PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
6270145-2	1981	Addition of glucose to cultured chick embryo hepatocytes caused a concentration-dependent impairment of phenobarbital-mediated induction of delta-aminolevulinate (ALA) synthase resembling the "glucose effect" observed in rodents in vivo.	Glucose	12-19	5'-aminolevulinate synthase 1	Gallus gallus	140-176	
6270145-4	1981	Fructose, glycerol, and lactate mimicked the inhibitory glucose effect on ALA synthase induction, whereas 2-deoxyglucose and 3-O-methylglucose augmented the induction evoked by phenobarbital.	Glucose	56-63	5'-aminolevulinate synthase 1	Gallus gallus	74-86	
6270145-5	1981	2-Deoxyglucose reversed the effect of glucose, glycerol, and lactate on ALA synthase induction suggesting that the glucose effect is mediated by free glucose or glucose 6-phosphate or a nonglycolytic metabolite of glucose 6-phosphate.	Glucose	7-14	5'-aminolevulinate synthase 1	Gallus gallus	72-84	
6270145-5	1981	2-Deoxyglucose reversed the effect of glucose, glycerol, and lactate on ALA synthase induction suggesting that the glucose effect is mediated by free glucose or glucose 6-phosphate or a nonglycolytic metabolite of glucose 6-phosphate.	Glucose	38-45	5'-aminolevulinate synthase 1	Gallus gallus	72-84	
6270145-5	1981	2-Deoxyglucose reversed the effect of glucose, glycerol, and lactate on ALA synthase induction suggesting that the glucose effect is mediated by free glucose or glucose 6-phosphate or a nonglycolytic metabolite of glucose 6-phosphate.	Glucose	38-45	5'-aminolevulinate synthase 1	Gallus gallus	72-84	
6270145-7	1981	However, this inhibitory effect or glucose was reversible by the addition of exogenous heme or ALA suggesting that the primary target of the glucose effect is ALA synthase induction and not synthesis of apocytochrome P-450.	Glucose	141-148	5'-aminolevulinate synthase 1	Gallus gallus	159-171	
6270145-8	1981	Glucagon and dibutyryl cAMP enhanced the induction of ALA synthase and cytochrome P-450 by phenobarbital and partially counteracted the glucose effect on both enzymes suggesting that the glucose effect may be mediated by changes in cAMP levels.	Glucose	187-194	5'-aminolevulinate synthase 1	Gallus gallus	54-66