PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28467934-0 2017 PPARdelta Promotes Running Endurance by Preserving Glucose. Glucose 51-58 peroxisome proliferator activator receptor delta Mus musculus 0-9 29409330-7 2018 The bacterial therapy led to up-regulation of lipolytic transcription factors, such as peroxisome proliferator-activated receptor (PPAR)-alpha, PPAR-delta, and their regulated gene products in fatty acid metabolism and glucose uptake, such as acyl-CoA oxidase, carnitine palmitoyl-transferase-1, uncoupling protein-3 and glucose transporter-4. Glucose 219-226 peroxisome proliferator activator receptor delta Mus musculus 144-154 29233935-6 2018 Finally, GW501516-activated PPARdelta improved insulin signaling and glucose intolerance in mice fed a high-fat diet through its interaction with TCPTP45. Glucose 69-76 peroxisome proliferator activator receptor delta Mus musculus 28-37 29351550-11 2018 CONCLUSIONS: This work provides evidence that the PPAR-beta/delta agonist ameliorated metabolic disorders through enhanced beta-oxidation and better tolerance to glucose, whereas the PPAR-alpha agonism was confirmed as a promising therapeutic target for treating metabolic diseases via beige cell induction and enhanced thermogenesis. Glucose 162-169 peroxisome proliferator activator receptor delta Mus musculus 50-59 28467934-5 2017 By preserving systemic glucose levels, PPARdelta acts to delay the onset of hypoglycemia and extends running time by ~100 min in treated mice. Glucose 23-30 peroxisome proliferator activator receptor delta Mus musculus 39-48 28467934-6 2017 Collectively, these results identify a bifurcated PPARdelta program that underlies glucose sparing and highlight the potential of PPARdelta-targeted exercise mimetics in the treatment of metabolic disease, dystrophies, and, unavoidably, the enhancement of athletic performance. Glucose 83-90 peroxisome proliferator activator receptor delta Mus musculus 50-59 27930695-9 2016 A cross talk between ischemia-induced angiogenesis and glucose tolerance pathways was analyzed by Ingenuity Pathway Analysis (IPA) which suggested an interaction of VEGF-A/VEGFR-2 and peroxisome proliferator-activated receptor delta (PPARdelta)/peroxisome proliferator-activated receptor gamma (PPARgamma) genes. Glucose 55-62 peroxisome proliferator activator receptor delta Mus musculus 184-232 27930695-9 2016 A cross talk between ischemia-induced angiogenesis and glucose tolerance pathways was analyzed by Ingenuity Pathway Analysis (IPA) which suggested an interaction of VEGF-A/VEGFR-2 and peroxisome proliferator-activated receptor delta (PPARdelta)/peroxisome proliferator-activated receptor gamma (PPARgamma) genes. Glucose 55-62 peroxisome proliferator activator receptor delta Mus musculus 234-243 24011070-6 2013 Taken together, our data suggest a mechanism whereby miR-199a~214 actively represses cardiac PPARdelta expression, facilitating a metabolic shift from predominant reliance on fatty acid utilization in the healthy myocardium toward increased reliance on glucose metabolism at the onset of heart failure. Glucose 253-260 peroxisome proliferator activator receptor delta Mus musculus 93-102 25728706-3 2015 Feeding PPARbeta/delta-deficient mice with fructose exacerbated glucose intolerance and led to macrophage infiltration, inflammation, enhanced mRNA and protein levels of CD36, and activation of the JNK pathway in white adipose tissue compared to those of water-fed PPARbeta/delta-deficient mice. Glucose 64-71 peroxisome proliferator activator receptor delta Mus musculus 8-16 25279796-4 2014 PPARbeta(-/-) mice have reduced metabolic activity and are glucose intolerant. Glucose 59-66 peroxisome proliferator activator receptor delta Mus musculus 0-8 25279796-12 2014 Taken together, these data indicate that PPARbeta deficiency leads to glucose intolerance, decreased muscle function, and reduced bone strength. Glucose 70-77 peroxisome proliferator activator receptor delta Mus musculus 41-49 24107399-1 2013 Peroxisome proliferator-activated receptors gamma (PPARgamma) and delta (PPARdelta) are nuclear receptors that have significant physiological effects on glucose and lipid metabolism. Glucose 153-160 peroxisome proliferator activator receptor delta Mus musculus 73-82 23954156-5 2013 PPARdelta deficiency dramatically inhibits Salmonella replication, which is linked to the metabolic state of macrophages and the level of intracellular glucose available to bacteria. Glucose 152-159 peroxisome proliferator activator receptor delta Mus musculus 0-9 23954156-6 2013 Pharmacological activation of PPARdelta increases glucose availability and enhances bacterial replication in macrophages and mice, while Salmonella fail to persist in Ppardelta null mice. Glucose 50-57 peroxisome proliferator activator receptor delta Mus musculus 30-39 23811944-1 2013 The peroxisome proliferator-activated receptor-delta (PPARdelta) regulates a multitude of physiological processes associated with glucose and lipid metabolism, inflammation, and proliferation. Glucose 130-137 peroxisome proliferator activator receptor delta Mus musculus 4-52 23811944-1 2013 The peroxisome proliferator-activated receptor-delta (PPARdelta) regulates a multitude of physiological processes associated with glucose and lipid metabolism, inflammation, and proliferation. Glucose 130-137 peroxisome proliferator activator receptor delta Mus musculus 54-63 22135324-3 2011 Transcriptional profiling revealed that the lactate dehydrogenase b (Ldhb)/Ldha gene expression ratio is increased in MCK-PPARbeta/delta muscle, an isoenzyme shift that diverts pyruvate into the mitochondrion for the final steps of glucose oxidation. Glucose 232-239 peroxisome proliferator activator receptor delta Mus musculus 122-130 22933110-8 2012 PPARdelta agonist GW1516 restored EDRs in mouse aortae under high-glucose conditions or in db/db mouse aortae ex vivo. Glucose 66-73 peroxisome proliferator activator receptor delta Mus musculus 0-9 23093780-6 2012 Analyses of insulin release from isolated PPARbeta/delta-deficient islets revealed an accelerated second phase of glucose-stimulated insulin secretion. Glucose 114-121 peroxisome proliferator activator receptor delta Mus musculus 42-50 22135324-5 2011 MCK-PPARbeta/delta muscle was shown to have high glycogen stores, increased levels of GLUT4, and augmented capacity for mitochondrial pyruvate oxidation, suggesting a broad reprogramming of glucose utilization pathways. Glucose 190-197 peroxisome proliferator activator receptor delta Mus musculus 4-12 21272187-0 2011 A new, highly selective murine peroxisome proliferator-activated receptor delta agonist increases responsiveness to thermogenic stimuli and glucose uptake in skeletal muscle in obese mice. Glucose 140-147 peroxisome proliferator activator receptor delta Mus musculus 31-79 21617181-4 2011 RESULTS: First, we observed that the PPAR-beta/-delta agonist GW501516 prevented both IL-6-dependent reduction in insulin-stimulated Akt phosphorylation and glucose uptake in adipocytes. Glucose 157-164 peroxisome proliferator activator receptor delta Mus musculus 37-46 21272187-13 2011 CONCLUSIONS: PPARdelta agonism reduced food intake and independently elicited metabolic effects that included increased responsiveness to beta(3)-adrenoceptor stimulation, increased glucose utilization and fat oxidation in soleus muscle of Lep(ob)/Lep(ob) but not lean mice and increased glucose utilization in vivo in Lep(ob)/Lep(ob) mice. Glucose 182-189 peroxisome proliferator activator receptor delta Mus musculus 13-22 21272187-13 2011 CONCLUSIONS: PPARdelta agonism reduced food intake and independently elicited metabolic effects that included increased responsiveness to beta(3)-adrenoceptor stimulation, increased glucose utilization and fat oxidation in soleus muscle of Lep(ob)/Lep(ob) but not lean mice and increased glucose utilization in vivo in Lep(ob)/Lep(ob) mice. Glucose 288-295 peroxisome proliferator activator receptor delta Mus musculus 13-22 20009009-6 2010 Pathways downregulated by PPARbeta/delta deletion included lipoprotein metabolism and various pathways related to glucose utilization, which correlated with elevated plasma glucose and triglycerides and reduced plasma cholesterol in PPARbeta/delta-/- mice. Glucose 114-121 peroxisome proliferator activator receptor delta Mus musculus 26-34 21059653-3 2011 We demonstrate here that adenovirus-mediated liver-restricted PPARdelta activation reduces fasting glucose levels in chow- and high fat-fed mice. Glucose 99-106 peroxisome proliferator activator receptor delta Mus musculus 62-71 21059653-8 2011 The altered substrate utilization by PPARdelta also results in a secondary effect on AMP-activated protein kinase activation, which likely contributes to the glucose-lowering activity. Glucose 158-165 peroxisome proliferator activator receptor delta Mus musculus 37-46 21059653-9 2011 Collectively, our data suggest that PPARdelta controls hepatic energy substrate homeostasis by coordinated regulation of glucose and fatty acid metabolism, which provide a molecular basis for developing PPARdelta agonists to manage hyperglycemia and insulin resistance. Glucose 121-128 peroxisome proliferator activator receptor delta Mus musculus 36-45 21059653-9 2011 Collectively, our data suggest that PPARdelta controls hepatic energy substrate homeostasis by coordinated regulation of glucose and fatty acid metabolism, which provide a molecular basis for developing PPARdelta agonists to manage hyperglycemia and insulin resistance. Glucose 121-128 peroxisome proliferator activator receptor delta Mus musculus 203-212 20009009-6 2010 Pathways downregulated by PPARbeta/delta deletion included lipoprotein metabolism and various pathways related to glucose utilization, which correlated with elevated plasma glucose and triglycerides and reduced plasma cholesterol in PPARbeta/delta-/- mice. Glucose 114-121 peroxisome proliferator activator receptor delta Mus musculus 233-241 20009009-6 2010 Pathways downregulated by PPARbeta/delta deletion included lipoprotein metabolism and various pathways related to glucose utilization, which correlated with elevated plasma glucose and triglycerides and reduced plasma cholesterol in PPARbeta/delta-/- mice. Glucose 173-180 peroxisome proliferator activator receptor delta Mus musculus 26-34 20009009-9 2010 Our data indicate that PPARbeta/delta governs glucose utilization and lipoprotein metabolism and has an important anti-inflammatory role in liver. Glucose 46-53 peroxisome proliferator activator receptor delta Mus musculus 23-31 21318167-1 2010 Peroxisome proliferator-activated receptordelta (PPARdelta) regulates a multiplicity of physiological processes associated with glucose and lipid metabolism, inflammation, and proliferation. Glucose 128-135 peroxisome proliferator activator receptor delta Mus musculus 0-47 19818749-3 2010 Whether PPARdelta is involved in the regulation of glucose metabolism is not completely understood. Glucose 51-58 peroxisome proliferator activator receptor delta Mus musculus 8-17 19818749-7 2010 Following intravenous glucose (1g/kg), glucose tolerance was improved after PPARdelta activation (K(G) 1.3+/-0.6 vs. -0.05+/-0.7 %/min, P=0.048). Glucose 22-29 peroxisome proliferator activator receptor delta Mus musculus 76-85 19818749-11 2010 This suggests that activation of PPARdelta improves glucose metabolism and may therefore potentially be target for treatment of type 2 diabetes. Glucose 52-59 peroxisome proliferator activator receptor delta Mus musculus 33-42 21318167-1 2010 Peroxisome proliferator-activated receptordelta (PPARdelta) regulates a multiplicity of physiological processes associated with glucose and lipid metabolism, inflammation, and proliferation. Glucose 128-135 peroxisome proliferator activator receptor delta Mus musculus 49-58 18037994-7 2007 In reporter assays, we showed that PPARbeta/delta and PPARalpha exerted differential transcriptional control of the GLUT4 promoter, which may explain the observed isotype-specific effects on glucose uptake. Glucose 191-198 peroxisome proliferator activator receptor delta Mus musculus 35-43 18096720-7 2008 Subsequently, high glucose-induced PGE(2) stimulated PPARdelta expression directly or through Akt phosphorylation indirectly through the E type prostaglandin receptor receptors. Glucose 19-26 peroxisome proliferator activator receptor delta Mus musculus 53-62 18096720-8 2008 The PPARdelta antagonist inhibited the 25 mM glucose-induced DNA synthesis. Glucose 45-52 peroxisome proliferator activator receptor delta Mus musculus 4-13 18096720-9 2008 Moreover, transfection with a pool of PPARdelta-specific small interfering RNA inhibited the 25 mM glucose-induced DNA synthesis and G1/S phase progression. Glucose 99-106 peroxisome proliferator activator receptor delta Mus musculus 38-47 18096720-10 2008 Twenty-five millimolar glucose also increased the level of the cell cycle regulatory proteins (cyclin E/cyclin-dependent kinase [CDK] 2 and cyclin D1/CDK 4) and decreased p21(WAF1/Cip1) and p27(Kip1), which were blocked by the inhibition of the cPLA(2), COX-2, or PPARdelta pathways. Glucose 23-30 peroxisome proliferator activator receptor delta Mus musculus 264-273 18096720-11 2008 In conclusion, high glucose promotes mouse ESC growth in part through the cPLA(2)-mediated PGE(2) synthesis and in part through PPARdelta pathways. Glucose 20-27 peroxisome proliferator activator receptor delta Mus musculus 128-137 19968882-9 2009 CONCLUSIONS: Although activation of both PPARdelta and PPARgamma lead to increased insulin sensitivity and glucose tolerance, PPARdelta activation was functionally distinct from PPARgamma activation, and was characterized by increased hepatic and peripheral fatty acid oxidative metabolism, demonstrating the distinctive catabolic role of this receptor compared with PPARgamma. Glucose 107-114 peroxisome proliferator activator receptor delta Mus musculus 41-50 35163565-7 2022 As the PPARD mice aged from 10 weeks to 35 weeks and 55 weeks, we observed significant changes in levels of the metabolites inosine monophosphate (p = 0.0054), adenosine monophosphate (p = 0.009), UDP-glucose (p = 0.0006), and oxypurinol (p = 0.039). Glucose 201-208 peroxisome proliferator activator receptor delta Mus musculus 7-12 16492734-0 2006 PPARdelta regulates glucose metabolism and insulin sensitivity. Glucose 20-27 peroxisome proliferator activator receptor delta Mus musculus 0-9 16492734-4 2006 Euglycemic-hyperinsulinemic-clamp experiments further demonstrate that a PPARdelta-specific agonist suppresses hepatic glucose output, increases glucose disposal, and inhibits free fatty acid release from adipocytes. Glucose 119-126 peroxisome proliferator activator receptor delta Mus musculus 73-82 16492734-5 2006 Unexpectedly, gene array and functional analyses suggest that PPARdelta ameliorates hyperglycemia by increasing glucose flux through the pentose phosphate pathway and enhancing fatty acid synthesis. Glucose 112-119 peroxisome proliferator activator receptor delta Mus musculus 62-71 15793256-2 2005 Recently, a specific PPARdelta activator (GW501516) was reported to attenuate plasma glucose and insulin levels when administered to genetically obese ob/ob mice. Glucose 85-92 peroxisome proliferator activator receptor delta Mus musculus 21-30 34380027-1 2021 Peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) activates AMP-activated protein kinase (AMPK) and plays a crucial role in glucose and lipid metabolism. Glucose 145-152 peroxisome proliferator activator receptor delta Mus musculus 0-69 32001235-12 2020 These data indicate that omentin-1 protects against high glucose-induced vascular-endothelial dysfunction through inhibiting ER stress and oxidative stress and increasing NO production via activation of AMPK/PPARdelta pathway. Glucose 57-64 peroxisome proliferator activator receptor delta Mus musculus 208-217 32001235-0 2020 Omentin-1 protects against high glucose-induced endothelial dysfunction via the AMPK/PPARdelta signaling pathway. Glucose 32-39 peroxisome proliferator activator receptor delta Mus musculus 85-94