PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
14578299-8	2003	NAD(P)H oxidase components p47phox, p67phox, and p22phox was overexpressed during both stable and intermittent high glucose.	Glucose	116-123	cytochrome b-245 alpha chain	Homo sapiens	49-56	
32339204-0	2020	Decorin inhibits glucose-induced lens epithelial cell apoptosis via suppressing p22phox-p38 MAPK signaling pathway.	Glucose	17-24	cytochrome b-245 alpha chain	Homo sapiens	80-87	
32339204-9	2020	P22phox and phospho-p38 MAPK were upregulated in high glucose treated HLEB3 cells.	Glucose	54-61	cytochrome b-245 alpha chain	Homo sapiens	0-7	
32339204-10	2020	Knocking down p22phox or p38 by siRNAs can reduce high glucose induced cell apoptosis and oxidative stress level.	Glucose	55-62	cytochrome b-245 alpha chain	Homo sapiens	14-21	
32339204-12	2020	Decorin can inhibit the apoptosis, oxidative stress level and the induction of p22phox and phospho-p38 of HLEB3 induced by high glucose.	Glucose	128-135	cytochrome b-245 alpha chain	Homo sapiens	79-86	
32339204-14	2020	CONCLUSIONS: Results showed that p22phox-p38 pathway may be participated in high glucose induced lens epithelial cell injury, decorin may inhibit the high glucose induced apoptosis and oxidative stress injury by suppressing this pathway in part.	Glucose	81-88	cytochrome b-245 alpha chain	Homo sapiens	33-40	
25879533-9	2015	Intermittent but not constant high glucose strikingly up-regulated the expression of p22phox, an NADPH oxidase component, increasing superoxide.	Glucose	35-42	cytochrome b-245 alpha chain	Homo sapiens	85-92	
25879533-10	2015	The small interfering RNA of p22phox undermined the increase in SA-beta-gal activity induced by intermittent high glucose.	Glucose	114-121	cytochrome b-245 alpha chain	Homo sapiens	29-36	
20890878-5	2011	RESULTS: High-glucose treatment (4x10-2 mol/L) significantly increased NAG release, angiotensin II concentrations in cell lysates and 8-OHdG and p22phox protein levels compared with those in regular glucose medium (1.75x10(-2) mol/L).	Glucose	14-21	cytochrome b-245 alpha chain	Homo sapiens	145-152	
20890878-6	2011	ARBs (candesartan, olmesartan or valsartan; 1x10(-9)-10(-7) mol/L) showed a significant reduction in high-glucose-induced NAG, 8-OHdG and p22phox protein levels in RPTECs.	Glucose	106-113	cytochrome b-245 alpha chain	Homo sapiens	138-145	
20393598-6	2010	Furthermore, the enhanced production of superoxide anion (O2-), increased NADPH oxidase activity, and enhanced expression of p22phox and p47phox proteins induced by high glucose were restored to control levels by losartan, BQ123, and BQ788.	Glucose	170-177	cytochrome b-245 alpha chain	Homo sapiens	125-132	
22268370-7	2012	In addition, multiple and logistic regression analysis demonstrated that the CYBA C242T polymorphism was associated with glucose levels, waist circumference, obesity and diabetes mellitus in hypertensive patients independently of potential confounders.	Glucose	121-128	cytochrome b-245 alpha chain	Homo sapiens	77-81	
18841076-6	2008	In addition, rLE suppressed expression of PKCbeta2 and activation of NADPH oxidase subunit of p22phox promoted by high glucose.	Glucose	119-126	cytochrome b-245 alpha chain	Homo sapiens	94-101	
18390927-6	2008	This premature p47phox translocation and preassembly with p22phox were also observed in HL-60 cells cultured with high glucose (HG; 25 mM) and with the specific ligand for the receptor for advanced glycation end products (RAGE), S100B.	Glucose	119-126	cytochrome b-245 alpha chain	Homo sapiens	58-65