PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28928674-10 2017 The metabolic response of glucose during adrenergic stimulation with adrenaline is associated to the G16R polymorphism of ADRB2, although without effect on cerebral metabolism. Glucose 26-33 adrenoceptor beta 2 Homo sapiens 122-127 23657252-0 2013 beta2-Adrenoceptor-mediated regulation of glucose uptake in skeletal muscle--ligand-directed signalling or a reflection of system complexity? Glucose 42-49 adrenoceptor beta 2 Homo sapiens 0-18 26652903-4 2016 In this study, we demonstrate that sustained betaAR stimulation resulted in the inhibition of insulin-induced glucose uptake, and a reduction of insulin induced glucose transporter (GLUT)4 expression that were mediated by the beta2AR subtype in cardiomyocytes and heart tissue. Glucose 110-117 adrenoceptor beta 2 Homo sapiens 45-51 26652903-6 2016 Additionally, betaAR mediated cardiac insulin resistance by reducing glucose uptake and GLUT4 expression via the cAMP-dependent and protein kinase A-dependent pathways. Glucose 69-76 adrenoceptor beta 2 Homo sapiens 14-20 25943853-0 2015 Higenamine 4"-O-beta-d-glucoside in the lotus plumule induces glucose uptake of L6 cells through beta2-adrenergic receptor. Glucose 62-69 adrenoceptor beta 2 Homo sapiens 97-122 25150579-2 2014 We tested whether acute beta2-adrenoceptor stimulation increased insulin-induced glucose uptake in human forearm skeletal muscle. Glucose 81-88 adrenoceptor beta 2 Homo sapiens 24-42 24322328-3 2014 METHODS: The ADRB2 rs1042714 SNP and obesity-related metabolic traits including blood pressure, total cholesterol, triglyceride, fasting glucose, waist circumference, and body mass index (BMI) were examined in 967 individuals with general health examinations. Glucose 137-144 adrenoceptor beta 2 Homo sapiens 13-18 28256297-2 2017 Conversely, activation of betaAR regulates cardiac glucose uptake and promotes insulin resistance (IR) in HF. Glucose 51-58 adrenoceptor beta 2 Homo sapiens 26-32 25012253-10 2015 The results of this study show that acute AG administration has a synergic effect with beta2-adrenergic receptor activation by SALBU on blood glucose increase, suggesting that their pharmacological hyperglycemic action takes place via different mechanisms. Glucose 142-149 adrenoceptor beta 2 Homo sapiens 87-112 23657252-5 2013 in this issue of the journal addresses the capacity of agonists acting at the beta2-adrenoceptor to engender signalling bias in relation to glucose uptake in isolated skeletal muscle, an area of considerable potential interest in targeting insulin-independent pathways for the treatment of type 2 diabetes. Glucose 140-147 adrenoceptor beta 2 Homo sapiens 78-96 22399228-4 2012 In astrocytes, beta2-adrenergic receptor promotes glucose uptake through GLUT1 and accelerates glycogen degradation via coupling to Gs and second messenger cAMP-dependent pathway. Glucose 50-57 adrenoceptor beta 2 Homo sapiens 15-40 24087806-10 2013 Nebulised beta-2 adrenoceptor agonists can augment the effects of intravenous insulin and glucose pending more definitive management of the recurrent hyperkalaemia risk. Glucose 90-97 adrenoceptor beta 2 Homo sapiens 10-29 19620130-9 2009 In the same cell type, transgenic beta(2)AR overexpression causes GRK2 accumulation associated with significant deficit of IRS1 activation and glucose uptake by Ins. Glucose 143-150 adrenoceptor beta 2 Homo sapiens 34-43 21883150-6 2012 Truncation of the C-terminus of the beta(2)-adrenoceptor at position 349 to remove known phosphorylation sites for GPCR kinases (GRKs) or at position 344 to remove an additional PKA site together with the GRK phosphorylation sites did not significantly affect cAMP accumulation but decreased beta(2)-adrenoceptor-stimulated glucose uptake. Glucose 324-331 adrenoceptor beta 2 Homo sapiens 36-56 22013013-14 2011 These observations suggest that B2AR agonists might have therapeutic benefit in diabetic patients with defective glucose counterregulation. Glucose 113-120 adrenoceptor beta 2 Homo sapiens 32-36 20829805-2 2011 We examined the hypothesis that ADRB2 Arg16Gly-Gln27Glu haplotype is associated with body composition, glucose tolerance, and insulin sensitivity in obese, postmenopausal women. Glucose 103-110 adrenoceptor beta 2 Homo sapiens 32-37 20829805-5 2011 We found that ADRB2 haplotype was independently associated with % body fat, abdominal fat distribution, VO(2(max)), insulin sensitivity (M/DeltaInsulin), and glucose tolerance (ANOVA, P < 0.05 for all). Glucose 158-165 adrenoceptor beta 2 Homo sapiens 14-19 20829805-10 2011 This suggests that ADRB2 haplotypes may mediate insulin action, glucose tolerance, and potentially risk for type 2 diabetes mellitus (T2DM) in obese, postmenopausal women. Glucose 64-71 adrenoceptor beta 2 Homo sapiens 19-24 21883150-7 2012 Furthermore, inhibition of GRK by transfection of the betaARKct construct inhibited beta(2)-adrenoceptor-mediated glucose uptake and GLUT4 translocation, and overexpression of a kinase-dead GRK2 mutant (GRK2 K220R) also inhibited GLUT4 translocation. Glucose 114-121 adrenoceptor beta 2 Homo sapiens 84-104 18719028-3 2008 Under physiological glucose environment (100 mg/dl), beta2AR stimulation prevented doxorubicin-induced apoptosis, which was attenuated by cotreatment with wortmannin, a phosphoinositide 3-kinase (PI3K) inhibitor, or transfection of a dominant-negative Akt. Glucose 20-27 adrenoceptor beta 2 Homo sapiens 53-60 18046311-6 2008 Inhibition of glucose transport by cytochalasin B, phloretin, or phlorizin also interfered with beta(3)-AR-mediated memory enhancement 20 min posttraining, whereas inhibition of glycogenolysis interfered with beta(2)-AR agonist enhancement of memory. Glucose 14-21 adrenoceptor beta 2 Homo sapiens 209-219 18719028-8 2008 High ambient glucose (450 mg/dl) caused two major effects: 1) it significantly reduced betaAR-induced PDGFR phosphorylation, Src kinase activity, and activation of PI3K signaling pathway; and 2) it partially attenuated beta2AR-induced antiapoptotic effect. Glucose 13-20 adrenoceptor beta 2 Homo sapiens 219-226 18719028-10 2008 High ambient glucose significantly attenuates beta2AR-mediated cardioprotection by suppressing factors involved in this cascade including PDGFR, Src, and PI3K/Akt. Glucose 13-20 adrenoceptor beta 2 Homo sapiens 46-53 15297801-7 2004 We conclude that downregulation of beta2-adrenoceptor densities on lymphocytes occurs as a result of recurrent hypoglycemia defined as glucose levels of < 2.75 mmol/l. Glucose 135-142 adrenoceptor beta 2 Homo sapiens 35-53 15126009-1 2004 Adrenaline plays a major role in the maintenance of blood glucose level by promoting glycogenolysis during prolonged exercise predominantly via the beta2 adrenergic receptor (beta2AR). Glucose 58-65 adrenoceptor beta 2 Homo sapiens 148-173 15126009-1 2004 Adrenaline plays a major role in the maintenance of blood glucose level by promoting glycogenolysis during prolonged exercise predominantly via the beta2 adrenergic receptor (beta2AR). Glucose 58-65 adrenoceptor beta 2 Homo sapiens 175-182 17077128-7 2007 We observed nominal significant associations of genotype with increased area under the serum insulin curve during an oral glucose tolerance test (P = 0.03) and elevated fasting plasma glucose (P = 0.02) in homozygous Ala92 allele carriers, the latter strengthened by epistasis with the ADRB2 Gly16Arg variant in a double recessive model (P = 0.004). Glucose 184-191 adrenoceptor beta 2 Homo sapiens 286-291 15554460-12 2004 CONCLUSION: Our family-based study provided the first evidence that ADRB2 R16G polymorphism may play an important role in DBP response to benazepril treatment, although the magnitude of the effect appears to be modified by other risk factors such as plasma lipid and glucose profiles. Glucose 267-274 adrenoceptor beta 2 Homo sapiens 68-73 29066136-3 2017 Glucose uptake of muscle cells are known to be induced through beta2AR activation. Glucose 0-7 adrenoceptor beta 2 Homo sapiens 63-70 33584143-13 2021 On the other hand, rs1042714 genotypes do not associate with any abnormality except the homozygous GG have higher triglycerides and lower HDL-C. Interestingly, glucose showed different correlation patterns in individuals carrying different genotypes of the two studied SNP, indicating clearly that the metabolic responses to a normal nutrient are significantly influenced by the genotypes of the SNPs in ADRB2. Glucose 160-167 adrenoceptor beta 2 Homo sapiens 404-409 30834155-1 2019 beta2-Adrenergic receptor (beta2-AR) is implicated in muscle metabolic activities such as glycogen metabolism, glucose uptake, lipolysis and muscle growth. Glucose 111-118 adrenoceptor beta 2 Homo sapiens 0-25 30834155-1 2019 beta2-Adrenergic receptor (beta2-AR) is implicated in muscle metabolic activities such as glycogen metabolism, glucose uptake, lipolysis and muscle growth. Glucose 111-118 adrenoceptor beta 2 Homo sapiens 27-35 29757443-2 2018 Of the common adrenoceptor beta-2 receptor gene (ADRB2) polymorphisms, the Arg16 allele is associated with receptor downregulation and reduced agonist-mediated endogenous glucose production. Glucose 171-178 adrenoceptor beta 2 Homo sapiens 49-54 12824951-7 2003 The blood glucose and insulin concentration during OGTT and blood FFA and TG level during OLTT was lower in patients with the Glu/Glu b2-AR polymorphism than Glu/Gln and Gln/Gln. Glucose 10-17 adrenoceptor beta 2 Homo sapiens 134-139 12832031-6 2003 The ADRB2 Glu27Glu subjects had lower plasma glycerol levels (P = 0.026), while plasma triglycerides (P <0.001) and the insulin:glucose ratio were higher (P = 0.046) as compared to the Gln27Gln group along the peak oxygen consumption trial intervention. Glucose 131-138 adrenoceptor beta 2 Homo sapiens 4-9 11288039-6 2001 The frequency of the beta(2)-AR gene (Gln27Glu) variant tended to increase with worsening of glucose tolerance, but the differences were not statistically significant. Glucose 93-100 adrenoceptor beta 2 Homo sapiens 21-31 1663446-0 1991 Lack of beta 2-adrenoceptor induced long-acting effect on glucose tolerance in type 2 diabetic patients. Glucose 58-65 adrenoceptor beta 2 Homo sapiens 8-27