PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19539008-1 2009 We found alpha-glucosidase inhibitory (alpha-GI) effect of metal ions and their complexes which showed the high blood glucose lowering effect in diabetic model animals. Glucose 118-125 sucrase isomaltase (alpha-glucosidase) Mus musculus 9-26 20799969-2 2010 Treatment of postprandial hyperglycemia can be achieved by inhibiting intestinal alpha-glucosidase, the key enzyme for oligosaccharide digestion and further glucose absorption. Glucose 157-164 sucrase isomaltase (alpha-glucosidase) Mus musculus 81-98 20051258-7 2010 In addition, ACE as a mixed-type inhibitor inhibited alpha-glucosidase activity in vitro with an IC(50) of 0.41 microg/ml, and 100mg/kg of it clearly reduced the increase of blood glucose levels after 5 g/kg amylum loading in normal mice. Glucose 180-187 sucrase isomaltase (alpha-glucosidase) Mus musculus 53-70 15802852-1 2005 We found alpha-glucosidase inhibitory effect of Zn(II) complex with 6-methyl-2-picolinmethylamide (6mpa-ma) which showed the highest blood glucose lowering effect in Zn(II) complexes with picolinamide derivatives in KK-A(y) mice. Glucose 139-146 sucrase isomaltase (alpha-glucosidase) Mus musculus 9-26 17506980-10 2007 Reduction of glucose fluctuation by alpha-glucosidase inhibitor efficiently controlled the progression of atherosclerosis. Glucose 13-20 sucrase isomaltase (alpha-glucosidase) Mus musculus 36-53 16794329-3 2006 Taken together, these results suggest that the inhibitory effect of PsEx on alpha-glucosidase activity might contribute to delay in carbohydrate digestion and subsequent lowering of the blood glucose level, thereby leading to prevention and cure of diabetes. Glucose 192-199 sucrase isomaltase (alpha-glucosidase) Mus musculus 76-93 16713445-12 2006 alpha-Glucosidase inhibitor-inhibitable increases in total intestinal absorptive capacity for sugars were due to carbohydrate-induced increases in V(max) of glucose transport. Glucose 157-164 sucrase isomaltase (alpha-glucosidase) Mus musculus 0-17 16510136-0 2006 Control of plasma glucose with alpha-glucosidase inhibitor attenuates oxidative stress and slows the progression of heart failure in mice. Glucose 18-25 sucrase isomaltase (alpha-glucosidase) Mus musculus 31-48 32722136-4 2020 The potential as alpha-glucosidase inhibitors of products was evaluated with oral sucrose and lactose tolerance (OSTT and OLTT, respectively) and intestinal sucrose hydrolysis (ISH) tests; the potential as SGLT-1 inhibitors was evaluated using oral glucose tolerance (OGTT), intestinal glucose absorption (IGA), and urinary glucose excretion (UGE) tests. Glucose 249-256 sucrase isomaltase (alpha-glucosidase) Mus musculus 17-34 7506286-0 1993 Islet glucan-1,4-alpha-glucosidase: differential influence on insulin secretion induced by glucose and isobutylmethylxanthine in mice. Glucose 91-98 sucrase isomaltase (alpha-glucosidase) Mus musculus 17-34 35066100-3 2022 We used 2-deoxyglucose (2DG) as a glycolysis inhibitor and acarbose (ACA), a specific alpha-glucosidase inhibitor, to decrease glucose uptake. Glucose 127-134 sucrase isomaltase (alpha-glucosidase) Mus musculus 86-103 2434278-3 1986 We found that the increase in insulin secretion during a 4 hr incubation period in the presence of 16.7 mM glucose was accompanied by an increase in islet activities of the lysosomal enzymes acid amyloglucosidase and acid alpha-glucosidase. Glucose 107-114 sucrase isomaltase (alpha-glucosidase) Mus musculus 222-239 7827783-8 1994 Islets cultured in 2 g/l glucose showed elevated insulin response under basal and stimulating conditions during 2-3 wk, followed by a dramatic drop in insulin secretion [Day 7: bIS, 19.5 +/- 5.7 microU/50 microliters; sIS, 80.9 +/- 10.7 microU/50 microliters. Glucose 25-32 sucrase isomaltase (alpha-glucosidase) Mus musculus 218-221 7827783-11 1994 At 11 g/l glucose, functional and morphological islet alterations were accelerated [Day 7: bIS, 10.3 +/- 2.7 microU/50 microliters; sIS, 18.8 +/- 4.9 microU/50 microliters. Glucose 10-17 sucrase isomaltase (alpha-glucosidase) Mus musculus 132-135 32599415-6 2020 A correlative relationship was found between glucose absorption from a cornstarch test feeding given at d 7 and jejunal alpha-glucosidase and sucrase activities (R2 = 0.64; 0.67). Glucose 45-52 sucrase isomaltase (alpha-glucosidase) Mus musculus 120-137 32034442-0 2020 The glucose-lowering effects of alpha-glucosidase inhibitor require a bile acid signal in mice. Glucose 4-11 sucrase isomaltase (alpha-glucosidase) Mus musculus 32-49 32034442-1 2020 AIMS/HYPOTHESIS: Bile-acid (BA) signalling is crucial in metabolism homeostasis and has recently been found to mediate the therapeutic effects of glucose-lowering treatments, including alpha-glucosidase inhibitor (AGI). Glucose 146-153 sucrase isomaltase (alpha-glucosidase) Mus musculus 185-202 28132506-1 2017 Inhibition of alpha-glucosidase and alpha-amylase decreases postprandial blood glucose levels and delays glucose absorption, making it a treatment strategy for type 2 diabetes. Glucose 79-86 sucrase isomaltase (alpha-glucosidase) Mus musculus 14-31 31698833-0 2019 Structure-Activity Relationship Study of Acyclic Terpenes in Blood Glucose Levels: Potential alpha-Glucosidase and Sodium Glucose Cotransporter (SGLT-1) Inhibitors. Glucose 67-74 sucrase isomaltase (alpha-glucosidase) Mus musculus 93-110 29027933-14 2017 Further studies on PLT showed that the substances in PLT ME could reduce the level of mouse postprandial blood glucose through inhibiting the activity of alpha-glucosidase. Glucose 111-118 sucrase isomaltase (alpha-glucosidase) Mus musculus 154-171 28132506-1 2017 Inhibition of alpha-glucosidase and alpha-amylase decreases postprandial blood glucose levels and delays glucose absorption, making it a treatment strategy for type 2 diabetes. Glucose 105-112 sucrase isomaltase (alpha-glucosidase) Mus musculus 14-31 27383805-2 2017 We previously reported that lignosulfonic acid suppresses the rise in blood glucose levels through the inhibition of alpha-glucosidase activity and intestinal glucose absorption. Glucose 76-83 sucrase isomaltase (alpha-glucosidase) Mus musculus 117-134 24823880-2 2014 In the present study we extended our recent findings to evaluate whether alpha-glucosidase inhibitor arginyl-fructose (AF) lowers blood glucose level in diabetic db/db mice, a genetic model for type 2 diabetes. Glucose 136-143 sucrase isomaltase (alpha-glucosidase) Mus musculus 73-90