal hypertonic glucose-based dialysate in patients with chronic renal failure. Glucose 88-95 leptin Homo sapiens 25-31 16316365-2 2005 The aim of this study was to analyze the acute effects of oral feeding or intraperitoneal 3.86% glucose-based dialysate infusion on plasma ghrelin and leptin levels in patients with CRF undergoing peritoneal dialysis (PD). Glucose 96-103 leptin Homo sapiens 151-157 16030519-0 2005 Direct metabolic regulation in skeletal muscle and fat tissue by leptin: implications for glucose and fatty acids homeostasis. Glucose 90-97 leptin Homo sapiens 65-71 16030519-4 2005 Skeletal muscle and adipose tissue, two major tissues involved in the regulation of glucose and fatty acids metabolism, have been consistently demonstrated to be directly affected by leptin. Glucose 84-91 leptin Homo sapiens 183-189 16821211-3 2005 OBJECTIVE: The aim of this study was to define the precise influence of the glucose tolerance status on plasma leptin in obese boys and girls separately. Glucose 76-83 leptin Homo sapiens 111-117 16821211-8 2005 In a multiple regression analysis adjusting for age and adiposity, in the female group plasma glucose and insulin levels 2-h after glucose load were the best predictors of fasting plasma leptin (r=-0.49, p<.005 and r=0.34, p<.05; respectively). Glucose 94-101 leptin Homo sapiens 187-193 16821211-8 2005 In a multiple regression analysis adjusting for age and adiposity, in the female group plasma glucose and insulin levels 2-h after glucose load were the best predictors of fasting plasma leptin (r=-0.49, p<.005 and r=0.34, p<.05; respectively). Glucose 131-138 leptin Homo sapiens 187-193 16821211-9 2005 In boys, plasma insulin level 2-h after glucose load was the independent determinant of leptin (r=0.36, p<.05). Glucose 40-47 leptin Homo sapiens 88-94 16817145-3 2005 OBJECTIVE: The aim of this study was to define the precise influence of the glucose tolerance status on plasma leptin in obese boys and girls separately. Glucose 76-83 leptin Homo sapiens 111-117 16817145-8 2005 In a multiple regression analysis adjusting for age and adiposity, in the female group plasma glucose and insulin levels 2-h after glucose load were the best predictors of fasting plasma leptin (r=-0.49, p<.005 and r=0.34, p<.05; respectively). Glucose 94-101 leptin Homo sapiens 187-193 16817145-8 2005 In a multiple regression analysis adjusting for age and adiposity, in the female group plasma glucose and insulin levels 2-h after glucose load were the best predictors of fasting plasma leptin (r=-0.49, p<.005 and r=0.34, p<.05; respectively). Glucose 131-138 leptin Homo sapiens 187-193 16817145-9 2005 In boys, plasma insulin level 2-h after glucose load was the independent determinant of leptin (r=0.36, p<.05). Glucose 40-47 leptin Homo sapiens 88-94 15741239-8 2005 Interestingly, these five amino acids potently increased basal and insulin-stimulated leptin secretion in the presence of glucose. Glucose 122-129 leptin Homo sapiens 86-92 15741239-6 2005 L-Glycine or L-alanine mimicked the effect of glucose on basal leptin secretion but completely prevented stimulation by insulin. Glucose 46-53 leptin Homo sapiens 63-69 15741239-7 2005 On the other hand, insulin stimulated leptin secretion when glucose was replaced by L-aspartate, L-valine, L-methionine, or L-phenylalanine, but not by L-leucine (all 5 mM). Glucose 60-67 leptin Homo sapiens 38-44 15814535-0 2005 Glucose-containing peritoneal dialysis fluids regulate leptin secretion from 3T3-L1 adipocytes. Glucose 0-7 leptin Homo sapiens 55-61 18370722-11 2005 Leptin was significantly correlated to BMI, fat mass, waist circumference, HOMA-IR, and insulin but not to other components of MS, such as fasting plasma glucose, blood pressure, HDL-cholesterol, triglyceride, and CRP levels. Glucose 154-161 leptin Homo sapiens 0-6 15814535-3 2005 The current study was designed to test if glucose-based PD fluids might regulate leptin production in vitro. Glucose 42-49 leptin Homo sapiens 81-87 15814535-9 2005 CONCLUSIONS: These results suggest that the PD-induced hyperleptinaemia could, in part, be mediated by the effect of glucose-based dialysis fluids on leptin production by adipocytes via activation of the hexosamine biosynthetic pathway. Glucose 117-124 leptin Homo sapiens 60-66 15814535-5 2005 RESULTS: The high glucose-based commercial dialysate PD4 produced a higher leptin secretion compared with an identical laboratory-manufactured dialysate (Lab-D), but with a physiological glucose concentration of 5 mM (P<0.05). Glucose 18-25 leptin Homo sapiens 75-81 15814535-6 2005 Raising glucose concentration from 2.75 to 40 mM in Lab-D induced a dose-dependent increase in leptin secretion of <or=110+/-12% at 48 h (P<0.001) and leptin mRNA (P<0.05; glucose 2.75 vs 40 mM). Glucose 8-15 leptin Homo sapiens 95-101 15814535-6 2005 Raising glucose concentration from 2.75 to 40 mM in Lab-D induced a dose-dependent increase in leptin secretion of <or=110+/-12% at 48 h (P<0.001) and leptin mRNA (P<0.05; glucose 2.75 vs 40 mM). Glucose 8-15 leptin Homo sapiens 157-163 15814535-6 2005 Raising glucose concentration from 2.75 to 40 mM in Lab-D induced a dose-dependent increase in leptin secretion of <or=110+/-12% at 48 h (P<0.001) and leptin mRNA (P<0.05; glucose 2.75 vs 40 mM). Glucose 181-188 leptin Homo sapiens 95-101 15814535-7 2005 Inhibition of UDP-N-acetylglucosamine biosynthesis, with 6-diazo-5-oxo-norleucine added to Lab-D, abolished most of the glucose-stimulated leptin release and downregulated leptin gene expression. Glucose 120-127 leptin Homo sapiens 139-145 15814535-7 2005 Inhibition of UDP-N-acetylglucosamine biosynthesis, with 6-diazo-5-oxo-norleucine added to Lab-D, abolished most of the glucose-stimulated leptin release and downregulated leptin gene expression. Glucose 120-127 leptin Homo sapiens 172-178 15814535-8 2005 Furthermore, glucose-free Lab-D supplemented with 1 mM glucosamine, an intermediate product in UDP-N-acetylglucosamine biosynthesis, increased leptin secretion by 28+/-11% over control (P<0.05), although without effect on leptin mRNA, after 48 h of culture. Glucose 13-20 leptin Homo sapiens 143-149 15814535-8 2005 Furthermore, glucose-free Lab-D supplemented with 1 mM glucosamine, an intermediate product in UDP-N-acetylglucosamine biosynthesis, increased leptin secretion by 28+/-11% over control (P<0.05), although without effect on leptin mRNA, after 48 h of culture. Glucose 13-20 leptin Homo sapiens 225-231 15952665-11 2005 The relationships between plasma glucose, insulin, blood lipids and serum leptin are affected by gender. Glucose 33-40 leptin Homo sapiens 74-80 15840309-7 2005 (2) The serum leptin concentration of the glucose intolerant pregnant women ranged from (11.3 +/- 3.1) microg/L to(14.5 +/- 4.3) microg/L, and showed no difference among different gestational weeks (P > 0.05). Glucose 42-49 leptin Homo sapiens 14-20 15840309-8 2005 (3) Serum leptin level of glucose intolerant women was (12.5 +/- 3.5) microg/L on average, much higher than that of NGT group, (8.5 +/- 2.6) microg/L (P < 0.05), and this difference remained in any gestational week (P < 0.05). Glucose 26-33 leptin Homo sapiens 10-16 15840309-10 2005 Moreover, 64.7% of women whose serum leptin level was above 17.0 microg/L had different degree of glucose intolerance. Glucose 98-105 leptin Homo sapiens 37-43 15840309-12 2005 CONCLUSION: Serum leptin level is correlated with glucose tolerance during pregnancy. Glucose 50-57 leptin Homo sapiens 18-24 15752952-9 2005 In the insulin-sensitive group regardless of BMI, plasma leptin levels decreased after glucose loading. Glucose 87-94 leptin Homo sapiens 57-63