PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11443193-4 2001 Therefore, the relationship between LEPR polymorphisms and glucose and insulin response to an oral glucose tolerance test (OGTT) was investigated. Glucose 59-66 leptin receptor Homo sapiens 36-40 33443255-6 2021 However, gene expression of GHRL, LEPR and ADIPOR1 showed a marked increase following the ingestion of glucose compared with lipids and proteins, regardless of obesity and sex steroids. Glucose 103-110 leptin receptor Homo sapiens 34-38 11443193-3 2001 The leptin receptor (LEPR) gene could thus play a role in the regulation of glucose and insulin after an oral glucose load. Glucose 76-83 leptin receptor Homo sapiens 4-19 11443193-3 2001 The leptin receptor (LEPR) gene could thus play a role in the regulation of glucose and insulin after an oral glucose load. Glucose 76-83 leptin receptor Homo sapiens 21-25 10764974-0 2000 Effect of cerebroventricular infusion of insulin and (or) glucose on hypothalamic expression of leptin receptor and pituitary secretion of LH in diet-restricted ewes. Glucose 58-65 leptin receptor Homo sapiens 96-111 10764974-1 2000 The objective was to determine the effect of central infusion of insulin and (or) glucose on hypothalamic expression of leptin receptor and pituitary secretion of LH in the ewe. Glucose 82-89 leptin receptor Homo sapiens 120-135 10764974-8 2000 Leptin receptor mRNA expression was dramatically reduced (P<0.0002) in INS+GLU versus aCSF treated ewes. Glucose 78-81 leptin receptor Homo sapiens 0-15 10490782-1 1999 OBJECTIVE: To investigate the relationship between polymorphisms in the OB-R and OB genes and metabolic markers for obesity and glucose intolerance in a population of Nauruan men. Glucose 128-135 leptin receptor Homo sapiens 72-76 11798646-2 1999 METHODS: The genotypes of Gln223Arg variant in leptin receptor gene were determined by polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) assay in 359 unrelated subjects of Shanghai "Han" population (including 193 subjects with normal glucose tolerance and 166 type II diabetic patients). Glucose 263-270 leptin receptor Homo sapiens 47-62 34341568-4 2021 Selective deletion of LepR in tanycytes blocks leptin entry into the brain, inducing not only increased food intake and lipogenesis but also glucose intolerance through attenuated insulin secretion by pancreatic beta-cells, possibly via altered sympathetic nervous tone. Glucose 141-148 leptin receptor Homo sapiens 22-26 32566928-9 2019 However, ObR protein levels in MCF-7 cells incubated in 25 mM glucose was significantly lower compared to 0 mM glucose by western blot (p<0.05). Glucose 62-69 leptin receptor Homo sapiens 9-12 32566928-9 2019 However, ObR protein levels in MCF-7 cells incubated in 25 mM glucose was significantly lower compared to 0 mM glucose by western blot (p<0.05). Glucose 111-118 leptin receptor Homo sapiens 9-12 29373433-12 2018 This study provides evidence that polymorphisms in the LEP and LEPR genes are associated with the magnitude of the effects of regular physical activity on glucose and LDL-C levels, respectively. Glucose 155-162 leptin receptor Homo sapiens 63-67 30333864-5 2018 In vitro analysis using the human TCL MOLT-3 cell line demonstrated that leptin stimulated cell glucose uptake via promoting recruitment and expression of Glut1, effects which were abolished by ObR-specific small interfering RNA (siRNA). Glucose 96-103 leptin receptor Homo sapiens 194-197 30333864-8 2018 In conclusion, these results suggested that leptin serves a critical role in TCL glucose uptake via the ObR. Glucose 81-88 leptin receptor Homo sapiens 104-107 26233872-7 2015 CONCLUSIONS: The LEPR Gln223 is associated with obesity, lipid parameters, and plasma glucose in all subjects, with weight, body mass index, and systolic and diastolic blood pressure only in obese subjects, but showed no association with leptin, insulin, and HOMA-IR in a Pakistani study group. Glucose 86-93 leptin receptor Homo sapiens 17-21 28596541-1 2017 Recent studies suggested that maternal and placental leptin receptor (LEPR) may be involved in maternal glucose metabolism in pregnancy. Glucose 104-111 leptin receptor Homo sapiens 53-68 28596541-1 2017 Recent studies suggested that maternal and placental leptin receptor (LEPR) may be involved in maternal glucose metabolism in pregnancy. Glucose 104-111 leptin receptor Homo sapiens 70-74 28596541-2 2017 To identify maternal and fetal LEPR common variants influencing gestational glycemic traits, we performed association study of 24-28-week maternal fasting glucose, glucose 1 hour after the consumption of a 50-g oral glucose load, fasting insulin and indices of beta-cell function (HOMA-beta) and insulin resistance (HOMA-IR) in 1,112 unrelated women and their children. Glucose 155-162 leptin receptor Homo sapiens 31-35 28596541-2 2017 To identify maternal and fetal LEPR common variants influencing gestational glycemic traits, we performed association study of 24-28-week maternal fasting glucose, glucose 1 hour after the consumption of a 50-g oral glucose load, fasting insulin and indices of beta-cell function (HOMA-beta) and insulin resistance (HOMA-IR) in 1,112 unrelated women and their children. Glucose 164-171 leptin receptor Homo sapiens 31-35 28596541-2 2017 To identify maternal and fetal LEPR common variants influencing gestational glycemic traits, we performed association study of 24-28-week maternal fasting glucose, glucose 1 hour after the consumption of a 50-g oral glucose load, fasting insulin and indices of beta-cell function (HOMA-beta) and insulin resistance (HOMA-IR) in 1,112 unrelated women and their children. Glucose 164-171 leptin receptor Homo sapiens 31-35 28596541-3 2017 Follow-up of 36 LEPR loci identified 3 maternal loci (rs10889567, rs1137101 and rs3762274) associated with fasting glucose, these 3 fetal loci associated with fasting insulin and HOMA1-IR, as well as these 3 maternal-fetal loci combinations associated with HOMA2-beta. Glucose 115-122 leptin receptor Homo sapiens 16-20 29090554-0 2017 [Puerariae Lobatae Radix elevated expression levels of OB-R, IRS2, GLUT1 and GLUT2 to regulate glucose metabolism in insulin-resistance HepG2 cells]. Glucose 95-102 leptin receptor Homo sapiens 55-59 18564365-3 2008 Therefore, leptin (LEP) and leptin receptor (LEPR) genes could play a role in the regulation of glucose and insulin after an oral glucose load. Glucose 96-103 leptin receptor Homo sapiens 28-43 25223902-0 2014 A genome-wide association study identifies a LEPR gene as a novel predisposing factor for childhood fasting plasma glucose. Glucose 115-122 leptin receptor Homo sapiens 45-49 24444121-9 2014 Significant associations of LEPR Gln223Arg polymorphism were found with leptin and glucose levels (p < 0.05), after adjusting for potential covariates. Glucose 83-90 leptin receptor Homo sapiens 28-32 22293279-15 2012 CONCLUSIONS: LEPR polymorphisms may be a marker for susceptibility to essential hypertension in Chinese subjects, and be involved in the development of several features including dyslipidemia and impaired glucose regulation in hypertension subjects. Glucose 205-212 leptin receptor Homo sapiens 13-17 21931325-1 2012 OBJECTIVE: Adipocytokine genes encoding adiponectin (ADIPOQ) and the leptin receptor (LEPR) affect glucose and fatty acid metabolism. Glucose 99-106 leptin receptor Homo sapiens 69-84 21931325-1 2012 OBJECTIVE: Adipocytokine genes encoding adiponectin (ADIPOQ) and the leptin receptor (LEPR) affect glucose and fatty acid metabolism. Glucose 99-106 leptin receptor Homo sapiens 86-90 21931325-8 2012 In addition, fasting glucose levels were also significantly different among different genotypes at the SNP rs1892534 in LEPR (P=0.038). Glucose 21-28 leptin receptor Homo sapiens 120-124 22530350-11 2012 CONCLUSION: Lys656Asn polymorphism of LEPR gene is associated with obesity parameters, insulin resistance and glucose levels in patients with NAFLD. Glucose 110-117 leptin receptor Homo sapiens 38-42 18564365-3 2008 Therefore, leptin (LEP) and leptin receptor (LEPR) genes could play a role in the regulation of glucose and insulin after an oral glucose load. Glucose 96-103 leptin receptor Homo sapiens 45-49 18413223-5 2008 OBJECTIVE: The objective of this study was to investigate the influence of Lys656Asn polymorphism in the LEPR gene on serum insulin, glucose values, and insulin resistance in the fasted state among obese men and women without diabetes mellitus. Glucose 133-140 leptin receptor Homo sapiens 105-109 16641931-7 2006 The leptin receptor expression in mesothelial cells was upregulated by glucose but not leptin. Glucose 71-78 leptin receptor Homo sapiens 4-19 16641931-11 2006 The TGF-beta synthesis induced by leptin was amplified by glucose through increased leptin receptor expression. Glucose 58-65 leptin receptor Homo sapiens 84-99 15919835-6 2005 Interaction effects between PTPN1 and leptin receptor gene variants influenced insulin sensitivity index and AIR(glucose) (p from 0.006 to 0.010). Glucose 113-120 leptin receptor Homo sapiens 38-53